| Basic Information | |
|---|---|
| Species | Malus domestica |
| Cazyme ID | MDP0000256891 |
| Family | GT47 |
| Protein Properties | Length: 343 Molecular Weight: 39344.6 Isoelectric Point: 9.3357 |
| Chromosome | Chromosome/Scaffold: 007239507 Start: 67 End: 1455 |
| Description | Exostosin family protein |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GT47 | 4 | 294 | 0 |
| SFKIYVYPTNSNNSDPPSSPSFASFPAVFLPHPNPFDPKLGNYFSEHMFKLSLLSSSFVTNDPQNAHLFFLPFSVNVLRNDPRVHSESSIAEFVAHYTAA VGRDFKFWNASSGADHFYACCHSVCREAAAQHAGLRNNAIQLTCSSSYFQRLYVTHKDVALPQVWPRPPQQSLNPPQSRDKLVYFSGRIQNSDIRQQLID LWGNDTRMDIFPGNPSYPYEEGFRRSKFCLHVRGYEVNTARVSDAIHYGCIPVIISNHYELPFANVLDWTKFSVIVNSGEVSLLKKTLLSI | |||
| Full Sequence |
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| Protein Sequence Length: 343 Download |
| MLQSFKIYVY PTNSNNSDPP SSPSFASFPA VFLPHPNPFD PKLGNYFSEH MFKLSLLSSS 60 FVTNDPQNAH LFFLPFSVNV LRNDPRVHSE SSIAEFVAHY TAAVGRDFKF WNASSGADHF 120 YACCHSVCRE AAAQHAGLRN NAIQLTCSSS YFQRLYVTHK DVALPQVWPR PPQQSLNPPQ 180 SRDKLVYFSG RIQNSDIRQQ LIDLWGNDTR MDIFPGNPSY PYEEGFRRSK FCLHVRGYEV 240 NTARVSDAIH YGCIPVIISN HYELPFANVL DWTKFSVIVN SGEVSLLKKT LLSITRQSYA 300 TLYRNLIKVR RHFVWHETPK GYDSFHMTAY QLWLKRSSLR LSA |
| Functional Domains Download unfiltered results here | ||||||
|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description |
| pfam03016 | Exostosin | 7.0e-50 | 46 | 294 | 264 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI29307.1 | 0 | 1 | 342 | 113 | 448 | unnamed protein product [Vitis vinifera] |
| RefSeq | XP_002265438.1 | 0 | 1 | 341 | 118 | 443 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002297901.1 | 0 | 1 | 342 | 110 | 456 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002512716.1 | 0 | 1 | 342 | 91 | 425 | catalytic, putative [Ricinus communis] |
| RefSeq | XP_002525728.1 | 0 | 1 | 341 | 1 | 326 | catalytic, putative [Ricinus communis] |
| Hydropathy |
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| EST Download unfiltered results here | ||||
|---|---|---|---|---|
| Hit | Length | Start | End | EValue |
| EE663632 | 234 | 110 | 343 | 0 |
| EG631205 | 234 | 110 | 343 | 0 |
| DT579774 | 268 | 76 | 343 | 0 |
| BU895949 | 238 | 95 | 332 | 0 |
| EX686502 | 220 | 90 | 309 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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