| Basic Information | |
|---|---|
| Species | Malus domestica |
| Cazyme ID | MDP0000878750 |
| Family | CE1 |
| Protein Properties | Length: 319 Molecular Weight: 35800.7 Isoelectric Point: 6.5012 |
| Chromosome | Chromosome/Scaffold: 005848465 Start: 12934 End: 16804 |
| Description | S-formylglutathione hydrolase |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| CE1 | 25 | 314 | 0 |
| SPTLGCSMTFHIYFPPSPSPSHRFPVLYWLSGLTCTDENFITKSGAQRVASSEGVALIALDTSPSCPFNYMFHSIPPYILCYYALIVLATCSCKLLIGGL SIEGEADSWDFGVGAGFYLNATEEKWKNWRMYDYVVKELPQLLNDNFSQLDTSRASISGHSMGGHGALTIYLKNLDKYKSVSAFAPIVNPINCPWGQKAF SNYLGGNKTDWEEYDATSLIKKFNDVSGTILIDQGEDDKFLHDQLMPHKFEEACQNAKVPLLLRLQPGYDHSYFFISTFIDDHIRHHAQA | |||
| Full Sequence |
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| Protein Sequence Length: 319 Download |
| METKPSEMSS SKMFGGYNKR YKHFSPTLGC SMTFHIYFPP SPSPSHRFPV LYWLSGLTCT 60 DENFITKSGA QRVASSEGVA LIALDTSPSC PFNYMFHSIP PYILCYYALI VLATCSCKLL 120 IGGLSIEGEA DSWDFGVGAG FYLNATEEKW KNWRMYDYVV KELPQLLNDN FSQLDTSRAS 180 ISGHSMGGHG ALTIYLKNLD KYKSVSAFAP IVNPINCPWG QKAFSNYLGG NKTDWEEYDA 240 TSLIKKFNDV SGTILIDQGE DDKFLHDQLM PHKFEEACQN AKVPLLLRLQ PGYDHSYFFI 300 STFIDDHIRH HAQALNLP* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam00756 | Esterase | 2.0e-49 | 25 | 310 | 298 | + Putative esterase. This family contains Esterase D. However it is not clear if all members of the family have the same function. This family is related to the pfam00135 family. | ||
| COG0627 | COG0627 | 1.0e-73 | 1 | 318 | 347 | + Predicted esterase [General function prediction only] | ||
| TIGR02821 | fghA_ester_D | 6.0e-122 | 8 | 315 | 309 | + S-formylglutathione hydrolase. This model describes a protein family from bacteria, yeast, and human, with a conserved critical role in formaldehyde detoxification as S-formylglutathione hydrolase (EC 3.1.2.12). Members in eukaryotes such as the human protein are better known as esterase D (EC 3.1.1.1), an enzyme with broad specificity, although S-formylglutathione hydrolase has now been demonstrated as well [Cellular processes, Detoxification]. | ||
| PLN02442 | PLN02442 | 0 | 1 | 317 | 317 | + S-formylglutathione hydrolase | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0004091 | carboxylesterase activity |
| GO:0006508 | proteolysis |
| GO:0008236 | serine-type peptidase activity |
| GO:0016023 | cytoplasmic membrane-bounded vesicle |
| GO:0018738 | S-formylglutathione hydrolase activity |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACJ11734.1 | 0 | 1 | 317 | 1 | 284 | S-formylglutathione hydrolase [Gossypium hirsutum] |
| GenBank | ACU19052.1 | 0 | 1 | 317 | 1 | 284 | unknown [Glycine max] |
| RefSeq | XP_002284489.1 | 0 | 1 | 317 | 1 | 284 | PREDICTED: hypothetical protein isoform 1 [Vitis vinifera] |
| RefSeq | XP_002284491.1 | 0 | 1 | 317 | 1 | 268 | PREDICTED: hypothetical protein isoform 2 [Vitis vinifera] |
| RefSeq | XP_002308013.1 | 0 | 1 | 303 | 1 | 270 | esterase d, s-formylglutathione hydrolase [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
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| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3fcx_B | 0 | 7 | 316 | 5 | 281 | A Chain A, Crystal Structure Of Human Esterase D |
| PDB | 3fcx_A | 0 | 7 | 316 | 5 | 281 | A Chain A, Crystal Structure Of Human Esterase D |
| PDB | 3s8y_A | 0 | 8 | 316 | 7 | 279 | A Chain A, Bromide Soaked Structure Of An Esterase From The Oil-Degrading Bacterium Oleispira Antarctica |
| PDB | 3i6y_B | 0 | 8 | 316 | 7 | 279 | A Chain A, Structure Of An Esterase From The Oil-Degrading Bacterium Oleispira Antarctica |
| PDB | 3i6y_A | 0 | 8 | 316 | 7 | 279 | A Chain A, Structure Of An Esterase From The Oil-Degrading Bacterium Oleispira Antarctica |
| Hydropathy |
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| EST Download unfiltered results here | ||||
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| Hit | Length | Start | End | EValue |
| EC982699 | 317 | 1 | 317 | 0 |
| FQ417647 | 315 | 1 | 315 | 0 |
| JG618514 | 316 | 2 | 317 | 0 |
| DT549152 | 315 | 1 | 315 | 0 |
| EE063541 | 310 | 1 | 310 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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| Phylogeny |
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