Basic Information | |
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Species | Panicum virgatum |
Cazyme ID | Pavirv00008589m |
Family | GH79 |
Protein Properties | Length: 569 Molecular Weight: 60761.4 Isoelectric Point: 9.0632 |
Chromosome | Chromosome/Scaffold: 004394 Start: 6263 End: 9202 |
Description | glucuronidase 3 |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 45 | 562 | 0 |
EDFVCATLDWWPPDKCDYGTCAWGRAGLLNLDLSNKVLLNAVRAFSPLKLRLGGSLQDKVLYGTADLRQPCTPFVKNESEMFGFTQGCLPLRRWDELNAF FQKSGAKIVFGLNAMKGRVPLPDGSMGGPWDYTNAASLIQYTAYKGYHIHGWELGNELSGKGVGARIGADQYAADVIALKTIVDDIHRSTPSKPLVLAPG GFFDPDWFTELIVKTKPNLLNVMTHHIYNLGPGRDTNLIEKILNPSVLDGMVSIFSNLQGILKSTGTSTVAWVGEAGGAYNSGHHLVTDAFVFSFWFLDQ LGMSAKYDTKSYCRQSLIGGNYGLLNTTTFQPNPDYYSALLWHRLMGTKVLATTFNGTNKIRAYAHCAKDSPGITLLLINLSGNTKTEVTVTAHAAAAGG AHKHGERTSYTTAQVSVTNQAATAGEHKHGARRHARKFGHAHAHAPGFAAAADGATRDEYHLTPKGGDLRSQVMLLNGKALATGADGSIPRLEAVKVDAA QPIAVAPYSIVFARISDF |
Full Sequence |
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Protein Sequence Length: 569 Download |
MAAAGLRLLG AVWLLAALLL LRPGAAASAA VAAVDGRRAI AATGEDFVCA TLDWWPPDKC 60 DYGTCAWGRA GLLNLDLSNK VLLNAVRAFS PLKLRLGGSL QDKVLYGTAD LRQPCTPFVK 120 NESEMFGFTQ GCLPLRRWDE LNAFFQKSGA KIVFGLNAMK GRVPLPDGSM GGPWDYTNAA 180 SLIQYTAYKG YHIHGWELGN ELSGKGVGAR IGADQYAADV IALKTIVDDI HRSTPSKPLV 240 LAPGGFFDPD WFTELIVKTK PNLLNVMTHH IYNLGPGRDT NLIEKILNPS VLDGMVSIFS 300 NLQGILKSTG TSTVAWVGEA GGAYNSGHHL VTDAFVFSFW FLDQLGMSAK YDTKSYCRQS 360 LIGGNYGLLN TTTFQPNPDY YSALLWHRLM GTKVLATTFN GTNKIRAYAH CAKDSPGITL 420 LLINLSGNTK TEVTVTAHAA AAGGAHKHGE RTSYTTAQVS VTNQAATAGE HKHGARRHAR 480 KFGHAHAHAP GFAAAADGAT RDEYHLTPKG GDLRSQVMLL NGKALATGAD GSIPRLEAVK 540 VDAAQPIAVA PYSIVFARIS DFHAPACS* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 0 | 43 | 346 | 304 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | ACF81144.1 | 0 | 35 | 568 | 35 | 543 | unknown [Zea mays] |
GenBank | EAY99897.1 | 0 | 7 | 568 | 5 | 525 | hypothetical protein OsI_21892 [Oryza sativa Indica Group] |
GenBank | EAZ36024.1 | 0 | 7 | 568 | 5 | 525 | hypothetical protein OsJ_20330 [Oryza sativa Japonica Group] |
RefSeq | NP_001132339.1 | 0 | 35 | 568 | 35 | 543 | hypothetical protein LOC100193781 [Zea mays] |
RefSeq | XP_002437942.1 | 0 | 1 | 568 | 1 | 554 | hypothetical protein SORBIDRAFT_10g005260 [Sorghum bicolor] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.000007 | 139 | 443 | 122 | 416 | A Chain A, Characterization And Engineering Of The Bifunctional N- And O-glucosyltransferase Involved In Xenobiotic Metabolism In Plants |
PDB | 3vnz_A | 0.000007 | 139 | 443 | 122 | 416 | A Chain A, Characterization And Engineering Of The Bifunctional N- And O-glucosyltransferase Involved In Xenobiotic Metabolism In Plants |
PDB | 3vny_A | 0.000007 | 139 | 443 | 122 | 416 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |