Basic Information | |
---|---|
Species | Malus domestica |
Cazyme ID | MDP0000257243 |
Family | AA3 |
Protein Properties | Length: 616 Molecular Weight: 68217.3 Isoelectric Point: 9.2612 |
Chromosome | Chromosome/Scaffold: 005640206 Start: 3034 End: 5881 |
Description | Glucose-methanol-choline (GMC) oxidoreductase family protein |
View CDS |
External Links |
---|
NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
---|---|---|---|
Family | Start | End | Evalue |
AA3 | 128 | 609 | 0 |
PLQEEYDYIVVGGGTAGCPLATTLSANYSVLLLERGNIPSAYPNVLHDGKTPAQRFTSEDGVANLRGRILGGSSMINIGXYSRADGEFYQKSGIKLDMNL VNNSYXWVENTVAFRPNVTHWQSVVKDAMLEAGVRPDNGLTLDHILGSKVSATLFDDRGKRHGAVEHLNKAHPKNLRVAILATVERIIFSSKASGLSAKG IIYSDSNGRSHRALIRGKGEVILSAXAIGSXQLLLLSGVGPKSYLSSRKIPVVHPQPYVGQFMRDNPRNYITILPPFQVEASTVQVVGITSDYYIETFSG LPFSRQAFSLFPSPTIPMTINSSFGHIMVKFPGPLSYGSLELQSSYDVKVAPNVKFNYFAQEADLSHCVSAVRKIGDLLKTNSLKPYKAQDLPGVEGFNL FGPPLPVNQSDDASFETFCRDTVATFWHYHGGCLVGKVVDEDLRVMGIKALRVVDGSVFNVLSPGTNPQATLMMLGRYFGVQ |
Full Sequence |
---|
Protein Sequence Length: 616 Download |
MPANFMDQIK VEPDKCIALR ILVPTAHLYK KESESSYIKI HPLCLRSYWK QLQNQRKYFG 60 LRIERRNMEK STTAAILLLL YFFGFCPQPG VPSFANPSDD LGKYSMKVSL VFQNFSYVKF 120 VRNATDLPLQ EEYDYIVVGG GTAGCPLATT LSANYSVLLL ERGNIPSAYP NVLHDGKTPA 180 QRFTSEDGVA NLRGRILGGS SMINIGXYSR ADGEFYQKSG IKLDMNLVNN SYXWVENTVA 240 FRPNVTHWQS VVKDAMLEAG VRPDNGLTLD HILGSKVSAT LFDDRGKRHG AVEHLNKAHP 300 KNLRVAILAT VERIIFSSKA SGLSAKGIIY SDSNGRSHRA LIRGKGEVIL SAXAIGSXQL 360 LLLSGVGPKS YLSSRKIPVV HPQPYVGQFM RDNPRNYITI LPPFQVEAST VQVVGITSDY 420 YIETFSGLPF SRQAFSLFPS PTIPMTINSS FGHIMVKFPG PLSYGSLELQ SSYDVKVAPN 480 VKFNYFAQEA DLSHCVSAVR KIGDLLKTNS LKPYKAQDLP GVEGFNLFGP PLPVNQSDDA 540 SFETFCRDTV ATFWHYHGGC LVGKVVDEDL RVMGIKALRV VDGSVFNVLS PGTNPQATLM 600 MLGRYFGVQM LEERSE |
Functional Domains Download unfiltered results here | ||||||||
---|---|---|---|---|---|---|---|---|
Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
TIGR01810 | betA | 3.0e-21 | 134 | 603 | 548 | + choline dehydrogenase. Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli , Staphylococcus xylosus , and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified [Cellular processes, Adaptations to atypical conditions]. | ||
TIGR03970 | Rv0697 | 3.0e-23 | 134 | 603 | 524 | + dehydrogenase, Rv0697 family. This model describes a set of dehydrogenases belonging to the glucose-methanol-choline oxidoreductase (GMC oxidoreductase) family. Members of the present family are restricted to Actinobacterial genome contexts containing also members of families TIGR03962 and TIGR03969 (the mycofactocin system), and are proposed to be uniform in function. | ||
pfam05199 | GMC_oxred_C | 5.0e-25 | 461 | 603 | 148 | + GMC oxidoreductase. This domain found associated with pfam00732. | ||
COG2303 | BetA | 2.0e-33 | 131 | 614 | 559 | + Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism] | ||
PLN02785 | PLN02785 | 1.0e-145 | 131 | 614 | 537 | + Protein HOTHEAD |
Gene Ontology | |
---|---|
GO Term | Description |
GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors |
GO:0050660 | flavin adenine dinucleotide binding |
GO:0055114 | oxidation-reduction process |
Annotations - NR Download unfiltered results here | |||||||
---|---|---|---|---|---|---|---|
Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | AAL11514.1 | 0 | 68 | 615 | 1 | 545 | AF412329_1 R-oxynitrile lyase isoenzyme 1 precursor [Prunus dulcis] |
GenBank | ACY69987.1 | 0 | 88 | 615 | 16 | 537 | mandelonitrile lyase 1 [Eriobotrya japonica] |
GenBank | ACY69988.1 | 0 | 88 | 605 | 16 | 527 | mandelonitrile lyase 2 [Eriobotrya japonica] |
Swiss-Prot | O50048 | 0 | 68 | 614 | 1 | 546 | MDL2_PRUSE RecName: Full=(R)-mandelonitrile lyase 2; AltName: Full=Hydroxynitrile lyase 2; Short=(R)-oxynitrilase 2; Flags: Precursor |
Swiss-Prot | P52707 | 0 | 68 | 615 | 1 | 546 | MDL3_PRUSE RecName: Full=(R)-mandelonitrile lyase 3; AltName: Full=Hydroxynitrile lyase 3; Short=(R)-oxynitrilase 3; Flags: Precursor |
Annotations - PDB Download unfiltered results here | |||||||
---|---|---|---|---|---|---|---|
Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3red_L | 0 | 113 | 615 | 7 | 519 | A Chain A, 3.0 A Structure Of The Prunus Mume Hydroxynitrile Lyase Isozyme-1 |
PDB | 3red_K | 0 | 113 | 615 | 7 | 519 | A Chain A, 3.0 A Structure Of The Prunus Mume Hydroxynitrile Lyase Isozyme-1 |
PDB | 3red_J | 0 | 113 | 615 | 7 | 519 | A Chain A, 3.0 A Structure Of The Prunus Mume Hydroxynitrile Lyase Isozyme-1 |
PDB | 3red_I | 0 | 113 | 615 | 7 | 519 | A Chain A, 3.0 A Structure Of The Prunus Mume Hydroxynitrile Lyase Isozyme-1 |
PDB | 3red_H | 0 | 113 | 615 | 7 | 519 | A Chain A, 3.0 A Structure Of The Prunus Mume Hydroxynitrile Lyase Isozyme-1 |
EST Download unfiltered results here | ||||
---|---|---|---|---|
Hit | Length | Start | End | EValue |
HO796743 | 533 | 134 | 614 | 0 |
CN493721 | 189 | 366 | 554 | 0 |
DW341064 | 204 | 402 | 605 | 0 |
DT001380 | 231 | 65 | 283 | 0 |
EX518322 | 310 | 253 | 559 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
---|