| Basic Information | |
|---|---|
| Species | Medicago truncatula |
| Cazyme ID | Medtr4g116070.1 |
| Family | GH79 |
| Protein Properties | Length: 530 Molecular Weight: 58090.4 Isoelectric Point: 8.9823 |
| Chromosome | Chromosome/Scaffold: 4 Start: 40197635 End: 40200785 |
| Description | glucuronidase 3 |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH79 | 53 | 523 | 0 |
| DNDFVCATLDWWPPQKCDWGRCSWGHASLLNLDLNNKILLNAIKAFSPLKIRLGGTLQDMVIYGTEDNKQSCTPFALSSKEKIDFGFTKGCLPMQRWDEL NSFFQKAGVKVIFGLNALAGRSFESGSAVGPWNYTNAESFIRYTVAKKYTIHGWEFGNELCGGGIGTSVAADQYASDVIVLRKIIQDVYRGVKPKPLIIA PGGFFDENWFKEFLNKSDESTNVVTHHIYNLGPGGDPHIVERILDPSSLNGVAGIFSSLKNVLQSSRTSAQAWVGEAGGASGSGHHLVSDAFVNSFWYLD QLGMSATYGTRTYCRQTLIGGNYGLLNTTTFMPNPDYYSALLWHRLMGGRVLSTTFYGTKKIRTYAHCAKESKGITILFLNLDNSTTVQARVALNFAKKP SPHNVGESQRREYHLTAKDGNLHSQTMVLNGNILSGNSAGDIPSLNPIYVDSSKPITVRPLSIVFAHIPDA | |||
| Full Sequence |
|---|
| Protein Sequence Length: 530 Download |
| MGYQKKLLGM FFWMYLVSFS FSFIGVNCIG LGNDSAVKGV VVIHGKAFIG RIDNDFVCAT 60 LDWWPPQKCD WGRCSWGHAS LLNLDLNNKI LLNAIKAFSP LKIRLGGTLQ DMVIYGTEDN 120 KQSCTPFALS SKEKIDFGFT KGCLPMQRWD ELNSFFQKAG VKVIFGLNAL AGRSFESGSA 180 VGPWNYTNAE SFIRYTVAKK YTIHGWEFGN ELCGGGIGTS VAADQYASDV IVLRKIIQDV 240 YRGVKPKPLI IAPGGFFDEN WFKEFLNKSD ESTNVVTHHI YNLGPGGDPH IVERILDPSS 300 LNGVAGIFSS LKNVLQSSRT SAQAWVGEAG GASGSGHHLV SDAFVNSFWY LDQLGMSATY 360 GTRTYCRQTL IGGNYGLLNT TTFMPNPDYY SALLWHRLMG GRVLSTTFYG TKKIRTYAHC 420 AKESKGITIL FLNLDNSTTV QARVALNFAK KPSPHNVGES QRREYHLTAK DGNLHSQTMV 480 LNGNILSGNS AGDIPSLNPI YVDSSKPITV RPLSIVFAHI PDAAVKACS* |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 4.0e-162 | 36 | 355 | 322 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACU20377.1 | 0 | 1 | 529 | 1 | 525 | unknown [Glycine max] |
| EMBL | CAN81917.1 | 0 | 1 | 528 | 1 | 554 | hypothetical protein [Vitis vinifera] |
| EMBL | CBI25561.1 | 0 | 8 | 528 | 1 | 532 | unnamed protein product [Vitis vinifera] |
| RefSeq | XP_002263173.1 | 0 | 1 | 528 | 5 | 558 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002533671.1 | 0 | 1 | 521 | 1 | 544 | heparanase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.00000005 | 103 | 404 | 75 | 366 | A Chain A, Pectin Methylesterase Pema From Erwinia Chrysanthemi |
| PDB | 3vnz_A | 0.00000005 | 103 | 404 | 75 | 366 | A Chain A, Pectin Methylesterase Pema From Erwinia Chrysanthemi |
| PDB | 3vny_A | 0.00000005 | 103 | 404 | 75 | 366 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
