| Basic Information | |
|---|---|
| Species | Medicago truncatula |
| Cazyme ID | Medtr5g043710.1 |
| Family | GH79 |
| Protein Properties | Length: 506 Molecular Weight: 56189.7 Isoelectric Point: 9.2596 |
| Chromosome | Chromosome/Scaffold: 5 Start: 18797338 End: 18801390 |
| Description | glucuronidase 1 |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH79 | 36 | 498 | 0 |
| DNNFICATLDWWPENKCDYNQCPWGKAGILNLDLGNRILSNAVKAFNPLRIRLGGSLQDQIIYQFGSHIKRCPNMIKIAGGLFGFSKGCLPQNRWDQVND FFNKNGVKLTFGLNALIGKNISKVDNKSFLGDWRPANAISLMKYTISKGYKIDSYELGRNELCGEGIGARVDSVQYAKDITKLRSIVNRLYPDVTTRPKV VGPAGFYDREWFDTFLHNVRPGVVDGVTHHIYNLGAGVDKELINRVQDPYFLSQIGQTFKDVAVTVRQYTPRAGAWVGEAGGAYNSGGKDVSHTFVNGFW YLDQLGMTATMNHKVYCRQTLIGGNYGLLNTTSFIPNPDYYGALLFNRLMGPKVLSISHEASHYLRTYAHCSKNGPGITVLIINMAKTIFNLSIMNDMNK QMREEYHLTPKDGNIQSDVVLLNGTPLMLTRSLDIPLLKPVLVSSSSPIKVDPQSIVFVQLKG | |||
| Full Sequence |
|---|
| Protein Sequence Length: 506 Download |
| MDVKALFYIL LLLFTISSAE DVLLNVKGVT NIATTDNNFI CATLDWWPEN KCDYNQCPWG 60 KAGILNLDLG NRILSNAVKA FNPLRIRLGG SLQDQIIYQF GSHIKRCPNM IKIAGGLFGF 120 SKGCLPQNRW DQVNDFFNKN GVKLTFGLNA LIGKNISKVD NKSFLGDWRP ANAISLMKYT 180 ISKGYKIDSY ELGRNELCGE GIGARVDSVQ YAKDITKLRS IVNRLYPDVT TRPKVVGPAG 240 FYDREWFDTF LHNVRPGVVD GVTHHIYNLG AGVDKELINR VQDPYFLSQI GQTFKDVAVT 300 VRQYTPRAGA WVGEAGGAYN SGGKDVSHTF VNGFWYLDQL GMTATMNHKV YCRQTLIGGN 360 YGLLNTTSFI PNPDYYGALL FNRLMGPKVL SISHEASHYL RTYAHCSKNG PGITVLIINM 420 AKTIFNLSIM NDMNKQMREE YHLTPKDGNI QSDVVLLNGT PLMLTRSLDI PLLKPVLVSS 480 SSPIKVDPQS IVFVQLKGFN APACV* |
| Functional Domains Download unfiltered results here | ||||||
|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description |
| pfam03662 | Glyco_hydro_79n | 3.0e-171 | 19 | 341 | 323 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI27258.1 | 0 | 1 | 505 | 3 | 524 | unnamed protein product [Vitis vinifera] |
| RefSeq | XP_002274743.1 | 0 | 1 | 505 | 1 | 522 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002315010.1 | 0 | 5 | 505 | 7 | 518 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002512114.1 | 0 | 19 | 503 | 28 | 529 | Heparanase precursor, putative [Ricinus communis] |
| RefSeq | XP_002512114.1 | 0.0000000000001 | 50 | 97 | 540 | 587 | Heparanase precursor, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.0000007 | 131 | 410 | 122 | 389 | B Chain B, Structural Basis Of Gibberellin(Ga3)-Induced Della Recognition By The Gibberellin Receptor |
| PDB | 3vnz_A | 0.0000007 | 131 | 410 | 122 | 389 | B Chain B, Structural Basis Of Gibberellin(Ga3)-Induced Della Recognition By The Gibberellin Receptor |
| PDB | 3vny_A | 0.0000007 | 131 | 410 | 122 | 389 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
