Basic Information | |
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Species | Malus domestica |
Cazyme ID | MDP0000267875 |
Family | GT20 |
Protein Properties | Length: 950 Molecular Weight: 107311 Isoelectric Point: 6.6936 |
Chromosome | Chromosome/Scaffold: 001417341 Start: 11921 End: 19212 |
Description | trehalose-6-phosphate synthase |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT20 | 82 | 575 | 0 |
SRXRLLVVANRLPVSAIRRGEDSWSLEMSAGGLVTALLGIKEFEARWIGWAGVNVPDEIGQKALTRALAEKRCIPVFLDEEIVHQYYNGYCNNILWPLFH YLGLPQEDRLATTRSFQSQFAAYKKANQMFADVVNEHYEEGDVVWVHDYHLMFLPKCLKDYNSKIKVGWFLHTPFPSSEIHRTLPSRSELLRSVLAADLV GFHTYDYARHFVSACTRILGLEGTPEGVEDQGRLTRVAAFPIGIDSDRFIRALDVPQVQEHIKELKERFAGRKVMLGVDRLDMIKGIPQKILAFEKFLEE NPTWRDKVVLLQIAVPTRTDVPEYQKLTSQVHEIVGRINGRFGTLTAVPIHHLDRSLDFHALCALYAVTGTILHTLALLVISPCVRLVSFSICPDIALVT SLRDGMNLVSYEFVACQDAKRGVLILSEFAGAAQSLGAGAILVNPWNITEVANSIAQALNMPSEEREKRHKHNFLHVTTHTAQEWAETFVSELN |
Full Sequence |
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Protein Sequence Length: 950 Download |
MPGNKYNSNS DHIPPNRVER LLRERELRKN NRGLNLNEPF EPELQLREDE NSKAAYIEQF 60 LEGAAAARAL NEGCEKQEXR PSRXRLLVVA NRLPVSAIRR GEDSWSLEMS AGGLVTALLG 120 IKEFEARWIG WAGVNVPDEI GQKALTRALA EKRCIPVFLD EEIVHQYYNG YCNNILWPLF 180 HYLGLPQEDR LATTRSFQSQ FAAYKKANQM FADVVNEHYE EGDVVWVHDY HLMFLPKCLK 240 DYNSKIKVGW FLHTPFPSSE IHRTLPSRSE LLRSVLAADL VGFHTYDYAR HFVSACTRIL 300 GLEGTPEGVE DQGRLTRVAA FPIGIDSDRF IRALDVPQVQ EHIKELKERF AGRKVMLGVD 360 RLDMIKGIPQ KILAFEKFLE ENPTWRDKVV LLQIAVPTRT DVPEYQKLTS QVHEIVGRIN 420 GRFGTLTAVP IHHLDRSLDF HALCALYAVT GTILHTLALL VISPCVRLVS FSICPDIALV 480 TSLRDGMNLV SYEFVACQDA KRGVLILSEF AGAAQSLGAG AILVNPWNIT EVANSIAQAL 540 NMPSEEREKR HKHNFLHVTT HTAQEWAETF VSELNDTVVE AQLRTRQVPP PLPNKDAIQS 600 YLQANNRLII LGFNVTLTEP VDTXERRGDQ IKEMELKLHP ELKETLSALA NDPTTTIVVI 660 SGSDRYVLDD NFGELDMWLA AENGMFLRLT KGEWMTTMPE HLNMEWVDSV KHVFEYFTER 720 TPRSHFDKRE TSLVWNYKYA DVDFGRLQAR DMLQHLWTGP ISNASVDVVQ GSRSVEVRAV 780 GVTKGAAIDR ILGEIVHSKS MTSPIDYVLC IGHFLGKDED VYTFFEPDLP FEPIGLPRTK 840 ISDGLKPNER RSSLKAPAIK GGSKSSQSKA QRLXPNSEKK NANHNTTNPR WPSPEKISWN 900 VLDLKKENYY SCSVGRTRTN ARYLLQSSDD VVSFLKELAG ASSASVSSSD |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
PLN03064 | PLN03064 | 0 | 1 | 938 | 951 | + alpha,alpha-trehalose-phosphate synthase (UDP-forming); Provisional | ||
PLN03063 | PLN03063 | 0 | 80 | 938 | 859 | + alpha,alpha-trehalose-phosphate synthase (UDP-forming); Provisional | ||
PRK14501 | PRK14501 | 0 | 85 | 812 | 735 | + putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional | ||
TIGR02400 | trehalose_OtsA | 0 | 85 | 576 | 494 | + alpha,alpha-trehalose-phosphate synthase [UDP-forming]. This enzyme catalyzes the key, penultimate step in biosynthesis of trehalose, a compatible solute made as an osmoprotectant in some species in all three domains of life. The gene symbol OtsA stands for osmotically regulated trehalose synthesis A. Trehalose helps protect against both osmotic and thermal stresses, and is made from two glucose subunits. This model excludes glucosylglycerol-phosphate synthase, an enzyme of an analogous osmoprotectant system in many cyanobacterial strains. This model does not identify archaeal examples, as they are more divergent than glucosylglycerol-phosphate synthase. Sequences that score in the gray zone between the trusted and noise cutoffs include a number of yeast multidomain proteins in which the N-terminal domain may be functionally equivalent to this family. The gray zone also includes the OtsA of Cornyebacterium glutamicum (and related species), shown to be responsible for synthesis of only trace amounts of trehalose while the majority is synthesized by the TreYZ pathway; the significance of OtsA in this species is unclear (see Wolf, et al., PMID:12890033) [Cellular processes, Adaptations to atypical conditions]. | ||
pfam00982 | Glyco_transf_20 | 0 | 85 | 576 | 498 | + Glycosyltransferase family 20. Members of this family belong to glycosyl transferase family 20. OtsA (Trehalose-6-phosphate synthase) is homologous to regions in the subunits of yeast trehalose-6-phosphate synthase/phosphate complex. |
Gene Ontology | |
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GO Term | Description |
GO:0003824 | catalytic activity |
GO:0005992 | trehalose biosynthetic process |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | ABO61742.1 | 0 | 1 | 948 | 1 | 926 | trehalose-phosphate synthase 1 [Solanum lycopersicum] |
RefSeq | NP_177979.1 | 0 | 1 | 944 | 1 | 941 | ATTPS1 (TREHALOSE-6-PHOSPHATE SYNTHASE); alpha,alpha-trehalose-phosphate synthase (UDP-forming)/ transferase, transferring glycosyl groups [Arabidopsis thaliana] |
RefSeq | XP_002285632.1 | 0 | 1 | 944 | 1 | 926 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002331300.1 | 0 | 1 | 943 | 1 | 922 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002531237.1 | 0 | 1 | 945 | 1 | 926 | trehalose-6-phosphate synthase, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 2wtx_D | 0 | 85 | 586 | 3 | 466 | A Chain A, Insight Into The Mechanism Of Enzymatic Glycosyltransfer With Retention Through The Synthesis And Analysis Of Bisubstrate Glycomimetics Of Trehalose-6-Phosphate Synthase |
PDB | 2wtx_C | 0 | 85 | 586 | 3 | 466 | A Chain A, Insight Into The Mechanism Of Enzymatic Glycosyltransfer With Retention Through The Synthesis And Analysis Of Bisubstrate Glycomimetics Of Trehalose-6-Phosphate Synthase |
PDB | 2wtx_B | 0 | 85 | 586 | 3 | 466 | A Chain A, Insight Into The Mechanism Of Enzymatic Glycosyltransfer With Retention Through The Synthesis And Analysis Of Bisubstrate Glycomimetics Of Trehalose-6-Phosphate Synthase |
PDB | 2wtx_A | 0 | 85 | 586 | 3 | 466 | A Chain A, Insight Into The Mechanism Of Enzymatic Glycosyltransfer With Retention Through The Synthesis And Analysis Of Bisubstrate Glycomimetics Of Trehalose-6-Phosphate Synthase |
PDB | 1uqu_B | 0 | 85 | 586 | 3 | 466 | A Chain A, Trehalose-6-Phosphate From E. Coli Bound With Udp-Glucose. |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
CX546763 | 315 | 61 | 374 | 0 |
CV711307 | 294 | 82 | 375 | 0 |
ES813375 | 355 | 476 | 830 | 0 |
DW069910 | 286 | 171 | 456 | 0 |
CB651133 | 281 | 111 | 391 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
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