| Basic Information | |
|---|---|
| Species | Malus domestica |
| Cazyme ID | MDP0000242071 |
| Family | GH79 |
| Protein Properties | Length: 546 Molecular Weight: 60836.8 Isoelectric Point: 8.4386 |
| Chromosome | Chromosome/Scaffold: 013407145 Start: 13499 End: 16015 |
| Description | glucuronidase 2 |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH79 | 45 | 539 | 0 |
| DNNFVCATIDWWNNEKCNYGHCPWGHSSALNLNLSHPLLAKSIQAFDQLRIRIGGSLEDQLLYDVGNLKYPCHPFRKLENGLFGFSRGCLNMSRWDELNQ FFSKTKSIVTFSLNALLGRHHKGGGVWVGEWDSSNAYDFINYTVSKRYEIDSWEFGNELSGRGVGASVGAGQYGRDLIKLKHIINHLYNESVAKPALMAP GGFFDQSWFARLLQVSGSGTVDIISQHIYNLGAGVDPKLVKKILNPYYLNRAYGLFHDLELTVKXNGPWASIWVGESGGAYNSGGRNVSDTFVNSFWYLD QLGMSAKHNTRVYCRQSLVGGNYGLLNKTSFVPNPDYYSALLWHRLMGQGVLSAHNNGSADLRTYAHCTRGRAGITLLLINLSNETNFXTNVENILDADL GAHARNISKESYFKRGLKRTVSWVGRKALDEAICREEYHLTPKDGDLRSKTMVLNGAPLEITKDGNIPELEPARVDMKAPLTIAPLSIKFVVLPY | |||
| Full Sequence |
|---|
| Protein Sequence Length: 546 Download |
| MEFRLSLVLF LVSLPAILAQ DFGKADNVEN VKVVVNGILS VARVDNNFVC ATIDWWNNEK 60 CNYGHCPWGH SSALNLNLSH PLLAKSIQAF DQLRIRIGGS LEDQLLYDVG NLKYPCHPFR 120 KLENGLFGFS RGCLNMSRWD ELNQFFSKTK SIVTFSLNAL LGRHHKGGGV WVGEWDSSNA 180 YDFINYTVSK RYEIDSWEFG NELSGRGVGA SVGAGQYGRD LIKLKHIINH LYNESVAKPA 240 LMAPGGFFDQ SWFARLLQVS GSGTVDIISQ HIYNLGAGVD PKLVKKILNP YYLNRAYGLF 300 HDLELTVKXN GPWASIWVGE SGGAYNSGGR NVSDTFVNSF WYLDQLGMSA KHNTRVYCRQ 360 SLVGGNYGLL NKTSFVPNPD YYSALLWHRL MGQGVLSAHN NGSADLRTYA HCTRGRAGIT 420 LLLINLSNET NFXTNVENIL DADLGAHARN ISKESYFKRG LKRTVSWVGR KALDEAICRE 480 EYHLTPKDGD LRSKTMVLNG APLEITKDGN IPELEPARVD MKAPLTIAPL SIKFVVLPYF 540 DAQACL |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 1.0e-168 | 29 | 347 | 319 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI15157.1 | 0 | 12 | 545 | 12 | 512 | unnamed protein product [Vitis vinifera] |
| RefSeq | NP_196400.2 | 0 | 1 | 545 | 1 | 542 | AtGUS2 (Arabidopsis thaliana glucuronidase 2); beta-glucuronidase |
| RefSeq | XP_002284470.1 | 0 | 12 | 545 | 12 | 538 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002321464.1 | 0 | 1 | 545 | 1 | 540 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002514696.1 | 0 | 15 | 545 | 15 | 538 | Heparanase-2, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.0003 | 265 | 426 | 235 | 400 | A Chain A, Structure And Mechanisim Of Core 2 Beta1,6-N- Acetylglucosaminyltransferase: A Metal-Ion Independent Gt-A Glycosyltransferase |
| PDB | 3vnz_A | 0.0003 | 265 | 426 | 235 | 400 | A Chain A, Structure And Mechanisim Of Core 2 Beta1,6-N- Acetylglucosaminyltransferase: A Metal-Ion Independent Gt-A Glycosyltransferase |
| PDB | 3vny_A | 0.0003 | 265 | 426 | 235 | 400 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
