Basic Information | |
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Species | Malus domestica |
Cazyme ID | MDP0000264823 |
Family | GT2 |
Protein Properties | Length: 1145 Molecular Weight: 131274 Isoelectric Point: 8.5368 |
Chromosome | Chromosome/Scaffold: 00105596 Start: 3699 End: 13217 |
Description | Cellulose-synthase-like C6 |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT2 | 235 | 409 | 5.5e-29 |
IPMCNEREVYHQSIAAVCIQDWPKERMLVQVLDDSDDREVQQLIKAEVNKWQQRGVPILYRHRLIRTGYKAGNLKSAMSCDYVKNYEFVAIFDSDFQPEP EFLKKTVPYFKGNDDLGLVQTRWSFVNKDENLLTRLQNINLSFHFEVEQQVNGVFINFFGFNGTAGVWRIKALEE |
Full Sequence |
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Protein Sequence Length: 1145 Download |
MSRAQNHEFQ EWWNKQRKSN HDLLLSSDES SHLLTVDVHS PGPDRTVGKD RSRSARQLSW 60 VCLLKFQQIA ASLTSLGNSF LVLLRTANRR VTSPDSPADS ASSRLYRAIK VFLIVVLLLL 120 CFELVAYFKG WHFSPPSVRS GELAELVYAN WLHVRVNYLA PLLQSFTNVC IVLFLIQSVD 180 RVVLVLGCFW IKFRRVKPKA VMEYKTTSSS SSNNVEEGNA ENVNLEDYPM VLLQIPMCNE 240 REVYHQSIAA VCIQDWPKER MLVQVLDDSD DREVQQLIKA EVNKWQQRGV PILYRHRLIR 300 TGYKAGNLKS AMSCDYVKNY EFVAIFDSDF QPEPEFLKKT VPYFKGNDDL GLVQTRWSFV 360 NKDENLLTRL QNINLSFHFE VEQQVNGVFI NFFGFNGTAG VWRIKALEEC GGWLERTTVE 420 DMDVAVRAHL CGWKFIYLND VKCLCELPES YGAYKKQQHR WHSGPMQLFR MCFFDILRSK 480 VSVTKKANLI FLFFLLRKLI LPFYSFTLFC IILPLTMFLP EAQLPAWVVC YVPGIMSVLN 540 ILPAPRSFPF IVPYLLFENT MSVTKFNAMI SGLFQFGSSY EWIVTKKLGR SSETDLIAFE 600 RESEPLVPTT SLHRSASESG LEELTKLETT KKTGKKRRNR LYRKEXVIAF VLLTASARSL 660 LSAQGIHFYF LLFQGITFLV VGLDLIGEQK AFAIRYVKSI FDIVKWMSNT NRLRPDAMYH 720 DENVSTEGYI SKRVPNKDEV SVFVGNGARL AVKFIGIVWL ELFFGFLLDL VDVAYIPSMR 780 RNLVLVSRLV KSKFKFDINK IGFSIFRSSN LIGDGVLTGD MFKLNYNIPM SEENLDWNEE 840 TTTMQEENLS DAMTDEVAIP IPVQNDQVTE PTQAVQQEEI IVVEHVQSNN APTLSKENLE 900 PVRMETRRST RTRKPAISND FLVYLQEAEF SSQEEDPLNF KKAIESLNNA YWQEAMQSEL 960 DSMNKNKRTK EYQLVYKRDS KLELVGYSDS DFAGYLDSFK STSGYIFTLA NGAVSWKSMK 1020 QDTVATSIMQ AEFVACYEAT SQAIWLRNFI NSLEIMNSIA KPVQIWCDNK VAVFYSTNNK 1080 RSPGTKHLNT KYALTRKKVK SGEIKVDYIN THAMLANPFT KVLPNVVFHK HAVNMGVTAT 1140 LDLLN |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
cd06427 | CESA_like_2 | 9.0e-28 | 229 | 467 | 244 | + CESA_like_2 is a member of the cellulose synthase superfamily. The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, Glucan Biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of glucan. | ||
COG1215 | COG1215 | 6.0e-31 | 227 | 471 | 247 | + Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane] | ||
cd06421 | CESA_CelA_like | 7.0e-46 | 235 | 469 | 236 | + CESA_CelA_like are involved in the elongation of the glucan chain of cellulose. Family of proteins related to Agrobacterium tumefaciens CelA and Gluconacetobacter xylinus BscA. These proteins are involved in the elongation of the glucan chain of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues. They are putative catalytic subunit of cellulose synthase, which is a glycosyltransferase using UDP-glucose as the substrate. The catalytic subunit is an integral membrane protein with 6 transmembrane segments and it is postulated that the protein is anchored in the membrane at the N-terminal end. | ||
cd09272 | RNase_HI_RT_Ty1 | 3.0e-54 | 985 | 1128 | 144 | + Ty1/Copia family of RNase HI in long-term repeat retroelements. Ribonuclease H (RNase H) enzymes are divided into two major families, Type 1 and Type 2, based on amino acid sequence similarities and biochemical properties. RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner in the presence of divalent cations. RNase H is widely present in various organisms, including bacteria, archaea and eukaryotes. RNase HI has also been observed as adjunct domains to the reverse transcriptase gene in retroviruses, in long-term repeat (LTR)-bearing and non-LTR retrotransposons. RNase HI in LTR retrotransposons perform degradation of the original RNA template, generation of a polypurine tract (the primer for plus-strand DNA synthesis), and final removal of RNA primers from newly synthesized minus and plus strands. The catalytic residues for RNase H enzymatic activity, three aspartatic acids and one glutamatic acid residue (DEDD) are unvaried across all RNase H domains. Phylogenetic patterns of RNase HI of LTR retroelements is classified into five major families, Ty3/Gypsy, Ty1/Copia, Bel/Pao, DIRS1 and the vertebrate retroviruses. Ty1/Copia family is widely distributed among the genomes of plants, fungi and animals. RNase H inhibitors have been explored as an anti-HIV drug target because RNase H inactivation inhibits reverse transcription. | ||
cd06437 | CESA_CaSu_A2 | 1.0e-102 | 229 | 465 | 237 | + Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex. Cellulose synthase (CESA) catalyzes the polymerization reaction of cellulose using UDP-glucose as the substrate. Cellulose is an aggregate of unbranched polymers of beta-1,4-linked glucose residues, which is an abundant polysaccharide produced by plants and in varying degrees by several other organisms including algae, bacteria, fungi, and even some animals. Genomes from higher plants harbor multiple CESA genes. There are ten in Arabidopsis. At least three different CESA proteins are required to form a functional complex. In Arabidopsis, CESA1, 3 and 6 and CESA4, 7 and 8, are required for cellulose biosynthesis during primary and secondary cell wall formation. CESA2 is very closely related to CESA6 and is viewed as a prime substitute for CESA6. They functionally compensate each other. The cesa2 and cesa6 double mutant plants were significantly smaller, while the single mutant plants were almost normal. |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CAN82493.1 | 0 | 1 | 689 | 66 | 751 | hypothetical protein [Vitis vinifera] |
EMBL | CBI35705.1 | 0 | 1 | 606 | 1 | 603 | unnamed protein product [Vitis vinifera] |
RefSeq | NP_187389.1 | 0 | 1 | 689 | 1 | 680 | ATCSLC6 (CELLULOSE-SYNTHASE LIKE C6); cellulose synthase/ transferase, transferring glycosyl groups [Arabidopsis thaliana] |
RefSeq | XP_002303072.1 | 0 | 2 | 689 | 3 | 676 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002324379.1 | 0 | 9 | 689 | 7 | 690 | predicted protein [Populus trichocarpa] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 4hg6_A | 2e-25 | 159 | 538 | 52 | 458 | B Chain B, Structure Of A Cellulose Synthase - Cellulose Translocation Intermediate |