Basic Information | |
---|---|
Species | Malus domestica |
Cazyme ID | MDP0000661731 |
Family | GT47 |
Protein Properties | Length: 470 Molecular Weight: 53661.7 Isoelectric Point: 8.5248 |
Chromosome | Chromosome/Scaffold: 018849284 Start: 19430 End: 20839 |
Description | Exostosin family protein |
View CDS |
External Links |
---|
NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
---|---|---|---|
Family | Start | End | Evalue |
GT47 | 46 | 408 | 0 |
CTGRWIHIRRLPPSFNLDLLSDCSGYPLFDDFYPYLANNGLGQKTHNLSHSWYRTDPLMXELIFHRRMLEYPCLASNPQSADAVYLPYYAXIDALRYLYG PDYNSSSEQGLNLLDFLTRDDPDSWYRHMGQDHFXVLARPAMDFSQPLGNDPPXWGTSLLELPQFFNVXALTVEARAWPWQEHAVPYPTSFHPPNLSLLE MWLQRARRSRRTTLMMFAGGGGVGNNPNIRRSIRNECENNTKANNATSNNNLGRFGSGGVGYTKLCDIVDCSHGICEHDPIRFMRPMLQASFCLQPPGDT PTRRSTFDSIXAGCIPVFFEDSSAKAQYGWHLPEDQYGEFSVFIPKEDVVFKETRVLDVLRSI |
Full Sequence |
---|
Protein Sequence Length: 470 Download |
MAFKSSLLIS TFFLLFFFSI TTTTVRLCSA QIPGNNLDRP QSNSDCTGRW IHIRRLPPSF 60 NLDLLSDCSG YPLFDDFYPY LANNGLGQKT HNLSHSWYRT DPLMXELIFH RRMLEYPCLA 120 SNPQSADAVY LPYYAXIDAL RYLYGPDYNS SSEQGLNLLD FLTRDDPDSW YRHMGQDHFX 180 VLARPAMDFS QPLGNDPPXW GTSLLELPQF FNVXALTVEA RAWPWQEHAV PYPTSFHPPN 240 LSLLEMWLQR ARRSRRTTLM MFAGGGGVGN NPNIRRSIRN ECENNTKANN ATSNNNLGRF 300 GSGGVGYTKL CDIVDCSHGI CEHDPIRFMR PMLQASFCLQ PPGDTPTRRS TFDSIXAGCI 360 PVFFEDSSAK AQYGWHLPED QYGEFSVFIP KEDVVFKETR VLDVLRSIPR ARVRRMREKV 420 LEMIPRVMYR RHGSSMGLRA KKDAFDLAID GVLNKIKSKV PVQRRVFPQ* |
Functional Domains Download unfiltered results here | ||||||||
---|---|---|---|---|---|---|---|---|
Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 7.0e-46 | 46 | 408 | 371 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
---|---|
GO Term | Description |
GO:0016020 | membrane |
Annotations - NR Download unfiltered results here | |||||||
---|---|---|---|---|---|---|---|
Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
RefSeq | NP_193989.1 | 0 | 43 | 460 | 34 | 435 | exostosin family protein [Arabidopsis thaliana] |
RefSeq | XP_002267390.1 | 0 | 45 | 460 | 32 | 438 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002304426.1 | 0 | 42 | 460 | 25 | 429 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002329867.1 | 0 | 21 | 460 | 5 | 432 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002529790.1 | 0 | 12 | 460 | 7 | 449 | catalytic, putative [Ricinus communis] |