| Basic Information | |
|---|---|
| Species | Malus domestica |
| Cazyme ID | MDP0000295518 |
| Family | GH29 |
| Protein Properties | Length: 466 Molecular Weight: 52520.3 Isoelectric Point: 5.8737 |
| Chromosome | Chromosome/Scaffold: 012040386 Start: 5089 End: 8843 |
| Description | alpha-L-fucosidase 1 |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH29 | 2 | 289 | 0 |
| AMFLHFGPNTFTDSEWGTGHVDPSVFNPAKLNAAQWVRVAKDSGFSRVILTAKHHDGFCLWPTEYTNYSVSSSPWRSGGGDVVGELAAAARDAGIGLGLY LSPWDRHEPCYGKTLEYNEFYMGQMTELLTRYGEIKEVWLDGAKGEGEKDMEYFFDSWFSLIHQHQPGAVIFSDAGPDTRWVGDEAGVAGSTCWSLFNRS DAKIGDTDYQYSNGGDPFGHDWVPAECDVSIRPGWFWHSLEVPKSARTLLDLYYKSXGRNCLLLLNVPPNXSGLISAEDIQVLQEFND | |||
| Full Sequence |
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| Protein Sequence Length: 466 Download |
| MAMFLHFGPN TFTDSEWGTG HVDPSVFNPA KLNAAQWVRV AKDSGFSRVI LTAKHHDGFC 60 LWPTEYTNYS VSSSPWRSGG GDVVGELAAA ARDAGIGLGL YLSPWDRHEP CYGKTLEYNE 120 FYMGQMTELL TRYGEIKEVW LDGAKGEGEK DMEYFFDSWF SLIHQHQPGA VIFSDAGPDT 180 RWVGDEAGVA GSTCWSLFNR SDAKIGDTDY QYSNGGDPFG HDWVPAECDV SIRPGWFWHS 240 LEVPKSARTL LDLYYKSXGR NCLLLLNVPP NXSGLISAED IQVLQEFNDL RKSIFSYNLA 300 KTALINASST RGGSNNSWFT PSNVVQEGID SYWAPEGNQS KWVLSLNLQK LVSFNILQVQ 360 EPIQMGQRVI EFHLEVLNEE RKWNKVINGT TIGYQRLLQF PTVKSQYLRF VIDKSRADPL 420 ISYLGLYIDR YSILSNLSHT TSHASRNRSQ ILNYHIESNH SQVAAI |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam00754 | F5_F8_type_C | 0.003 | 305 | 417 | 119 | + F5/8 type C domain. This domain is also known as the discoidin (DS) domain family. | ||
| pfam01120 | Alpha_L_fucos | 3.0e-35 | 3 | 287 | 323 | + Alpha-L-fucosidase. | ||
| smart00812 | Alpha_L_fucos | 5.0e-36 | 27 | 287 | 282 | + Alpha-L-fucosidase. O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in 'clans'. Family 29 encompasses alpha-L-fucosidases, which is a lysosomal enzyme responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. Deficiency of alpha-L-fucosidase results in the lysosomal storage disease fucosidosis. | ||
| COG3669 | COG3669 | 3.0e-63 | 4 | 427 | 435 | + Alpha-L-fucosidase [Carbohydrate transport and metabolism] | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0004560 | alpha-L-fucosidase activity |
| GO:0005975 | carbohydrate metabolic process |
| GO:0007155 | cell adhesion |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| RefSeq | NP_180377.2 | 0 | 1 | 432 | 50 | 482 | ATFUC1 (alpha-L-fucosidase 1); alpha-L-fucosidase [Arabidopsis thaliana] |
| Swiss-Prot | Q8GW72 | 0 | 1 | 432 | 50 | 482 | FUCO1_ARATH RecName: Full=Alpha-L-fucosidase 1; AltName: Full=Alpha-L-fucoside fucohydrolase; AltName: Full=Alpha-1,3/4-fucosidase; Short=AtFUC1; Flags: Precursor |
| RefSeq | XP_002276131.1 | 0 | 1 | 466 | 62 | 545 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002313533.1 | 0 | 1 | 432 | 26 | 457 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002523703.1 | 0 | 1 | 452 | 75 | 528 | alpha-l-fucosidase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3ues_B | 0 | 1 | 422 | 31 | 471 | A Chain A, Crystal Structure Of Alpha-1,34-Fucosidase From Bifidobacterium Longum Subsp. Infantis Complexed With Deoxyfuconojirimycin |
| PDB | 3ues_A | 0 | 1 | 422 | 31 | 471 | A Chain A, Crystal Structure Of Alpha-1,34-Fucosidase From Bifidobacterium Longum Subsp. Infantis Complexed With Deoxyfuconojirimycin |
| PDB | 3mo4_B | 0 | 1 | 422 | 33 | 473 | A Chain A, The Crystal Structure Of An Alpha-(1-3,4)-Fucosidase From Bifidobacterium Longum Subsp. Infantis Atcc 15697 |
| PDB | 3mo4_A | 0 | 1 | 422 | 33 | 473 | A Chain A, The Crystal Structure Of An Alpha-(1-3,4)-Fucosidase From Bifidobacterium Longum Subsp. Infantis Atcc 15697 |
| PDB | 3uet_B | 0 | 1 | 422 | 31 | 471 | A Chain A, Crystal Structure Of Alpha-1,34-Fucosidase From Bifidobacterium Longum Subsp. Infantis D172aE217A MUTANT COMPLEXED WITH LACTO-N- Fucopentaose Ii |
| Hydropathy |
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| EST Download unfiltered results here | ||||
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| Hit | Length | Start | End | EValue |
| DY270181 | 279 | 1 | 279 | 0 |
| DY300194 | 284 | 18 | 301 | 0 |
| DY291901 | 274 | 1 | 274 | 0 |
| DY272403 | 347 | 1 | 341 | 0 |
| DY300194 | 24 | 1 | 24 | 0.0002 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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