y
Basic Information | |
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Species | Malus domestica |
Cazyme ID | MDP0000951395 |
Family | GT47 |
Protein Properties | Length: 509 Molecular Weight: 57436.7 Isoelectric Point: 8.2778 |
Chromosome | Chromosome/Scaffold: 020497558 Start: 4212 End: 5738 |
Description | Exostosin family protein |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 123 | 445 | 0 |
VSVYVYPLPAKFNLGLLDNCHILNVYTNMCPHVXNRGLGQPHPQLGSAASWFATHQFIAEMIFHARVENHPCRTLDPGRATLFYVPFYGGLHASSNFKEA NLTARDELTVDLVDYVQSQPWWKRHNGRDHFIALGRTAWDFMRAADGPDFGANSLLNLPAVKNMSVLTVERHPWQGSNQHGLPYPSYFHPSTWQEMVAWQ NKVREMERAHLFSFIGGPRKGLEKAAVRNEFIRQCGESTRCMLLKCGSGASKCHEPSEVLKVMSESQFCLQAPGDSFTRRSTFDSVLAGCIPVFSSPHTA YTQYKWFLPGDVSTYSVYIEEKS |
Full Sequence |
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Protein Sequence Length: 509 Download |
MFSRRQSPPS PPXTDDEKEK HYYYSNNKXT HFNNPHLRFG ALVFVFLSLW LLLLLIWFPP 60 KTTPIVELDV DLVQKPQQQQ NVHHHLIHKT QNPNRINTST TAIAAATTTT KSPFTVPTCY 120 PSVSVYVYPL PAKFNLGLLD NCHILNVYTN MCPHVXNRGL GQPHPQLGSA ASWFATHQFI 180 AEMIFHARVE NHPCRTLDPG RATLFYVPFY GGLHASSNFK EANLTARDEL TVDLVDYVQS 240 QPWWKRHNGR DHFIALGRTA WDFMRAADGP DFGANSLLNL PAVKNMSVLT VERHPWQGSN 300 QHGLPYPSYF HPSTWQEMVA WQNKVREMER AHLFSFIGGP RKGLEKAAVR NEFIRQCGES 360 TRCMLLKCGS GASKCHEPSE VLKVMSESQF CLQAPGDSFT RRSTFDSVLA GCIPVFSSPH 420 TAYTQYKWFL PGDVSTYSVY IEEKSDASKR IEEELLKIPS EKVTAMREKL IELIPSLTYA 480 HPNATNLGFG DAVDVALASL AKHIQTVI* 540 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 3.0e-61 | 121 | 458 | 349 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
DDBJ | BAC42883.1 | 0 | 109 | 503 | 50 | 446 | unknown protein [Arabidopsis thaliana] |
RefSeq | NP_177014.1 | 0 | 109 | 503 | 50 | 446 | exostosin family protein [Arabidopsis thaliana] |
RefSeq | XP_002270383.1 | 0 | 59 | 508 | 67 | 503 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002300452.1 | 0 | 119 | 505 | 1 | 397 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002336132.1 | 0 | 106 | 505 | 10 | 418 | predicted protein [Populus trichocarpa] |