Basic Information | |
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Species | Malus domestica |
Cazyme ID | MDP0000266169 |
Family | GT47 |
Protein Properties | Length: 530 Molecular Weight: 60453.3 Isoelectric Point: 9.8575 |
Chromosome | Chromosome/Scaffold: 002235539 Start: 6062 End: 9616 |
Description | Exostosin family protein |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 116 | 434 | 0 |
LLRVFMYELPSEFHFGLLDWKGKENQTWPNVKNPSHIPAYPGGLNLQHSIEYWLTLDLLSSSLPTXVRPCTVVRVHNSSQADVIFVPFFASLSYNRHSKL RGKEKVSVDKKLQEELVQYLMGRDEWKRKGGKDHLIVAHHPNSMLDARKKLGSAMFVLADFGRYPAEIANIEKDIIAPYRHLVMTVHSSKSASFNERPIL LYFRGAIYRKDGGKVRQELYYLLKDEKDVYFTFGSVRGNGINKASQGMASSKFCLNLAGDTPSSNRLFDAIASHCVPVIISDEIELPFEDFLDYSQFCIF VHSADAIKKGYLLNLLRGI |
Full Sequence |
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Protein Sequence Length: 530 Download |
MSEKSRLPSK FLFYLITISL FLLISSSVFL LQYSNTSFTP SSVFKLILLN GTSVYFEPLL 60 KSRQKNLLFL PSEVPLVDAG ISTTISELGC ENSNSSKKLE SLGKKKTIAC DSTQALLRVF 120 MYELPSEFHF GLLDWKGKEN QTWPNVKNPS HIPAYPGGLN LQHSIEYWLT LDLLSSSLPT 180 XVRPCTVVRV HNSSQADVIF VPFFASLSYN RHSKLRGKEK VSVDKKLQEE LVQYLMGRDE 240 WKRKGGKDHL IVAHHPNSML DARKKLGSAM FVLADFGRYP AEIANIEKDI IAPYRHLVMT 300 VHSSKSASFN ERPILLYFRG AIYRKDGGKV RQELYYLLKD EKDVYFTFGS VRGNGINKAS 360 QGMASSKFCL NLAGDTPSSN RLFDAIASHC VPVIISDEIE LPFEDFLDYS QFCIFVHSAD 420 AIKKGYLLNL LRGIKQETWT KMWEKLKEVV HHFEYQYPSQ PGDAVDMIWQ AVAHKKTSXQ 480 FKFHRKKRYD RVLTSSSSLE NLRSGRLIKQ MVRSISQKER ILYISGEKLG |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 5.0e-52 | 117 | 434 | 327 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
RefSeq | NP_565089.1 | 0 | 1 | 491 | 4 | 451 | exostosin family protein [Arabidopsis thaliana] |
RefSeq | XP_002284930.1 | 0 | 1 | 491 | 1 | 447 | PREDICTED: hypothetical protein isoform 1 [Vitis vinifera] |
RefSeq | XP_002284932.1 | 0 | 87 | 491 | 4 | 408 | PREDICTED: hypothetical protein isoform 2 [Vitis vinifera] |
RefSeq | XP_002320639.1 | 0 | 117 | 491 | 3 | 374 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002514760.1 | 0 | 1 | 491 | 1 | 486 | catalytic, putative [Ricinus communis] |