| Basic Information | |
|---|---|
| Species | Panicum virgatum |
| Cazyme ID | Pavirv00008468m |
| Family | GH89 |
| Protein Properties | Length: 771 Molecular Weight: 86790.6 Isoelectric Point: 6.6289 |
| Chromosome | Chromosome/Scaffold: 003830 Start: 2109 End: 10045 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH89 | 179 | 767 | 0 |
| FNVTDRDLDDFFGGPAFLAWARMGNLHGWGGPLSQNWLDQQLALQEKILSRLIELGMVPVLPSFSGNVPAVFSKLFPSANITRLGDWNTVDADPRWCCTY LLGPSDALFIEVGQAFIKQQIKEYGDVTNIYNCDTFNENTPPTNEPAYISSLGSAIYEAMSRGNKNAMWLMQGWLFYSDAVFWKEPQMKALLHSVPIGKM IVLDLFADVKPIWKMSSQFYGVPYIWCLLHNFGGNIEMYGILDSVASGPIDAHTSYNSTMIGVGMCMEGIEQNPVVYELTSEMAFRDKKVEVEDWLKTYS YRRYGQANAEIEKAWRYLYRTIYNCTDGIADHNKDYIVEFPDISPSSFSSQLSKRRGMSIQSNHRRFFLSEVSGSLPHPHLWYSTKEAIKALELFLDAGN DFSRSLTYRYDLVDLTRQCLSKLANEVYLDAMHSYQKKDLSSLNSNTRKFLEIIVDIDVLLAADDNFLLGPWLESAKSLAVTDNERKQYEWNARTQVTMW YDNTETEQSKLHDYANKFWSGLLKSYYLPRASKYFVYLTRSLQENRSFQLEEWRKDWISYSNQWQSGKELYAVKATGDALAISRSLYRK | |||
| Full Sequence |
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| Protein Sequence Length: 771 Download |
| MGPPLPLPLL LFVLLLALLP SPPAAVAAGG PSAWGALRGA AGSRRASPAE QEAAAAGVLR 60 RLLPSHARSF SFQIDSKGSV CGESSCFRIS NVVDNLGKGG AEILIQGTTG VELVSGLHWY 120 LKYWCGAHIS WDKTGGAQLA SVPSPGSLPH VKGEGVKIER PVPWNYYQNV VTSSYSFSFN 180 VTDRDLDDFF GGPAFLAWAR MGNLHGWGGP LSQNWLDQQL ALQEKILSRL IELGMVPVLP 240 SFSGNVPAVF SKLFPSANIT RLGDWNTVDA DPRWCCTYLL GPSDALFIEV GQAFIKQQIK 300 EYGDVTNIYN CDTFNENTPP TNEPAYISSL GSAIYEAMSR GNKNAMWLMQ GWLFYSDAVF 360 WKEPQMKALL HSVPIGKMIV LDLFADVKPI WKMSSQFYGV PYIWCLLHNF GGNIEMYGIL 420 DSVASGPIDA HTSYNSTMIG VGMCMEGIEQ NPVVYELTSE MAFRDKKVEV EDWLKTYSYR 480 RYGQANAEIE KAWRYLYRTI YNCTDGIADH NKDYIVEFPD ISPSSFSSQL SKRRGMSIQS 540 NHRRFFLSEV SGSLPHPHLW YSTKEAIKAL ELFLDAGNDF SRSLTYRYDL VDLTRQCLSK 600 LANEVYLDAM HSYQKKDLSS LNSNTRKFLE IIVDIDVLLA ADDNFLLGPW LESAKSLAVT 660 DNERKQYEWN ARTQVTMWYD NTETEQSKLH DYANKFWSGL LKSYYLPRAS KYFVYLTRSL 720 QENRSFQLEE WRKDWISYSN QWQSGKELYA VKATGDALAI SRSLYRKYFS * 780 |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 7.0e-21 | 57 | 149 | 93 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 3.0e-101 | 472 | 768 | 297 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 6.0e-142 | 166 | 464 | 337 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI24942.1 | 0 | 9 | 770 | 69 | 868 | unnamed protein product [Vitis vinifera] |
| GenBank | EEC75285.1 | 0 | 46 | 769 | 51 | 811 | hypothetical protein OsI_11626 [Oryza sativa Indica Group] |
| GenBank | EEE59081.1 | 0 | 46 | 770 | 51 | 812 | hypothetical protein OsJ_10898 [Oryza sativa Japonica Group] |
| RefSeq | XP_002314048.1 | 0 | 24 | 769 | 19 | 805 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002465249.1 | 0 | 34 | 770 | 39 | 776 | hypothetical protein SORBIDRAFT_01g034960 [Sorghum bicolor] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 99 | 759 | 210 | 867 | A Chain A, Glactose Oxidase C383s Mutant Identified By Directed Evolution |
| PDB | 2vcb_A | 0 | 99 | 759 | 210 | 867 | A Chain A, Glactose Oxidase C383s Mutant Identified By Directed Evolution |
| PDB | 2vca_A | 0 | 99 | 759 | 210 | 867 | A Chain A, Glactose Oxidase C383s Mutant Identified By Directed Evolution |
| PDB | 2vc9_A | 0 | 99 | 759 | 210 | 867 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 99 | 759 | 233 | 890 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
