| Basic Information | |
|---|---|
| Species | Malus domestica |
| Cazyme ID | MDP0000917175 |
| Family | GH29 |
| Protein Properties | Length: 186 Molecular Weight: 20609.2 Isoelectric Point: 8.2354 |
| Chromosome | Chromosome/Scaffold: 016863146 Start: 1755 End: 2312 |
| Description | alpha-L-fucosidase 1 |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
 | |||
| Family | Start | End | Evalue |
| GH29 | 46 | 185 | 0 |
| QLQWQLGHMAMFLHFGPNTFTDSEWGTGHVDPSVFNPAKLNAAQWVRVAKDSGFSRVILTAKHHDGFCLWPTEYTNYSVSSSPWRSGGGDVVGELAAAAR DAGIALGLYLSPWDRHEPCYGKTLEYNEFYMGQMTELLTR | |||
| Full Sequence |
|---|
| Protein Sequence Length: 186 Download |
| MNKKKSTSQL TLFVFLSFSL TFSFSSSPTP RKPPPLPIXP LPSSPQLQWQ LGHMAMFLHF 60 GPNTFTDSEW GTGHVDPSVF NPAKLNAAQW VRVAKDSGFS RVILTAKHHD GFCLWPTEYT 120 NYSVSSSPWR SGGGDVVGEL AAAARDAGIA LGLYLSPWDR HEPCYGKTLE YNEFYMGQMT 180 ELLTR* |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam01120 | Alpha_L_fucos | 1.0e-15 | 80 | 185 | 117 | + Alpha-L-fucosidase. | ||
| smart00812 | Alpha_L_fucos | 8.0e-19 | 80 | 185 | 120 | + Alpha-L-fucosidase. O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in 'clans'. Family 29 encompasses alpha-L-fucosidases, which is a lysosomal enzyme responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. Deficiency of alpha-L-fucosidase results in the lysosomal storage disease fucosidosis. | ||
| COG3669 | COG3669 | 2.0e-28 | 57 | 184 | 133 | + Alpha-L-fucosidase [Carbohydrate transport and metabolism] | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0004560 | alpha-L-fucosidase activity |
| GO:0005975 | carbohydrate metabolic process |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | AAC98456.1 | 0 | 32 | 185 | 28 | 181 | unknown protein [Arabidopsis thaliana] |
| RefSeq | NP_180377.2 | 0 | 32 | 185 | 28 | 181 | ATFUC1 (alpha-L-fucosidase 1); alpha-L-fucosidase [Arabidopsis thaliana] |
| Swiss-Prot | Q8GW72 | 0 | 32 | 185 | 28 | 181 | FUCO1_ARATH RecName: Full=Alpha-L-fucosidase 1; AltName: Full=Alpha-L-fucoside fucohydrolase; AltName: Full=Alpha-1,3/4-fucosidase; Short=AtFUC1; Flags: Precursor |
| RefSeq | XP_002313533.1 | 0 | 43 | 185 | 15 | 157 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002523703.1 | 0 | 43 | 185 | 64 | 206 | alpha-l-fucosidase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3uet_B | 0 | 42 | 185 | 19 | 162 | A Chain A, Crystal Structure Of Alpha-1,34-Fucosidase From Bifidobacterium Longum Subsp. Infantis D172aE217A MUTANT COMPLEXED WITH LACTO-N- Fucopentaose Ii |
| PDB | 3uet_A | 0 | 42 | 185 | 19 | 162 | A Chain A, Crystal Structure Of Alpha-1,34-Fucosidase From Bifidobacterium Longum Subsp. Infantis D172aE217A MUTANT COMPLEXED WITH LACTO-N- Fucopentaose Ii |
| PDB | 3mo4_B | 0 | 42 | 185 | 21 | 164 | A Chain A, The Crystal Structure Of An Alpha-(1-3,4)-Fucosidase From Bifidobacterium Longum Subsp. Infantis Atcc 15697 |
| PDB | 3mo4_A | 0 | 42 | 185 | 21 | 164 | A Chain A, The Crystal Structure Of An Alpha-(1-3,4)-Fucosidase From Bifidobacterium Longum Subsp. Infantis Atcc 15697 |
| PDB | 3ues_B | 0 | 42 | 185 | 19 | 162 | A Chain A, Crystal Structure Of Alpha-1,34-Fucosidase From Bifidobacterium Longum Subsp. Infantis Complexed With Deoxyfuconojirimycin |
