| Basic Information | |
|---|---|
| Species | Malus domestica |
| Cazyme ID | MDP0000425135 |
| Family | AA3 |
| Protein Properties | Length: 544 Molecular Weight: 59463.5 Isoelectric Point: 8.4309 |
| Chromosome | Chromosome/Scaffold: 015194198 Start: 19097 End: 21389 |
| Description | Glucose-methanol-choline (GMC) oxidoreductase family protein |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| AA3 | 53 | 542 | 0 |
| TEDYYDYIIVGGGTAGCPLAATLSSRFRVLLLERGGVAYGNRNLMTREGFLATLMDVNSFDSPTQAFTSEEGVANVRGRILGGSSAINAGFYSRADQDFY TKTSVDWDPRMVNESYEWVERAIVFRPELRTWQSAVRDGLLEAGVDPYNGFDLEHAVGTKIGGSTFDTSGRRHSAADLLKYANPLNIKVVTHASVERILL ASTMPSPASRQSAAGVVFRDRVGRYHHAVLREHGEVILSAGAIGSPQLLLLSGIGPRPYLSSWGIPVAHHLPYVGQYLYDNPRNGISIVPPFPLEHSLIQ VVGITESGAYIEAASNVIPFASPAMSVFIRTPSAPLYLTVATLMEKTIGPASAGSLRLASTNVRVNPIVRFNYFSNPVDVHRCVNGTRKIGDILKTRSME DFKFQGWFGRKDFRFVGPALPVDQSNYELMADFCRRTVSTIWHYHGGCILGKVVDGDFRVIGTDALXVVDGSTLGISPGTNPQATLMMLG | |||
| Full Sequence |
|---|
| Protein Sequence Length: 544 Download |
| MGRPISFCLL LHSAFLFVFL NAIVADARTR SSHRPHQEPS YLKFVVNATD FPTEDYYDYI 60 IVGGGTAGCP LAATLSSRFR VLLLERGGVA YGNRNLMTRE GFLATLMDVN SFDSPTQAFT 120 SEEGVANVRG RILGGSSAIN AGFYSRADQD FYTKTSVDWD PRMVNESYEW VERAIVFRPE 180 LRTWQSAVRD GLLEAGVDPY NGFDLEHAVG TKIGGSTFDT SGRRHSAADL LKYANPLNIK 240 VVTHASVERI LLASTMPSPA SRQSAAGVVF RDRVGRYHHA VLREHGEVIL SAGAIGSPQL 300 LLLSGIGPRP YLSSWGIPVA HHLPYVGQYL YDNPRNGISI VPPFPLEHSL IQVVGITESG 360 AYIEAASNVI PFASPAMSVF IRTPSAPLYL TVATLMEKTI GPASAGSLRL ASTNVRVNPI 420 VRFNYFSNPV DVHRCVNGTR KIGDILKTRS MEDFKFQGWF GRKDFRFVGP ALPVDQSNYE 480 LMADFCRRTV STIWHYHGGC ILGKVVDGDF RVIGTDALXV VDGSTLGISP GTNPQATLMM 540 LGR* |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| TIGR03970 | Rv0697 | 4.0e-36 | 58 | 542 | 532 | + dehydrogenase, Rv0697 family. This model describes a set of dehydrogenases belonging to the glucose-methanol-choline oxidoreductase (GMC oxidoreductase) family. Members of the present family are restricted to Actinobacterial genome contexts containing also members of families TIGR03962 and TIGR03969 (the mycofactocin system), and are proposed to be uniform in function. | ||
| TIGR01810 | betA | 3.0e-39 | 58 | 542 | 558 | + choline dehydrogenase. Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli , Staphylococcus xylosus , and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified [Cellular processes, Adaptations to atypical conditions]. | ||
| PRK02106 | PRK02106 | 2.0e-43 | 53 | 542 | 579 | + choline dehydrogenase; Validated | ||
| COG2303 | BetA | 7.0e-45 | 57 | 543 | 557 | + Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism] | ||
| PLN02785 | PLN02785 | 0 | 16 | 543 | 573 | + Protein HOTHEAD | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors |
| GO:0050660 | flavin adenine dinucleotide binding |
| GO:0055114 | oxidation-reduction process |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ABE65766.1 | 0 | 30 | 543 | 25 | 540 | mandelonitrile lyase [Arabidopsis thaliana] |
| GenBank | ACN31582.1 | 0 | 40 | 543 | 36 | 572 | unknown [Zea mays] |
| RefSeq | NP_177448.1 | 0 | 30 | 543 | 25 | 540 | (R)-mandelonitrile lyase, putative / (R)-oxynitrilase, putative [Arabidopsis thaliana] |
| RefSeq | XP_002277531.1 | 0 | 37 | 543 | 30 | 536 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002311915.1 | 0 | 38 | 543 | 1 | 507 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3gdp_B | 0 | 40 | 543 | 10 | 507 | A Chain A, Crystal Structure Of Class V Chitinase From Nicotiana Tobaccum |
| PDB | 3gdp_A | 0 | 40 | 543 | 10 | 507 | A Chain A, Crystal Structure Of Class V Chitinase From Nicotiana Tobaccum |
| PDB | 3gdn_B | 0 | 40 | 543 | 10 | 507 | A Chain A, Almond Hydroxynitrile Lyase In Complex With Benzaldehyde |
| PDB | 3gdn_A | 0 | 40 | 543 | 10 | 507 | A Chain A, Almond Hydroxynitrile Lyase In Complex With Benzaldehyde |
| PDB | 1ju2_B | 0 | 40 | 543 | 10 | 507 | A Chain A, Crystal Structure Of The Hydroxynitrile Lyase From Almond |
