Basic Information | |
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Species | Medicago truncatula |
Cazyme ID | Medtr1g093270.1 |
Family | GH47 |
Protein Properties | Length: 374 Molecular Weight: 42221.5 Isoelectric Point: 7.0836 |
Chromosome | Chromosome/Scaffold: 1 Start: 26213754 End: 26224599 |
Description | Glycosyl hydrolase family 47 protein |
View CDS |
External Links |
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NCBI Taxonomy |
Plaza |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH47 | 118 | 229 | 3.20001e-40 |
ALHSSHGQKSYPLRPELIESTYWLYKATRDPRYLDAGRDMLASLQYGTRCPCGYCHISDVEDHRQEDHMESFFLAETVKYLWLLFDLAVGPDNLVENGPY KYVFSTEGHLLP |
Full Sequence |
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Protein Sequence Length: 374 Download |
MAWGIPCTEE EHKLFLVGLQ KVERLRSHAQ KYFLRLSNFN RRCKFRAVKT DGPVRLGPKI 60 PSLDRVSVNR TTVVVPHRLT TILGANTMAV IKNKVVAKKG RHEVLMNITD GVYASLVALH 120 SSHGQKSYPL RPELIESTYW LYKATRDPRY LDAGRDMLAS LQYGTRCPCG YCHISDVEDH 180 RQEDHMESFF LAETVKYLWL LFDLAVGPDN LVENGPYKYV FSTEGHLLPA TPQISLVREH 240 CLYYGSYCRS GDLRQTYFIS EVDKDKHESN DSRFYGSWTK AKYSSDYTTS EPSAVSGLIK 300 GFCPGLNHGQ KFGLSYLLSN DEHRDYETNQ PEESTTVQSH SVMLLPAQSS DSSVPDSVSD 360 HNDSQTSESD VTS* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
cd03253 | ABCC_ATM1_transporter | 4.0e-10 | 62 | 116 | 55 | + ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C. ATM1 is an ABC transporter that is expressed in the mitochondria. Although the specific function of ATM1 is unknown, its disruption results in the accumulation of excess mitochondrial iron, loss of mitochondrial cytochromes, oxidative damage to mitochondrial DNA, and decreased levels of cytosolic heme proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. | ||
COG5265 | ATM1 | 4.0e-10 | 62 | 116 | 55 | + ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones] | ||
cd03249 | ABC_MTABC3_MDL1_MDL2 | 3.0e-11 | 63 | 117 | 55 | + ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins. MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the yeast MDL1 (multidrug resistance-like protein 1) and MDL2 (multidrug resistance-like protein 2) transporters are also included in this CD. MDL1 is an ATP-dependent permease that acts as a high-copy suppressor of ATM1 and is thought to have a role in resistance to oxidative stress. Interestingly, subfamily B is more closely related to the carboxyl-terminal component of subfamily C than the two halves of ABCC molecules are with one another. | ||
PTZ00470 | PTZ00470 | 2.0e-22 | 120 | 233 | 117 | + glycoside hydrolase family 47 protein; Provisional | ||
pfam01532 | Glyco_hydro_47 | 8.0e-39 | 126 | 229 | 106 | + Glycosyl hydrolase family 47. Members of this family are alpha-mannosidases that catalyze the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2). |
Gene Ontology | |
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GO Term | Description |
GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity |
GO:0005509 | calcium ion binding |
GO:0016020 | membrane |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI26354.1 | 0 | 115 | 342 | 389 | 617 | unnamed protein product [Vitis vinifera] |
RefSeq | NP_199184.1 | 0 | 115 | 349 | 358 | 575 | glycoside hydrolase family 47 protein [Arabidopsis thaliana] |
RefSeq | XP_002280131.1 | 0 | 115 | 365 | 356 | 630 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002311656.1 | 0 | 115 | 351 | 330 | 565 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002517026.1 | 0 | 115 | 370 | 358 | 611 | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 1x9d_A | 0.000000000000002 | 130 | 229 | 435 | 533 | A Chain A, Crystal Structure Of Human Class I Alpha-1,2-Mannosidase In Complex With Thio-Disaccharide Substrate Analogue |
PDB | 1fmi_A | 0.000000000000002 | 130 | 229 | 357 | 455 | A Chain A, Crystal Structure Of Human Class I Alpha1,2-Mannosidase |
PDB | 1fo3_A | 0.000000000000002 | 130 | 229 | 357 | 455 | A Chain A, Crystal Structure Of Human Class I Alpha1,2-Mannosidase |
PDB | 1fo2_A | 0.000000000000002 | 130 | 229 | 357 | 455 | A Chain A, Crystal Structure Of Human Class I Alpha1,2-Mannosidase In Complex With 1-Deoxymannojirimycin |
PDB | 1nxc_A | 0.000000000006 | 118 | 229 | 357 | 464 | A Chain A, Structure Of Mouse Golgi Alpha-1,2-Mannosidase Ia Reveals The Molecular Basis For Substrate Specificity Among Class I Enzymes (Family 47 Glycosidases) |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
HO801295 | 260 | 115 | 372 | 0 |
GH720347 | 216 | 96 | 304 | 0 |
HS570627 | 222 | 124 | 345 | 0 |
DV125780 | 235 | 115 | 348 | 0 |
GT655665 | 209 | 124 | 325 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
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