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Basic Information | |
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Species | Malus domestica |
Cazyme ID | MDP0000282003 |
Family | GT14 |
Protein Properties | Length: 954 Molecular Weight: 108279 Isoelectric Point: 5.8326 |
Chromosome | Chromosome/Scaffold: 006465419 Start: 8202 End: 16334 |
Description | calcium-dependent protein kinase 24 |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT14 | 610 | 866 | 0 |
LAYLISGTKGDSHRMMRTLSAVYHPRNQYILHLDLEAPPRERLELASLVKADLTFREVENVRVMSQSNLVTYKGPTMIACTLQAISILLKESSEWDWFIN LSASDYPLMTQDDLLHAFSNISRNINFIEHMQLTGWKLNQRAKPIIIDPGLYLSKKSDLASTTQRRSLPTSFKLFTGSAWVMLTRSFLEYCIWGWDNLPR TMLMYYTNFVSSPEGYFHTIICDNEEYRHTAISHDLHYIAWDSPPKQHPISLSMKDF |
Full Sequence |
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Protein Sequence Length: 954 Download |
MGSCVCTPAK AGFHHRRRDI IKPLPQSSVH DSSPRRSFVA PVPHHSTIIW VLDKTAGNDI 60 FGKYQFGNEL GRGEFGITYR CVHRETGEAF ACKTISKSKL KTEIDVEDVR REAEIMRRLP 120 KHPNIVCFKE AYEDREAVYL VMELCEGGEL FDRIVAKGHY TERAAATVCH KHGVIHRDLK 180 PENFLFADGS ENAELKAIDF GLSIFFEPGQ RFNEIVGSPY YMAPEVLRRN YGPEVDVWSS 240 GVILYILLCG VPPFWAETEE GIAQAIVRGT IDFERETWKN VSEEAKELVR SMLDPNPCNR 300 LKVEEVLDHP WIXNGNQVPN VPLGENVTLR IKQFSLMNKF KKKVLRVVAD NLPEDQIDGI 360 RQIFEMMDID NNGNLTFEEL RDGLVKIGHN VADPDVQMLL DAADADGNGT LSCDEFVMVS 420 VHLKKIDSDE FLHQAFGYFD KNNSGYIEFD ELREALLDDK LGPDNEQVIQ DIIFDVDLDK 480 DGRIGFEEFK AMMKTGMDWK MASRQYSRAL LNVLSLNSFH TKEVADDFWE SRVIGDRIWA 540 IPFIASFIIF ITLFFSAISG IFTAPHAGEK LSFDIIPFSK PDDSSGYFVE SDLKRSLDTN 600 GGSKSGAPSL AYLISGTKGD SHRMMRTLSA VYHPRNQYIL HLDLEAPPRE RLELASLVKA 660 DLTFREVENV RVMSQSNLVT YKGPTMIACT LQAISILLKE SSEWDWFINL SASDYPLMTQ 720 DDLLHAFSNI SRNINFIEHM QLTGWKLNQR AKPIIIDPGL YLSKKSDLAS TTQRRSLPTS 780 FKLFTGSAWV MLTRSFLEYC IWGWDNLPRT MLMYYTNFVS SPEGYFHTII CDNEEYRHTA 840 ISHDLHYIAW DSPPKQHPIS LSMKDFDKMV KSNAPFARKF AKDDPVLDKI DKELLGRTNR 900 FAPGGWCIGS PEGGADPCSV RGNDSVFKPG PGSGRFQELL HTLLSEDFRK KQCT 960 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
cd05123 | STKc_AGC | 9.0e-65 | 70 | 311 | 258 | + Catalytic domain of AGC family Protein Serine/Threonine Kinases. Serine/Threonine Kinases (STKs), AGC (Protein Kinases A, G and C) family, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The AGC family is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and Phosphoinositide 3-Kinase (PI3K). Members of this family include cAMP-dependent Protein Kinase (PKA), cGMP-dependent Protein Kinase (PKG), Protein Kinase C (PKC), Protein Kinase B (PKB), G protein-coupled Receptor Kinase (GRK), Serum- and Glucocorticoid-induced Kinase (SGK), and 70 kDa ribosomal Protein S6 Kinase (p70S6K or S6K), among others. AGC kinases share an activation mechanism based on the phosphorylation of up to three sites: the activation loop (A-loop), the hydrophobic motif (HM) and the turn motif. Phosphorylation at the A-loop is required of most AGC kinases, which results in a disorder-to-order transition of the A-loop. The ordered conformation results in the access of substrates and ATP to the active site. A subset of AGC kinases with C-terminal extensions containing the HM also requires phosphorylation at this site. Phosphorylation at the HM allows the C-terminal extension to form an ordered structure that packs into the hydrophobic pocket of the catalytic domain, which then reconfigures the kinase into an active bi-lobed state. In addition, growth factor-activated AGC kinases such as PKB, p70S6K, RSK, MSK, PKC, and SGK, require phosphorylation at the turn motif (also called tail or zipper site), located N-terminal to the HM at the C-terminal extension. AGC kinases regulate many cellular processes including division, growth, survival, metabolism, motility, and differentiation. Many are implicated in the development of various human diseases. | ||
pfam02485 | Branch | 4.0e-75 | 610 | 870 | 265 | + Core-2/I-Branching enzyme. This is a family of two different beta-1,6-N-acetylglucosaminyltransferase enzymes, I-branching enzyme and core-2 branching enzyme . I-branching enzyme is responsible for the production of the blood group I-antigen during embryonic development. Core-2 branching enzyme forms crucial side-chain branches in O-glycans. | ||
pfam00069 | Pkinase | 2.0e-83 | 64 | 312 | 265 | + Protein kinase domain. | ||
smart00220 | S_TKc | 5.0e-93 | 64 | 312 | 261 | + Serine/Threonine protein kinases, catalytic domain. Phosphotransferases. Serine or threonine-specific kinase subfamily. | ||
PLN03183 | PLN03183 | 0 | 573 | 953 | 383 | + acetylglucosaminyltransferase family protein; Provisional |
Gene Ontology | |
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GO Term | Description |
GO:0004672 | protein kinase activity |
GO:0005524 | ATP binding |
GO:0006468 | protein phosphorylation |
GO:0008375 | acetylglucosaminyltransferase activity |
GO:0016020 | membrane |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI36647.1 | 0 | 49 | 524 | 62 | 547 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002264388.1 | 0 | 49 | 524 | 40 | 525 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002309814.1 | 0 | 1 | 517 | 1 | 524 | calcium dependent protein kinase 24 [Populus trichocarpa] |
RefSeq | XP_002517977.1 | 0 | 527 | 954 | 12 | 439 | acetylglucosaminyltransferase, putative [Ricinus communis] |
RefSeq | XP_002533526.1 | 0 | 1 | 516 | 1 | 521 | calcium-dependent protein kinase, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3v5t_A | 0 | 63 | 493 | 27 | 478 | A Chain A, Crystal Structure Of Aqpz F43w,H174g,T183f |
PDB | 3v5p_A | 0 | 63 | 493 | 27 | 478 | A Chain A, Crystal Structure Of Aqpz F43w,H174g,T183f |
PDB | 3v51_A | 0 | 63 | 493 | 27 | 478 | A Chain A, Crystal Structure Of Aqpz F43w,H174g,T183f |
PDB | 3upz_A | 0 | 63 | 493 | 27 | 478 | A Chain A, Crystal Structure Of Aqpz F43w,H174g,T183f |
PDB | 3upx_A | 0 | 63 | 493 | 27 | 478 | A Chain A, Crystal Structure Of Aqpz F43w,H174g,T183f |