Basic Information | |
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Species | Malus domestica |
Cazyme ID | MDP0000630192 |
Family | GT47 |
Protein Properties | Length: 237 Molecular Weight: 26766.3 Isoelectric Point: 8.3597 |
Chromosome | Chromosome/Scaffold: 020497597 Start: 2945 End: 3655 |
Description | Exostosin family protein |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 28 | 173 | 1.8e-25 |
NXHGLPYPSYFHPSTWXEXVXWXNRVRGMDRPXLFSFIGXPRKGLEKAXARDEFLRQCGEXTRCMLLKCGSGAGKCHEPSEVLKVMSESXFCLQAPXDSF TRRSTFXSVLAXCIPVFSSXHTAYTQYKWFLLGDESTYSIYIDEKS |
Full Sequence |
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Protein Sequence Length: 237 Download |
MVLISEPTPS STYXPLMTVE RHPWKGXNXH GLPYPSYFHP STWXEXVXWX NRVRGMDRPX 60 LFSFIGXPRK GLEKAXARDE FLRQCGEXTR CMLLKCGSGA GKCHEPSEVL KVMSESXFCL 120 QAPXDSFTRR STFXSVLAXC IPVFSSXHTA YTQYKWFLLG DESTYSIYID EKSDASKRIN 180 EELLKIPKEK VTAMREKLIE LIPSLTYAXP NATNLGFGDA VDXALASLAK HVQKII* 240 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 1.0e-22 | 17 | 172 | 163 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
DDBJ | BAC42883.1 | 0 | 9 | 236 | 226 | 451 | unknown protein [Arabidopsis thaliana] |
RefSeq | NP_177014.1 | 0 | 9 | 236 | 226 | 451 | exostosin family protein [Arabidopsis thaliana] |
RefSeq | XP_002270383.1 | 0 | 16 | 233 | 286 | 500 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002300452.1 | 0 | 9 | 228 | 163 | 391 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002336132.1 | 0 | 9 | 228 | 184 | 412 | predicted protein [Populus trichocarpa] |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
CN915698 | 184 | 54 | 237 | 0 |
DK572800 | 218 | 16 | 233 | 0 |
DK572957 | 218 | 16 | 233 | 0 |
CO419064 | 179 | 37 | 212 | 0 |
EX044932 | 214 | 16 | 229 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
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