Basic Information | |
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Species | Malus domestica |
Cazyme ID | MDP0000270244 |
Family | GT51 |
Protein Properties | Length: 981 Molecular Weight: 107973 Isoelectric Point: 6.1275 |
Chromosome | Chromosome/Scaffold: 000086306 Start: 5197 End: 10071 |
Description | S-locus lectin protein kinase family protein |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT51 | 788 | 896 | 2.6e-37 |
SQQLVKNTFLKNERTFSRKLVEMVLSLALERTMSKGEILSCYTSKIYWGHGIYGVESASAFYFGKHPSCLSLGESSMLAGLIPAPELRSPLRDPSRGKTF QARVLKRMV |
Full Sequence |
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Protein Sequence Length: 981 Download |
MGSFLFIPTV FLPFLLFILV SGGSFSEFIY PDFSASHFHF IDNAGAFLSS RNGTFKAAIV 60 NPDANQLNFY LCIIHTASNT IIWTANRDAS ISASAEMNLT AKGISISDDD GNPVWSTPQF 120 KSSVSALLLN EMGNLILLDQ FNRSLWESFQ NATDTIVNGQ HLPVGSFLSS TLSNFSTGDY 180 RLVLSGSDAI LQWHGQTYWK LSMDTSAYTN SNTIVEYMAI NGRGLQLLGR NGTVVVIQVL 240 LSPSEFRIAK LDSSGKFIVQ RFSGTDWKQE FVGPADLVCV LHPPPIVVHA LQTSLLDYGT 300 DYFSNIFSDP VRYGVNLSTC QDLCSKDCSC LGIFYGNSSG SCYTLKDDLG SIFVSESAQN 360 DLLGYIKALV GSSPSNFSDN KNPSRKKFPV VALVLLPFSG FFLLVALGFL LWGRRGQSKK 420 RDTKLGHFGS LSSGDMDAFY IPGLPRRFDL EELEVATDGF KTLIGSGGFG AVYKAVLPDK 480 XVVAVKKIMN LGVQGKKDFC TEIAIIGNIH HANLMNRGSL DRSLFGTGPV LEWQERLDIA 540 LGTARGLAYL HSGCEQKIIH CDVKPENILL HDQFQAKISD FGLSKLLTPE QSSLFTTMRG 600 TRGYLAPEWL TNSAISEXTD VYSFGMVLLE LVSGRKNTLR LQSHSLNNSG SGGGQSSSSS 660 VSLLVYFPLF ALEMHEQGRY LELVDLRLEG RVTSEEVEKF VRVALCCVQE DPTLRPSMNT 720 VVGMLEGGIP LGQPNLESLN FLRFIGRGFA EASMIDEGTD QNDRVLYPEA YASTATMGSR 780 TFFSYVSSQQ LVKNTFLKNE RTFSRKLVEM VLSLALERTM SKGEILSCYT SKIYWGHGIY 840 GVESASAFYF GKHPSCLSLG ESSMLAGLIP APELRSPLRD PSRGKTFQAR VLKRMVDVGY 900 LDIETALSVM KQYLPLQVNE SEAPIVLPPG GGRNSKFKDI WDWETESKIL EACEDMDRWA 960 INVLHTTSPN SLVHPITGCD L |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
smart00220 | S_TKc | 3.0e-39 | 463 | 635 | 194 | + Serine/Threonine protein kinases, catalytic domain. Phosphotransferases. Serine or threonine-specific kinase subfamily. | ||
TIGR02074 | PBP_1a_fam | 1.0e-39 | 788 | 924 | 137 | + penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]. | ||
cd00180 | PKc | 3.0e-40 | 464 | 631 | 191 | + Catalytic domain of Protein Kinases. Protein Kinases (PKs), catalytic (c) domain. PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. The PK family is part of a larger superfamily that includes the catalytic domains of RIO kinases, aminoglycoside phosphotransferase, choline kinase, phosphoinositide 3-kinase (PI3K), and actin-fragmin kinase. PKs make up a large family of serine/threonine kinases, protein tyrosine kinases (PTKs), and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins. Majority of protein phosphorylation, about 95%, occurs on serine residues while only 1% occurs on tyrosine residues. Protein phosphorylation is a mechanism by which a wide variety of cellular proteins, such as enzymes and membrane channels, are reversibly regulated in response to certain stimuli. PKs often function as components of signal transduction pathways in which one kinase activates a second kinase, which in turn, may act on other kinases; this sequential action transmits a signal from the cell surface to target proteins, which results in cellular responses. The PK family is one of the largest known protein families with more than 100 homologous yeast enzymes and 550 human proteins. A fraction of PK family members are pseudokinases that lack crucial residues for catalytic activity. The mutiplicity of kinases allows for specific regulation according to substrate, tissue distribution, and cellular localization. PKs regulate many cellular processes including proliferation, division, differentiation, motility, survival, metabolism, cell-cycle progression, cytoskeletal rearrangement, immunity, and neuronal functions. Many kinases are implicated in the development of various human diseases including different types of cancer. | ||
pfam00069 | Pkinase | 1.0e-41 | 464 | 718 | 287 | + Protein kinase domain. | ||
pfam00912 | Transgly | 4.0e-44 | 788 | 896 | 109 | + Transglycosylase. The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerisation of murein glycan chains. |
Gene Ontology | |
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GO Term | Description |
GO:0003824 | catalytic activity |
GO:0004672 | protein kinase activity |
GO:0005524 | ATP binding |
GO:0005529 | Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] |
GO:0006468 | protein phosphorylation |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
DDBJ | BAB11487.1 | 0 | 17 | 791 | 18 | 832 | S-receptor kinase [Arabidopsis thaliana] |
EMBL | CAN72729.1 | 0 | 30 | 758 | 174 | 956 | hypothetical protein [Vitis vinifera] |
EMBL | CAN72729.1 | 6e-40 | 831 | 963 | 951 | 1099 | hypothetical protein [Vitis vinifera] |
RefSeq | XP_002284416.1 | 0 | 1 | 791 | 181 | 1045 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002513778.1 | 0 | 74 | 791 | 1 | 789 | s-receptor kinase, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3ulz_A | 0 | 443 | 727 | 15 | 308 | A Chain A, Crystal Structure Of Medicago Truncatula Ugt71g1 Complexed With Udp-Glucose |
PDB | 3uim_A | 0 | 443 | 727 | 15 | 308 | A Chain A, Structural Basis For The Impact Of Phosphorylation On Plant Receptor- Like Kinase Bak1 Activation |
PDB | 3tl8_H | 0 | 420 | 727 | 1 | 316 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
PDB | 3tl8_G | 0 | 420 | 727 | 1 | 316 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
PDB | 3tl8_D | 0 | 420 | 727 | 1 | 316 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
Transmembrane Domains | ||||
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Start | End | |||
4 | 26 | |||
390 | 412 |
Signal Peptide | ||||
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Cleavage Site | ||||
22 |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
BQ623780 | 192 | 515 | 706 | 0 |
DN498533 | 182 | 475 | 637 | 0 |
BQ629746 | 183 | 474 | 637 | 0 |
EE172103 | 211 | 442 | 632 | 0 |
EG555403 | 193 | 523 | 713 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
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