Basic Information | |
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Species | Malus domestica |
Cazyme ID | MDP0000460504 |
Family | GT47 |
Protein Properties | Length: 419 Molecular Weight: 47877.9 Isoelectric Point: 10.0576 |
Chromosome | Chromosome/Scaffold: 02367427 Start: 12075 End: 13614 |
Description | Exostosin family protein |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 78 | 369 | 0 |
TFQIYVYPTNSNKSDPPSSSASFASFAAVFLPHPNPFNPKLGNYFSEHMFKISLLSSSLVTTDPQKAHLFFLPFSVNLLRNDPRVHSESSVAEFVAKYTA AVGRDFKFWNASSGSDHFYACCHSVCREAAAKHAGLHNNAIQLTCSSSYFQRLYVTHKDVALPQVWPRPPLQSLNPPHARDKLVYFSGRIQNSNTRQQLI DLWGNDTRMDIFPGNPSYPYEEGFRRSKFCLHVRGYEVNTARVSDAIHYGCIPVIISNHYELPFANVLDWSKFSVIVNNGEVALLKKTLLSI |
Full Sequence |
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Protein Sequence Length: 419 Download |
MRTLYLSLKK MPKFKRRLLL AALLALAVSS ASWFSIFLLQ LSEQKSHNLG LSAPLPPDSG 60 PYHDWRLFAA DFREMLQTFQ IYVYPTNSNK SDPPSSSASF ASFAAVFLPH PNPFNPKLGN 120 YFSEHMFKIS LLSSSLVTTD PQKAHLFFLP FSVNLLRNDP RVHSESSVAE FVAKYTAAVG 180 RDFKFWNASS GSDHFYACCH SVCREAAAKH AGLHNNAIQL TCSSSYFQRL YVTHKDVALP 240 QVWPRPPLQS LNPPHARDKL VYFSGRIQNS NTRQQLIDLW GNDTRMDIFP GNPSYPYEEG 300 FRRSKFCLHV RGYEVNTARV SDAIHYGCIP VIISNHYELP FANVLDWSKF SVIVNNGEVA 360 LLKKTLLSIT RQSYVRLYRN LIKVRRHFVW HETPRGYDSF HMTAYQLWLK RSSLRLSA* 420 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 2.0e-47 | 121 | 369 | 267 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI29307.1 | 0 | 59 | 417 | 97 | 448 | unnamed protein product [Vitis vinifera] |
EMBL | CBI39073.1 | 0 | 63 | 416 | 108 | 445 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002265438.1 | 0 | 62 | 416 | 105 | 443 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002297901.1 | 0 | 6 | 417 | 1 | 456 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002512716.1 | 0 | 58 | 417 | 74 | 425 | catalytic, putative [Ricinus communis] |