| Basic Information | |
|---|---|
| Species | Malus domestica |
| Cazyme ID | MDP0000271120 |
| Family | GH29 |
| Protein Properties | Length: 577 Molecular Weight: 66020 Isoelectric Point: 7.1156 |
| Chromosome | Chromosome/Scaffold: 003154278 Start: 26307 End: 29797 |
| Description | alpha-L-fucosidase 1 |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH29 | 42 | 376 | 0 |
| QLKWQQREIIMFLHFGVNTFTGFERGTGHESPGIFNPVGLDANQWAXTASDAGISLMILTAKHHDGFCLWPSKYTDHSVAXSPWXNGHGDVVHELVDAAN RRGIDVGFYLSPWDRHDQRYGHEIAYNQYYLAQLQELLNRYGGVKEIWFDGYKGKSAPNMSYYFTDWFSMVKELQSSINIFSDAGPDARWVGNEEGFAGS TCWSTINRTSLSIGNASIEEWVPFFAFYSRKFTFLLFVIRFHHYDRLRVGFLSIYDYYLNKGDPKGTDWLPAECDVSIRDGWFWHKSESPKRLSKLLEIY YNSVGRNSVLLLNVPPNSTGLIADEDVQRLREFRS | |||
| Full Sequence |
|---|
| Protein Sequence Length: 577 Download |
| MAKLWCSLCV ITFFQLCTFT FSKFEQVSTP PLPILPLPTY LQLKWQQREI IMFLHFGVNT 60 FTGFERGTGH ESPGIFNPVG LDANQWAXTA SDAGISLMIL TAKHHDGFCL WPSKYTDHSV 120 AXSPWXNGHG DVVHELVDAA NRRGIDVGFY LSPWDRHDQR YGHEIAYNQY YLAQLQELLN 180 RYGGVKEIWF DGYKGKSAPN MSYYFTDWFS MVKELQSSIN IFSDAGPDAR WVGNEEGFAG 240 STCWSTINRT SLSIGNASIE EWVPFFAFYS RKFTFLLFVI RFHHYDRLRV GFLSIYDYYL 300 NKGDPKGTDW LPAECDVSIR DGWFWHKSES PKRLSKLLEI YYNSVGRNSV LLLNVPPNST 360 GLIADEDVQR LREFRSAIDT IFSTNLAEKC SIEVSSQRGG KGGGFEPENM LDNDHLWTYW 420 APRDDEKENH WIEFISTRLD EGLRFNVIRI QEAIGLGQRI KRHIIYVDGK RVANGTTVGY 480 KRLHRLEGGV VHGKIGFLDA NGHFRQAIYL AKTLLRHHPV DNFAEPSLLL TLISSGQVSF 540 GKQVFASYDS MLQLAASFVF HGEHNTGRNS YWLAKLL |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam01120 | Alpha_L_fucos | 1.0e-25 | 76 | 243 | 181 | + Alpha-L-fucosidase. | ||
| smart00812 | Alpha_L_fucos | 1.0e-25 | 76 | 192 | 131 | + Alpha-L-fucosidase. O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in 'clans'. Family 29 encompasses alpha-L-fucosidases, which is a lysosomal enzyme responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. Deficiency of alpha-L-fucosidase results in the lysosomal storage disease fucosidosis. | ||
| COG3669 | COG3669 | 3.0e-45 | 45 | 492 | 463 | + Alpha-L-fucosidase [Carbohydrate transport and metabolism] | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0004560 | alpha-L-fucosidase activity |
| GO:0005975 | carbohydrate metabolic process |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| RefSeq | XP_002270630.1 | 0 | 42 | 502 | 23 | 445 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002270674.1 | 0 | 27 | 502 | 5 | 444 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002318264.1 | 0 | 1 | 495 | 1 | 455 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002322431.1 | 0 | 1 | 494 | 1 | 455 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002510887.1 | 0 | 1 | 500 | 1 | 464 | alpha-l-fucosidase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3eyp_B | 0 | 33 | 486 | 5 | 427 | A Chain A, Crystal Structure Of Putative Alpha-L-Fucosidase From Bacteroides Thetaiotaomicron |
| PDB | 3eyp_A | 0 | 33 | 486 | 5 | 427 | A Chain A, Crystal Structure Of Putative Alpha-L-Fucosidase From Bacteroides Thetaiotaomicron |
| PDB | 3ues_B | 0 | 38 | 487 | 19 | 450 | A Chain A, Crystal Structure Of Alpha-1,34-Fucosidase From Bifidobacterium Longum Subsp. Infantis Complexed With Deoxyfuconojirimycin |
| PDB | 3ues_A | 0 | 38 | 487 | 19 | 450 | A Chain A, Crystal Structure Of Alpha-1,34-Fucosidase From Bifidobacterium Longum Subsp. Infantis Complexed With Deoxyfuconojirimycin |
| PDB | 3mo4_B | 0 | 38 | 487 | 21 | 452 | A Chain A, The Crystal Structure Of An Alpha-(1-3,4)-Fucosidase From Bifidobacterium Longum Subsp. Infantis Atcc 15697 |
