| Basic Information | |
|---|---|
| Species | Malus domestica |
| Cazyme ID | MDP0000419029 |
| Family | GT47 |
| Protein Properties | Length: 444 Molecular Weight: 51038.4 Isoelectric Point: 9.6429 |
| Chromosome | Chromosome/Scaffold: 015608118 Start: 35688 End: 38311 |
| Description | Exostosin family protein |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GT47 | 64 | 377 | 0 |
| LKVYMYDLPRRFNVGIMNRRNTDQTPVTARTWPPWPKNSGLKRQHSVEYWMMGSLLSDGNGGDGREAVRVSDPELADAFFVPFFSSLSFNTHGHNMTDPA TQIDRQLQVDLLKILGESKYWQRSGGRDHVIPMTHPNAFRFLRPQVNASIQIVVDFGRYPHVMSNLSKDVVTPYVHVVDSFTDDNRPDPFESRTTLLFFQ GRTYRKDEGIVRVKLAKVLAGYNDVHYERSVATGDNIKSSTQRMRLSKFCLHPAGDTPSSCRLFDAIVSHCVPVIVSDEIELPFEDEIDYTKFSLFFSFK EALEPDYMVNQLRN | |||
| Full Sequence |
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| Protein Sequence Length: 444 Download |
| MPNTRSHKMY GKAAFALIVA FLLLITYSIF IGTVDVRSYF LPLLPTSPPS PAAQSLCATT 60 SPPLKVYMYD LPRRFNVGIM NRRNTDQTPV TARTWPPWPK NSGLKRQHSV EYWMMGSLLS 120 DGNGGDGREA VRVSDPELAD AFFVPFFSSL SFNTHGHNMT DPATQIDRQL QVDLLKILGE 180 SKYWQRSGGR DHVIPMTHPN AFRFLRPQVN ASIQIVVDFG RYPHVMSNLS KDVVTPYVHV 240 VDSFTDDNRP DPFESRTTLL FFQGRTYRKD EGIVRVKLAK VLAGYNDVHY ERSVATGDNI 300 KSSTQRMRLS KFCLHPAGDT PSSCRLFDAI VSHCVPVIVS DEIELPFEDE IDYTKFSLFF 360 SFKEALEPDY MVNQLRNVSK ERWIEMWGTL QNISNHFEFH YPPEKEDAVN MLWRQVKNKL 420 PAVKLSVHRS RRLKIPDWWR RRK* |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03016 | Exostosin | 3.0e-67 | 62 | 367 | 314 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | AAC18793.1 | 0 | 9 | 420 | 1 | 440 | End is cut off [Arabidopsis thaliana] |
| RefSeq | NP_176908.2 | 0 | 9 | 439 | 1 | 429 | exostosin family protein [Arabidopsis thaliana] |
| RefSeq | XP_002272591.1 | 0 | 35 | 443 | 27 | 430 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002311068.1 | 0 | 63 | 439 | 1 | 380 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002512333.1 | 0 | 9 | 442 | 1 | 434 | catalytic, putative [Ricinus communis] |
