| Basic Information | |
|---|---|
| Species | Malus domestica |
| Cazyme ID | MDP0000238047 |
| Family | GT57 |
| Protein Properties | Length: 735 Molecular Weight: 84342.6 Isoelectric Point: 8.7405 |
| Chromosome | Chromosome/Scaffold: 005927395 Start: 8804 End: 17685 |
| Description | ALG6, ALG8 glycosyltransferase family |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GT57 | 221 | 555 | 0 |
| DETSIWTLDYPPFFAYFERLLSVFAXLIDPQIVHLQKGLNYSSNTVLYFQRISVILSDLCLLYGVFRLTRNSDSMKQKMIWVLVIWSPMLVIVDHLHFQY NGFLLGILLISLSCLEEGRDLMGGLIFAVLLCFKHLFAVAAPVYFVYLLRHYCWKGLVRGFWRLSVLGTVVVAVFALAYAPFVYHGQMQQVIHRMFPFGR GLCHAYWAPNFWVFYIILDKVLAFLLGRLGFNIQAPAASFTGGLVGDSSPFAVLPQVTPATTFILVLISLSPCLIKAWRHPRPSLITRWVAYAYTCGFMF GWHVHEKASLHFVIPLAIVAVQSLDNARHYFLISI | |||
| Full Sequence |
|---|
| Protein Sequence Length: 735 Download |
| YYSHNNDYLE ICRCYKAIYD IPSVKENSAQ WIPVLRKICW YLVLAPYDPM QSSLLNSILE 60 DKNLSELPYF RLLLKQVVTM EVIQWNTLWN TYKDEFESEK NMLGGSLGDK AAEDLRQRII 120 EHNILVVSKN YSRITLKRLA ELLCLSIQEA EKHLSDMVVS KALVAKIDRP VGIXCFQTAK 180 DSNNVLNSWA MNLEKLLDLV EKSCHQIHKE TMVHKASLKS DETSIWTLDY PPFFAYFERL 240 LSVFAXLIDP QIVHLQKGLN YSSNTVLYFQ RISVILSDLC LLYGVFRLTR NSDSMKQKMI 300 WVLVIWSPML VIVDHLHFQY NGFLLGILLI SLSCLEEGRD LMGGLIFAVL LCFKHLFAVA 360 APVYFVYLLR HYCWKGLVRG FWRLSVLGTV VVAVFALAYA PFVYHGQMQQ VIHRMFPFGR 420 GLCHAYWAPN FWVFYIILDK VLAFLLGRLG FNIQAPAASF TGGLVGDSSP FAVLPQVTPA 480 TTFILVLISL SPCLIKAWRH PRPSLITRWV AYAYTCGFMF GWHVHEKASL HFVIPLAIVA 540 VQSLDNARHY FLISIEKRGG VSFKDLFEWG LICFRIANYR QMLXSHKLAL PTELYPRPGV 600 KLSCYSLFPL LYEAQEYPIR VLLLLLHSTL MWLGFSAQFA NGIALETANS GKKKDDDFQT 660 KRRSVAAAQK GGFVIGCVHW SYLVGMLLVE IWGQFLHPII FGEKLPFIPL MLISTYCGIG 720 VMYSFIWQLK WILDS |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| smart00753 | PAM | 3.0e-11 | 113 | 196 | 85 | + PCI/PINT associated module. | ||
| smart00088 | PINT | 3.0e-11 | 113 | 196 | 85 | + motif in proteasome subunits, Int-6, Nip-1 and TRIP-15. Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function. | ||
| pfam01399 | PCI | 1.0e-16 | 70 | 176 | 107 | + PCI domain. This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15). | ||
| COG5071 | RPN5 | 3.0e-45 | 4 | 214 | 211 | + 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones] | ||
| pfam03155 | Alg6_Alg8 | 3.0e-81 | 221 | 727 | 514 | + ALG6, ALG8 glycosyltransferase family. N-linked (asparagine-linked) glycosylation of proteins is mediated by a highly conserved pathway in eukaryotes, in which a lipid (dolichol phosphate)-linked oligosaccharide is assembled at the endoplasmic reticulum membrane prior to the transfer of the oligosaccharide moiety to the target asparagine residues. This oligosaccharide is composed of Glc(3)Man(9)GlcNAc(2). The addition of the three glucose residues is the final series of steps in the synthesis of the oligosaccharide precursor. Alg6 transfers the first glucose residue, and Alg8 transfers the second one. In the human alg6 gene, a C->T transition, which causes Ala333 to be replaced with Val, has been identified as the cause of a congenital disorder of glycosylation, designated as type Ic OMIM:603147. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0005515 | protein binding |
| GO:0005789 | endoplasmic reticulum membrane |
| GO:0016758 | transferase activity, transferring hexosyl groups |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | EAY87118.1 | 0 | 220 | 733 | 56 | 516 | hypothetical protein OsI_08520 [Oryza sativa Indica Group] |
| RefSeq | NP_181994.5 | 0 | 221 | 733 | 56 | 505 | transferase, transferring glycosyl groups / transferase, transferring hexosyl groups [Arabidopsis thaliana] |
| Swiss-Prot | O80505 | 0 | 221 | 555 | 56 | 390 | ALG8_ARATH RecName: Full=Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase; AltName: Full=Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase; AltName: Full=Asparagine-linked glycosylation protein 8 homolog |
| RefSeq | XP_002269114.1 | 0 | 206 | 735 | 43 | 531 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002521523.1 | 0 | 221 | 735 | 62 | 492 | dolichyl glycosyltransferase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 4bgr_P | 2e-34 | 4 | 214 | 230 | 440 | A Chain A, Crystal Structure Of The C-Terminal Globular Domain Of Oligosaccharyltransferase (Af_0329) From Archaeoglobus Fulgidus |
| PDB | 4b4t_P | 2e-34 | 4 | 214 | 230 | 440 | S Chain S, Near-Atomic Resolution Structural Model Of The Yeast 26s Proteasome |
| PDB | 1ufm_A | 0.00008 | 115 | 182 | 12 | 79 | A Chain A, Solution Structure Of The Pci Domain |
