| Basic Information | |
|---|---|
| Species | Panicum virgatum |
| Cazyme ID | Pavirv00009032m |
| Family | GH79 |
| Protein Properties | Length: 542 Molecular Weight: 60302.8 Isoelectric Point: 8.6881 |
| Chromosome | Chromosome/Scaffold: 005155 Start: 12701 End: 16799 |
| Description | glucuronidase 2 |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH79 | 42 | 535 | 0 |
| DENYVCATIDWWPPEKCNYNQCPWGQSSILNLDLDHPFLAQAIQAFDNLRIRLGGSLQDRVVYDVGTESPCSPFRNVSNGLFGFSVGCLGMDRWDKLNDL FQKTGAIVTFGVNALYGRYNVRRSIWAGKWNSTNAYDFVKYTISKGYPVGSWEFGNELSGHGIGAKVDAKLYGKDVVEFKSILRQLYKAPLSQPLLLAPG GFFDQQWYSQLLQTSGHGVVNALTHHVYNLGGGDDVHLIRKILDPKYLDRAEDTYRDMQLTIQRHGTWASAWVSESGGVFNNGGLLVSNTFINSIWYLDQ LGMASKYNTKVFCRQTLIGGNYGLLDTQTFRPNPDYYSALLWHRLMGNGVLSIDVIAPRRLRAYAHCRRQQQGITLLLINLSNTTGYNVTLQNDINVSLG KRPNLEKGSSFTQRLRKAVSWLGSKPSSDTKKREEYHLTAKDGNLQSKTMLLNGVPLELGDDGSVPAMNPVLVVVDSPLYLAPTSIAFVVLPKF | |||
| Full Sequence |
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| Protein Sequence Length: 542 Download |
| MEVRLLLLAL ICLHAAPRWA SAQQPEEATV IVKGSTRIAE TDENYVCATI DWWPPEKCNY 60 NQCPWGQSSI LNLDLDHPFL AQAIQAFDNL RIRLGGSLQD RVVYDVGTES PCSPFRNVSN 120 GLFGFSVGCL GMDRWDKLND LFQKTGAIVT FGVNALYGRY NVRRSIWAGK WNSTNAYDFV 180 KYTISKGYPV GSWEFGNELS GHGIGAKVDA KLYGKDVVEF KSILRQLYKA PLSQPLLLAP 240 GGFFDQQWYS QLLQTSGHGV VNALTHHVYN LGGGDDVHLI RKILDPKYLD RAEDTYRDMQ 300 LTIQRHGTWA SAWVSESGGV FNNGGLLVSN TFINSIWYLD QLGMASKYNT KVFCRQTLIG 360 GNYGLLDTQT FRPNPDYYSA LLWHRLMGNG VLSIDVIAPR RLRAYAHCRR QQQGITLLLI 420 NLSNTTGYNV TLQNDINVSL GKRPNLEKGS SFTQRLRKAV SWLGSKPSSD TKKREEYHLT 480 AKDGNLQSKT MLLNGVPLEL GDDGSVPAMN PVLVVVDSPL YLAPTSIAFV VLPKFEAKAC 540 S* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 25 | 343 | 320 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACG44916.1 | 0 | 16 | 541 | 16 | 541 | heparanase-like protein 2 precursor [Zea mays] |
| GenBank | ACV84153.1 | 0 | 1 | 541 | 1 | 542 | heparanase [Oryza sativa Indica Group] |
| RefSeq | NP_001049350.1 | 0 | 1 | 541 | 1 | 541 | Os03g0211700 [Oryza sativa (japonica cultivar-group)] |
| RefSeq | NP_001145968.1 | 0 | 16 | 541 | 16 | 541 | hypothetical protein LOC100279495 [Zea mays] |
| RefSeq | XP_002468296.1 | 0 | 11 | 541 | 14 | 543 | hypothetical protein SORBIDRAFT_01g043180 [Sorghum bicolor] |
