y
Basic Information | |
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Species | Malus domestica |
Cazyme ID | MDP0000279572 |
Family | GT47 |
Protein Properties | Length: 531 Molecular Weight: 60608.8 Isoelectric Point: 9.4797 |
Chromosome | Chromosome/Scaffold: 00783976 Start: 24879 End: 27634 |
Description | Exostosin family protein |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 111 | 453 | 0 |
MRVYVYDMPSKFTYDLLWLFRNSYKETFNLTSNGSPVHRLIEQHSIDYWLWADLIAPESERLLKSVVRVHRQEEADLFYIPFFTTISFFLLEKQQCKALY REVVKWVTDQPAWNRSQGRDHILPVHHPWSFKSVRRLMKNAIWLLPDMDSTGNWSLFHFISFLSSKFTKDHYSAQAGLTLFCSTYRYKPGQVYLEKDLIL PYVANVDFCDARCISETRSKRTTLLFFRGRLKRNAGGKIRSQLVAELSGSEGVAIEEGTAGEAGKSAAQNGMRKSVFCLSPAGDTPSSARLFDAIVSGCI PVIVSDELELPFEGILDYRKIALFISSSDAVRPGWLVTFLRNI |
Full Sequence |
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Protein Sequence Length: 531 Download |
MARSKSPVLL MLLALLALSL IFLLFSFHSP STADPSAILH PNQPTYKPET SFVASLERFL 60 LAHKSRPSKP RDDTVLTTPT QSQLKHLDDL VFQSDSHRLY ADPYYPLSLP MRVYVYDMPS 120 KFTYDLLWLF RNSYKETFNL TSNGSPVHRL IEQHSIDYWL WADLIAPESE RLLKSVVRVH 180 RQEEADLFYI PFFTTISFFL LEKQQCKALY REVVKWVTDQ PAWNRSQGRD HILPVHHPWS 240 FKSVRRLMKN AIWLLPDMDS TGNWSLFHFI SFLSSKFTKD HYSAQAGLTL FCSTYRYKPG 300 QVYLEKDLIL PYVANVDFCD ARCISETRSK RTTLLFFRGR LKRNAGGKIR SQLVAELSGS 360 EGVAIEEGTA GEAGKSAAQN GMRKSVFCLS PAGDTPSSAR LFDAIVSGCI PVIVSDELEL 420 PFEGILDYRK IALFISSSDA VRPGWLVTFL RNISHAQIEE MRQNLAKYSR HFLYSSPAQP 480 LGPEDLVWRM MAGKLVNIKL QTRRSQRVVK ESRSVCTCDC KRANSTIAGH L 540 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 1.0e-64 | 110 | 453 | 352 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI20132.1 | 0 | 118 | 526 | 1 | 377 | unnamed protein product [Vitis vinifera] |
RefSeq | NP_197191.1 | 0 | 2 | 522 | 13 | 497 | exostosin family protein [Arabidopsis thaliana] |
RefSeq | XP_002285599.1 | 0 | 45 | 526 | 59 | 511 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002325382.1 | 0 | 31 | 527 | 37 | 502 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002520033.1 | 0 | 45 | 526 | 53 | 502 | catalytic, putative [Ricinus communis] |