| Basic Information | |
|---|---|
| Species | Medicago truncatula |
| Cazyme ID | Medtr8g091920.1 |
| Family | GH79 |
| Protein Properties | Length: 374 Molecular Weight: 41570.6 Isoelectric Point: 9.1613 |
| Chromosome | Chromosome/Scaffold: 8 Start: 25936099 End: 25939183 |
| Description | glucuronidase 3 |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
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| Family | Start | End | Evalue |
| GH79 | 32 | 290 | 0 |
| NAESLIRYTVSKNYTIHGWELDNELCGNGVGISVGPYQYPKPLVIAPGGFFDENWFKEFLRYNDRITEKILDPAYLDGVAGITAKAWVGEAGGAHHSGHH LVSDAFFNSFWYLDQLGMSATYGTETYCRAQTDFDRKKLWFIGYNYFHNGSCQLPSIYGTKKIRTYAHCAKETVGRVVRASHTLLLLNLDNSTTVDVQVT LNYVGESQRREYHLTAKDGNLRCQTMLLNGNILSVNSAGDIPLLNPINNQLILQLTLQK | |||
| Full Sequence |
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| Protein Sequence Length: 374 Download |
| MCVPVPVPAR FKTQLFLTSL ASMVGIFQGR VNAESLIRYT VSKNYTIHGW ELDNELCGNG 60 VGISVGPYQY PKPLVIAPGG FFDENWFKEF LRYNDRITEK ILDPAYLDGV AGITAKAWVG 120 EAGGAHHSGH HLVSDAFFNS FWYLDQLGMS ATYGTETYCR AQTDFDRKKL WFIGYNYFHN 180 GSCQLPSIYG TKKIRTYAHC AKETVGRVVR ASHTLLLLNL DNSTTVDVQV TLNYVGESQR 240 REYHLTAKDG NLRCQTMLLN GNILSVNSAG DIPLLNPINN QLILQLTLQK YDKGLNALAG 300 RSLKPGSAVA QTILRNIVQE VYRDAVQKPL VIAPGGFFDA NWFKDFLRKS GKLANVVAHH 360 IYNLGPGMFH KPG* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 6.0e-20 | 314 | 367 | 55 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| pfam03662 | Glyco_hydro_79n | 1.0e-42 | 32 | 148 | 169 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
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| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
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| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACU20377.1 | 0 | 32 | 278 | 184 | 496 | unknown [Glycine max] |
| GenBank | ACU20377.1 | 2e-17 | 206 | 368 | 70 | 284 | unknown [Glycine max] |
| EMBL | CBI25561.1 | 0 | 22 | 279 | 169 | 505 | unnamed protein product [Vitis vinifera] |
| RefSeq | XP_002533671.1 | 0 | 31 | 278 | 186 | 523 | heparanase, putative [Ricinus communis] |
| RefSeq | XP_002533671.1 | 0.00000000000002 | 308 | 368 | 226 | 286 | heparanase, putative [Ricinus communis] |
| Hydropathy |
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| EST Download unfiltered results here | ||||
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| Hit | Length | Start | End | EValue |
| FK019336 | 238 | 35 | 204 | 0 |
| CA990302 | 214 | 96 | 271 | 0 |
| HO799886 | 257 | 71 | 271 | 0 |
| FK019336 | 78 | 296 | 368 | 4e-18 |
| HO799886 | 55 | 314 | 368 | 0.000000000000003 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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