| Basic Information | |
|---|---|
| Species | Malus domestica |
| Cazyme ID | MDP0000311272 |
| Family | GT47 |
| Protein Properties | Length: 1077 Molecular Weight: 120785 Isoelectric Point: 5.8024 |
| Chromosome | Chromosome/Scaffold: 01925845 Start: 36571 End: 48056 |
| Description | exostosin family protein |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
 | |||
| Family | Start | End | Evalue |
| GT47 | 309 | 577 | 0 |
| DDQNSTLWTDQLYGAQMALYESILASPHRTLNGDEADFFFVPVLDSCIITRADDGACYAPKEIWNSTMLVHWGNTNSKHKHSTTAYWADNWNEISSXKRG NHPCFDPDKDLVLPAWKSPDVNSLSSKLWSRSXESRKTLFYFNGNLGPAYPNGRPEASYSMGIRQKLAEEFGSSPXKEGKLGKQHAEDVIVTPLRAENYH LDLAXSIFCGVFPGDGWSGRMEDSILQGCIPVVIQDGIFLPYENVLNYESFAVRISEDEIPNLINILRA | |||
| Full Sequence |
|---|
| Protein Sequence Length: 1077 Download |
| MMLPIXKWKC SGSQIATVAS VVAXVSIVLV SMVHLFWFPL VPXFAYFSQA QNSCLPINGS 60 VEAITDQAKG NLKPPIDLDR QFPSDLHKAV VFRGAPWKAE IGRWLAGCHS ISNEVDIVEV 120 VVAAKMNAVV KASVIMNWDN VGAFMDTLGK DALRDCSWNA TTQHCQIDHT GDGLSQFALR 180 IVTQQKQCAS VGKARNIQID LWQSHVAFKL PSEPGAPKLT DWAKADLDNV FTTNSSKPGW 240 CNVDPAEAYA HKVKFKEECD CKYDGLWGRF CEVPAVCTCI NQCSGXGHCR GGFCQGRHFR 300 LECVNRIYDD QNSTLWTDQL YGAQMALYES ILASPHRTLN GDEADFFFVP VLDSCIITRA 360 DDGACYAPKE IWNSTMLVHW GNTNSKHKHS TTAYWADNWN EISSXKRGNH PCFDPDKDLV 420 LPAWKSPDVN SLSSKLWSRS XESRKTLFYF NGNLGPAYPN GRPEASYSMG IRQKLAEEFG 480 SSPXKEGKLG KQHAEDVIVT PLRAENYHLD LAXSIFCGVF PGDGWSGRME DSILQGCIPV 540 VIQDGIFLPY ENVLNYESFA VRISEDEIPN LINILRAFNE TEIKFRLANV QKIWQRFLYR 600 DSIMLEAERQ KTSFGRMAEW AAQFSQLIED DVFATLVQQL KKHACLXLNR FEEMITAVSE 660 ELVXEDFDRS EEMVKETEYY DVLGVSPSAT EAEIKKAYYM KARQVHPDKN PNDPLAAQNF 720 QVLGEAYQVL SDPSQRQAYD ANGKSGISTD AIIDPAAIFA MLFGSELFEE YIGQLAMASM 780 ASLDIFTEGE QFDPKKLQEK MRVVQKEREE KLAETLKNRL NQYVQGNKEE FVSHAEAEVA 840 RLSNAAYGVD MLNTIGYIYA RQSAKELGKK AIYLGVPFVA EWFRNKGHFI KSQVTAATGA 900 IALLQLQEDM KKQLSAEGNY TEEELEEYMQ SHKKLMIDSL WKLNVADIEA TLSRVCQMVL 960 QDSNAKKEEL RARAKGLKTL GRIFQRTKST GGNEGEPAQN SRVHKLNGSE SSYDTSSPIT 1020 TPKSSNLEEP SYTAFEPQVS QSPYVEAPQI AGEQLNYHFP RPTAPPGAQR HSSIGRH 1080 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
 | ||||||||
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| cd06257 | DnaJ | 7.0e-22 | 678 | 732 | 55 | + DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Hsp40 proteins are characterized by the presence of a J domain, which mediates the interaction with Hsp70. They may contain other domains as well, and the architectures provide a means of classification. | ||
| COG0484 | DnaJ | 4.0e-25 | 674 | 768 | 104 | + DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones] | ||
| pfam00226 | DnaJ | 6.0e-27 | 678 | 740 | 63 | + DnaJ domain. DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature. | ||
| pfam03016 | Exostosin | 1.0e-47 | 307 | 578 | 297 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
| pfam14308 | DnaJ-X | 3.0e-74 | 803 | 996 | 194 | + X-domain of DnaJ-containing. IN certain plant and yeast proteins, the DnaJ-1 proteins have a three-domain structure. The x-domain lies between the N-terminal DnaJ and the C-terminal Z domains. The exact function is not known. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0031072 | heat shock protein binding |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CAN80640.1 | 0 | 1 | 640 | 1 | 788 | hypothetical protein [Vitis vinifera] |
| RefSeq | NP_564134.1 | 0 | 673 | 1072 | 1 | 391 | DNAJ heat shock N-terminal domain-containing protein [Arabidopsis thaliana] |
| RefSeq | XP_002278176.1 | 0 | 673 | 1076 | 1 | 404 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002307837.1 | 0 | 673 | 1075 | 1 | 412 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002510765.1 | 0 | 673 | 1075 | 1 | 398 | Chaperone protein dnaJ, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2lo1_A | 4e-17 | 673 | 744 | 2 | 70 | A Chain A, Nmr Structure Of The Protein Bc008182, A Dnaj-Like Domain From Homo Sapiens |
| PDB | 2och_A | 9e-17 | 670 | 743 | 1 | 71 | A Chain A, J-domain Of Dnj-12 From Caenorhabditis Elegans |
| PDB | 2dn9_A | 0.000000000000006 | 678 | 749 | 8 | 78 | A Chain A, Solution Structure Of J-Domain From The Dnaj Homolog, Human Tid1 Protein |
| PDB | 2o37_A | 0.00000000000005 | 670 | 743 | 1 | 71 | A Chain A, J-Domain Of Sis1 Protein, Hsp40 Co-Chaperone From Saccharomyces Cerevisiae |
| PDB | 2lgw_A | 0.000000000001 | 679 | 748 | 4 | 74 | A Chain A, Solution Structure Of The J Domain Of Hsj1a |
