Basic Information | |
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Species | Malus domestica |
Cazyme ID | MDP0000558976 |
Family | GT47 |
Protein Properties | Length: 510 Molecular Weight: 58276.1 Isoelectric Point: 9.8045 |
Chromosome | Chromosome/Scaffold: 002037232 Start: 19325 End: 22040 |
Description | exostosin family protein |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 119 | 429 | 0 |
LKVFMYDLPPEFHFGLLNWKPESSSVWPDLQTKIPAYPGALNLQHSIEYWLTLDLLASELPNPPNARAAIRVRNASEADIVFIPFFSSLSYNRFSKINPH EKKSKNKVLQDKLVKYVTAQKEWKRSGGRDHLIVAHHPNSLLDARMKLWPATFILSDFGRYPPNLANVEKDVIAPYKHVIKSYVNDSSTFDSRPTLLYFQ GAIYRKDGGFVRQELFYLLQGEKDVHFTFGSVKKDGXNKASQGMHTSKFCLNIAGDTPSSNRLFDAIASHCVPVIISDEIELPYEDVLDYSEFCIFVRTR DALKKNFLVNL |
Full Sequence |
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Protein Sequence Length: 510 Download |
MAERNASSLA VIARKSLFFL FIVTSTLFIF SWFFVLRSTS MPRFIDHKLL PNSKLNAVID 60 SGSSGGSENQ KDVEPSFGNR AILVDNEEEE KPSSFSQEKE ASQANNGVKC NTNEKVVLLK 120 VFMYDLPPEF HFGLLNWKPE SSSVWPDLQT KIPAYPGALN LQHSIEYWLT LDLLASELPN 180 PPNARAAIRV RNASEADIVF IPFFSSLSYN RFSKINPHEK KSKNKVLQDK LVKYVTAQKE 240 WKRSGGRDHL IVAHHPNSLL DARMKLWPAT FILSDFGRYP PNLANVEKDV IAPYKHVIKS 300 YVNDSSTFDS RPTLLYFQGA IYRKDGGFVR QELFYLLQGE KDVHFTFGSV KKDGXNKASQ 360 GMHTSKFCLN IAGDTPSSNR LFDAIASHCV PVIISDEIEL PYEDVLDYSE FCIFVRTRDA 420 LKKNFLVNLT RNXGRDEWTR MWKRLQEVQK FYEFQFPSKE GDAVQMIWQA VARRVPAIRM 480 KLHKSRRFSH SISREGKGVS RIPSPSNFW* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 7.0e-55 | 119 | 422 | 314 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | AAX33321.1 | 0 | 1 | 509 | 1 | 509 | secondary cell wall-related glycosyltransferase family 47 [Populus tremula x Populus tremuloides] |
EMBL | CAN68950.1 | 0 | 1 | 509 | 1 | 488 | hypothetical protein [Vitis vinifera] |
RefSeq | XP_002268382.1 | 0 | 1 | 509 | 1 | 488 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002319201.1 | 0 | 1 | 489 | 3 | 450 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002530948.1 | 0 | 1 | 506 | 1 | 497 | catalytic, putative [Ricinus communis] |