Basic Information | |
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Species | Malus domestica |
Cazyme ID | MDP0000269370 |
Family | AA3 |
Protein Properties | Length: 420 Molecular Weight: 45933.5 Isoelectric Point: 7.7788 |
Chromosome | Chromosome/Scaffold: 001587248 Start: 22021 End: 24483 |
Description | Glucose-methanol-choline (GMC) oxidoreductase family protein |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
AA3 | 129 | 403 | 8.9e-37 |
GHLTGVFANAEVILSAGTLGTPQLLLXSGIGPESYLSSLNITVVRDHPFVGQFVYDNPRNFINIVPPNPIEASIVTVLGITDYFYQCSLSSMPLTTPAYS LFPTPLVVNSTFTHIPSKIPGPXSHGSLTLNSSSDVRXXPNVRFNYFLDPTDLAHCVSAMKNTXDLLMTDALKPYKAQDLPGMEGFNFLGQPLPKNQTDD ASFETFCRDTVASYWHYHGGCLVGKVVDCSFRLNGIYGLRVADATLFPAAPASHPQXFYLMLGRYVGLQILKERS |
Full Sequence |
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Protein Sequence Length: 420 Download |
MGVAGDGGRA PSXGRYGCGR VGYGGGCIAN QNVEKTDWDL RDWGKWRLWW TGGPELLHKM 60 GLNKADVGQG CLNIHQVGLK GLLAGGQQRH GVMESVELLK DLVLLILXLK IGIRDVCQLQ 120 ESYTVILTGH LTGVFANAEV ILSAGTLGTP QLLLXSGIGP ESYLSSLNIT VVRDHPFVGQ 180 FVYDNPRNFI NIVPPNPIEA SIVTVLGITD YFYQCSLSSM PLTTPAYSLF PTPLVVNSTF 240 THIPSKIPGP XSHGSLTLNS SSDVRXXPNV RFNYFLDPTD LAHCVSAMKN TXDLLMTDAL 300 KPYKAQDLPG MEGFNFLGQP LPKNQTDDAS FETFCRDTVA SYWHYHGGCL VGKVVDCSFR 360 LNGIYGLRVA DATLFPAAPA SHPQXFYLML GRYVGLQILK ERSTXGNSLT RHHPVPFKLK 420 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
TIGR03970 | Rv0697 | 9.0e-15 | 140 | 391 | 263 | + dehydrogenase, Rv0697 family. This model describes a set of dehydrogenases belonging to the glucose-methanol-choline oxidoreductase (GMC oxidoreductase) family. Members of the present family are restricted to Actinobacterial genome contexts containing also members of families TIGR03962 and TIGR03969 (the mycofactocin system), and are proposed to be uniform in function. | ||
TIGR01810 | betA | 6.0e-21 | 129 | 376 | 281 | + choline dehydrogenase. Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli , Staphylococcus xylosus , and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified [Cellular processes, Adaptations to atypical conditions]. | ||
pfam05199 | GMC_oxred_C | 5.0e-23 | 250 | 391 | 147 | + GMC oxidoreductase. This domain found associated with pfam00732. | ||
COG2303 | BetA | 4.0e-24 | 129 | 402 | 303 | + Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism] | ||
PLN02785 | PLN02785 | 2.0e-59 | 138 | 402 | 304 | + Protein HOTHEAD |
Gene Ontology | |
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GO Term | Description |
GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors |
GO:0050660 | flavin adenine dinucleotide binding |
GO:0055114 | oxidation-reduction process |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | AAC61982.1 | 0 | 130 | 403 | 271 | 546 | (R)-(+)-mandelonitrile lyase isoform MDL5 precursor [Prunus serotina] |
GenBank | AAP84580.1 | 0 | 130 | 403 | 271 | 546 | hnl isoenzyme 5 [Prunus dulcis] |
GenBank | ACY69987.1 | 0 | 134 | 420 | 268 | 551 | mandelonitrile lyase 1 [Eriobotrya japonica] |
GenBank | ACY69988.1 | 0 | 134 | 394 | 268 | 528 | mandelonitrile lyase 2 [Eriobotrya japonica] |
Swiss-Prot | P52706 | 0 | 128 | 403 | 268 | 545 | MDL1_PRUSE RecName: Full=(R)-mandelonitrile lyase 1; AltName: Full=Hydroxynitrile lyase 1; Short=(R)-oxynitrilase 1; Flags: Precursor |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 1ju2_B | 0 | 128 | 403 | 241 | 518 | A Chain A, Crystal Structure Of The Hydroxynitrile Lyase From Almond |
PDB | 1ju2_A | 0 | 128 | 403 | 241 | 518 | A Chain A, Crystal Structure Of The Hydroxynitrile Lyase From Almond |
PDB | 3gdp_B | 0 | 128 | 403 | 241 | 518 | A Chain A, Crystal Structure Of The Hydroxynitrile Lyase From Almond |
PDB | 3gdp_A | 0 | 128 | 403 | 241 | 518 | A Chain A, Crystal Structure Of The Hydroxynitrile Lyase From Almond |
PDB | 3gdn_B | 0 | 128 | 403 | 241 | 518 | A Chain A, Almond Hydroxynitrile Lyase In Complex With Benzaldehyde |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
BU574120 | 214 | 179 | 389 | 0 |
BU574474 | 212 | 195 | 403 | 0 |
BU575280 | 196 | 128 | 320 | 0 |
BU572692 | 186 | 221 | 403 | 0 |
DW341064 | 204 | 194 | 394 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
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