Basic Information | |
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Species | Malus domestica |
Cazyme ID | MDP0000434271 |
Family | GT47 |
Protein Properties | Length: 684 Molecular Weight: 78470.4 Isoelectric Point: 9.9666 |
Chromosome | Chromosome/Scaffold: 020845292 Start: 1832 End: 9250 |
Description | Exostosin family protein |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 351 | 634 | 0 |
ERTLKIYIYKEGKKPIFHQPILKGLYASEGWFMKLMKGYKRFLVKDPRKAHLFYMPFSSRMLEYALYVRNSHNRTNLRQFLREYSETISAKYPYFNRTGG ADHFLVACHDWAPYETRHHMELCIKALCNADLTSGFKIGRDVSLPETYVRSARNPLRDLGGKPPSQREXLAFYAGNMHGYLRPILLEYWKDKDPDMKIFG PMPPGVASKMKYIHHMQDSKYCICPKGFEVNSPRVVEAIFYECVPVIISDNFVPPFFEVLDWGAFSLILAEKDIPKLKEILVSI |
Full Sequence |
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Protein Sequence Length: 684 Download |
MIHQRSQHQD ILCPHLHQQR IRRLKSCKPI PNNLANIYTT SLPKLTFQKL VRGIALQSLL 60 LPXGIALRSL LPHSEDTLQV KGSVLAVHSS AKSMMVRNPL TVNTSDSIDV SMFGGEIRQG 120 AEPKGNDVYK EIDLMLEEKG IDNNFESDVD RNVDDDFPSE NVVVINESLA LVSIKNRENV 180 TVLDKADETR YGFHLEKIVL PNSEITRVNA SKENSTVTAK KFDTAFPSSP LILPAVNLLE 240 NRSTSVGSTS LKRVVVASKN GLVMTRPGKK KMKSDLPLKS ITSISEMNRI LVRKRVSSDS 300 PKPRWSSVRD QEILAAKSQV ERPPIAXNDP ELYAPLFRNV SMFKRSYELM ERTLKIYIYK 360 EGKKPIFHQP ILKGLYASEG WFMKLMKGYK RFLVKDPRKA HLFYMPFSSR MLEYALYVRN 420 SHNRTNLRQF LREYSETISA KYPYFNRTGG ADHFLVACHD WAPYETRHHM ELCIKALCNA 480 DLTSGFKIGR DVSLPETYVR SARNPLRDLG GKPPSQREXL AFYAGNMHGY LRPILLEYWK 540 DKDPDMKIFG PMPPGVASKM KYIHHMQDSK YCICPKGFEV NSPRVVEAIF YECVPVIISD 600 NFVPPFFEVL DWGAFSLILA EKDIPKLKEI LVSIPEEKYL QLQLGVRKVQ KHFLWHVKPL 660 KYDLFHMTLH SIWYNRVFQI KLR* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 1.0e-61 | 350 | 634 | 305 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CAN76867.1 | 0 | 37 | 679 | 728 | 1390 | hypothetical protein [Vitis vinifera] |
EMBL | CAN76867.1 | 0 | 54 | 681 | 30 | 711 | hypothetical protein [Vitis vinifera] |
RefSeq | NP_197468.1 | 0 | 272 | 683 | 199 | 600 | exostosin family protein [Arabidopsis thaliana] |
RefSeq | XP_002283936.1 | 0 | 276 | 683 | 1 | 410 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002514248.1 | 0 | 62 | 683 | 38 | 676 | catalytic, putative [Ricinus communis] |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
EG631332 | 278 | 407 | 684 | 0 |
ES808098 | 335 | 319 | 653 | 0 |
DV712689 | 315 | 260 | 574 | 0 |
GO328935 | 276 | 284 | 559 | 0 |
EV026079 | 246 | 358 | 603 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
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