| Basic Information | |
|---|---|
| Species | Malus domestica |
| Cazyme ID | MDP0000251576 |
| Family | GT47 |
| Protein Properties | Length: 425 Molecular Weight: 48307.2 Isoelectric Point: 10.2521 |
| Chromosome | Chromosome/Scaffold: 015468367 Start: 6258 End: 10116 |
| Description | Exostosin family protein |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GT47 | 88 | 303 | 2.5e-29 |
| LKIYVYDAREIDGLKALMRGRDGVIDPKACLKGQWGTQVKIHRLLLNSRFRTRKKDEAXLFFVPTYTKCVRMMGGLNDKEINQTYVKVLSQMPXFRRSGG RDHIFVFPSGAGAHLFRSWATFINRSIILTPEVFPYSSLSFMLKGDRTDKKDTSAFNTWKDIIIPGNVEDGMTTNGPTLVHPLPISKRKYLANYLGRAQG KAGRLKLIELSKKFPD | |||
| Full Sequence |
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| Protein Sequence Length: 425 Download |
| MGSVSNKPRP FSAQHHQQPL CTRTHQIGAL LLVAATFFFT SLLDRSFRPC ASHFPAVDLL 60 PNSRSSVQVX GGRDLLWPQR GYGPQLDLKI YVYDAREIDG LKALMRGRDG VIDPKACLKG 120 QWGTQVKIHR LLLNSRFRTR KKDEAXLFFV PTYTKCVRMM GGLNDKEINQ TYVKVLSQMP 180 XFRRSGGRDH IFVFPSGAGA HLFRSWATFI NRSIILTPEV FPYSSLSFML KGDRTDKKDT 240 SAFNTWKDII IPGNVEDGMT TNGPTLVHPL PISKRKYLAN YLGRAQGKAG RLKLIELSKK 300 FPDKECVPVL LSDQVELPFQ NVVDYTQISI KWPSTLIGPE LLQYLESIPD KNIEGMISRG 360 RQVRCLWAYA SESASCSAMH GILWELQRKV RLFHQSTETF WLHNGSVVNR NLVEFSDWRP 420 PMPLP |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03016 | Exostosin | 8.0e-25 | 88 | 348 | 316 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | AAF87908.1 | 0 | 4 | 425 | 5 | 414 | AC015447_18 Hypothetical protein [Arabidopsis thaliana] |
| RefSeq | NP_564141.1 | 0 | 4 | 425 | 5 | 462 | exostosin family protein [Arabidopsis thaliana] |
| RefSeq | XP_002265632.1 | 0 | 1 | 425 | 1 | 459 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002300942.1 | 0 | 1 | 425 | 1 | 460 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002307477.1 | 0 | 1 | 425 | 1 | 460 | predicted protein [Populus trichocarpa] |
| Hydropathy |
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| EST Download unfiltered results here | ||||
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| Hit | Length | Start | End | EValue |
| DT562513 | 299 | 4 | 302 | 0 |
| CN887757 | 205 | 13 | 217 | 0 |
| BX841155 | 303 | 4 | 306 | 0 |
| DY290282 | 300 | 1 | 298 | 0 |
| DY295548 | 305 | 1 | 303 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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| Phylogeny |
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