| Basic Information | |
|---|---|
| Species | Medicago truncatula |
| Cazyme ID | Medtr1g101760.1 |
| Family | AA3 |
| Protein Properties | Length: 464 Molecular Weight: 50943.7 Isoelectric Point: 8.7517 |
| Chromosome | Chromosome/Scaffold: 1 Start: 30111847 End: 30114128 |
| Description | Glucose-methanol-choline (GMC) oxidoreductase family protein |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| AA3 | 36 | 431 | 0 |
| EATFAPPILTYDYIVIGGGTCGCPLAATLSLLVLERGGSPYTNPEQINIHNFVNSLADTSPSSFSQQFISTDGVLNSRARVLGGGSVLNAGFYSRASYSY IRDSAVRDGLPEAGVLPYNGFAFDHLYGTKVGGTIFDKEGYRHTAADLLEYADPKKISVYLHATVQKILFKYNKKKGRPQQHISSKVKNEIIVSAGAIGS PQLLMPSGIGPANHLKEHGIQVVLDQPLVGQGMADNPMNILVVPSPLPVEVSLVETVGVTKCGSFIETVSGLSFGHSWADRLRGIFDCVKPGQHSIRSFS ITRLIFLDVRIRGPQQWVSDHSPRFTPEAMEIFADTIRSLANPILKGGVMLEKILGPKSTGHLELLTTNPNDNPSVTFNYFKDPEDLRMYVESMKT | |||
| Full Sequence |
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| Protein Sequence Length: 464 Download |
| MAWLLAQFIS TFLAGTLFFN VLSYSYRAPK HTFIKEATFA PPILTYDYIV IGGGTCGCPL 60 AATLSLLVLE RGGSPYTNPE QINIHNFVNS LADTSPSSFS QQFISTDGVL NSRARVLGGG 120 SVLNAGFYSR ASYSYIRDSA VRDGLPEAGV LPYNGFAFDH LYGTKVGGTI FDKEGYRHTA 180 ADLLEYADPK KISVYLHATV QKILFKYNKK KGRPQQHISS KVKNEIIVSA GAIGSPQLLM 240 PSGIGPANHL KEHGIQVVLD QPLVGQGMAD NPMNILVVPS PLPVEVSLVE TVGVTKCGSF 300 IETVSGLSFG HSWADRLRGI FDCVKPGQHS IRSFSITRLI FLDVRIRGPQ QWVSDHSPRF 360 TPEAMEIFAD TIRSLANPIL KGGVMLEKIL GPKSTGHLEL LTTNPNDNPS VTFNYFKDPE 420 DLRMYVESMK TIIDVINSKA FSRFRYHNMP IQALIDMMLL LPH* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| TIGR01810 | betA | 5.0e-5 | 393 | 445 | 53 | + choline dehydrogenase. Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli , Staphylococcus xylosus , and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified [Cellular processes, Adaptations to atypical conditions]. | ||
| PRK02106 | PRK02106 | 4.0e-20 | 173 | 270 | 108 | + choline dehydrogenase; Validated | ||
| TIGR01810 | betA | 2.0e-20 | 47 | 271 | 302 | + choline dehydrogenase. Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli , Staphylococcus xylosus , and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified [Cellular processes, Adaptations to atypical conditions]. | ||
| COG2303 | BetA | 3.0e-24 | 44 | 445 | 476 | + Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism] | ||
| PLN02785 | PLN02785 | 7.0e-145 | 45 | 458 | 469 | + Protein HOTHEAD | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors |
| GO:0050660 | flavin adenine dinucleotide binding |
| GO:0055114 | oxidation-reduction process |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI34759.1 | 0 | 25 | 462 | 26 | 486 | unnamed protein product [Vitis vinifera] |
| RefSeq | XP_002267807.1 | 0 | 11 | 462 | 11 | 474 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002267848.1 | 0 | 13 | 462 | 13 | 474 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002298074.1 | 0 | 1 | 462 | 1 | 484 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002510860.1 | 0 | 2 | 462 | 5 | 485 | glucose-methanol-choline (gmc) oxidoreductase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3red_L | 0 | 45 | 450 | 26 | 425 | A Chain A, 3.0 A Structure Of The Prunus Mume Hydroxynitrile Lyase Isozyme-1 |
| PDB | 3red_K | 0 | 45 | 450 | 26 | 425 | A Chain A, 3.0 A Structure Of The Prunus Mume Hydroxynitrile Lyase Isozyme-1 |
| PDB | 3red_J | 0 | 45 | 450 | 26 | 425 | A Chain A, 3.0 A Structure Of The Prunus Mume Hydroxynitrile Lyase Isozyme-1 |
| PDB | 3red_I | 0 | 45 | 450 | 26 | 425 | A Chain A, 3.0 A Structure Of The Prunus Mume Hydroxynitrile Lyase Isozyme-1 |
| PDB | 3red_H | 0 | 45 | 450 | 26 | 425 | A Chain A, 3.0 A Structure Of The Prunus Mume Hydroxynitrile Lyase Isozyme-1 |
