| Basic Information | |
|---|---|
| Species | Malus domestica |
| Cazyme ID | MDP0000813554 |
| Family | GT47 |
| Protein Properties | Length: 304 Molecular Weight: 34780.8 Isoelectric Point: 9.1386 |
| Chromosome | Chromosome/Scaffold: 005176460 Start: 31525 End: 32436 |
| Description | Exostosin family protein |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GT47 | 5 | 248 | 4.1e-38 |
| FKIFIYNPNSTFPFTSPSQSLFYTRLQDSHFPTENPEKAHLFFVPFPSDLPPRSVARLIRSLRSELPYWNRTLGADHFYLSCAGIGYESDRNLVELKKNS VQISCFPTPAGKFIPHKDISLPPVPSTPAPTNNTASILGYARFDWVKESTLVNQLSSDPDFLIESKPSDPNTFADRLGGSKFCLFEYKGGDVSGIGEALR FGCVPVVITDRPIQDLPFSDVLRWQEIAVFVRRSGGAVRELKRV | |||
| Full Sequence |
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| Protein Sequence Length: 304 Download |
| MFKFFKIFIY NPNSTFPFTS PSQSLFYTRL QDSHFPTENP EKAHLFFVPF PSDLPPRSVA 60 RLIRSLRSEL PYWNRTLGAD HFYLSCAGIG YESDRNLVEL KKNSVQISCF PTPAGKFIPH 120 KDISLPPVPS TPAPTNNTAS ILGYARFDWV KESTLVNQLS SDPDFLIESK PSDPNTFADR 180 LGGSKFCLFE YKGGDVSGIG EALRFGCVPV VITDRPIQDL PFSDVLRWQE IAVFVRRSGG 240 AVRELKRVLG RACWERHEKM RELGVAASRH FMWNETPEPF DAFSTLMYQL WLRRHTVRYV 300 RRE* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03016 | Exostosin | 1.0e-28 | 3 | 235 | 279 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| RefSeq | XP_001753053.1 | 0 | 20 | 302 | 161 | 462 | predicted protein [Physcomitrella patens subsp. patens] |
| RefSeq | XP_002282317.1 | 0 | 1 | 303 | 45 | 358 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002311191.1 | 0 | 1 | 303 | 40 | 343 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002316258.1 | 0 | 1 | 303 | 40 | 337 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002524235.1 | 0 | 1 | 303 | 42 | 335 | conserved hypothetical protein [Ricinus communis] |
| Hydropathy |
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| EST Download unfiltered results here | ||||
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| Hit | Length | Start | End | EValue |
| EG631217 | 303 | 1 | 303 | 0 |
| GO497463 | 207 | 1 | 207 | 0 |
| CX023964 | 174 | 95 | 268 | 0 |
| HE645575 | 305 | 1 | 303 | 0 |
| CO105146 | 260 | 46 | 299 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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| Phylogeny |
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