| Basic Information | |
|---|---|
| Species | Panicum virgatum |
| Cazyme ID | Pavirv00018673m |
| Family | GH79 |
| Protein Properties | Length: 539 Molecular Weight: 58134.7 Isoelectric Point: 6.4422 |
| Chromosome | Chromosome/Scaffold: 047722 Start: 1773 End: 5804 |
| Description | glucuronidase 3 |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH79 | 49 | 532 | 0 |
| DDDFVCATLDWWPPDKCDYGTCSWGRATLLNLNLSNKILLNAVKAFSPLKLRLGGSLQDMLIYDTGDSGQPCTPFVKNTSAMFGFSQGCLPLHRWDELNA FFQKSGAKIIFGLNALNGRVPMPDGSLGGPWNYTNAASFIRYTVNKGYDIHGWELGNELSGSGVGARIDADQYAADVINLKHIIDSTYQGNPSKPLVLAP GGFFDAAWFTELVSKTRAGQMDVITHHIYNLGPGVDDHLIEKILNPSYLDGEASTFSNLQGILKSAGTSTVAWVGEAGGAYNSGHHLVTDAFVFSFWYLD QLGMSSKYDTKSYCRQTLVGGNYGLLNTTTFEPNPDYYSALLWHRLMGTTVLSATFNGTNKIRTYAHCAKNSEGITLLLINLSGNNTNSIYVTSNGAQTQ SARKEGRRFSHIPGLGEAAELTREEYHLTPKDGNLQSQQVLLNGKVLATDANGDIPKLEPMQVEGTKPITVGPYSIVFAHIPSF | |||
| Full Sequence |
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| Protein Sequence Length: 539 Download |
| MAAGLLLKVV GFCVWALFWL GGTATVSTTA LAGGDAVVVD ARSAVAATDD DFVCATLDWW 60 PPDKCDYGTC SWGRATLLNL NLSNKILLNA VKAFSPLKLR LGGSLQDMLI YDTGDSGQPC 120 TPFVKNTSAM FGFSQGCLPL HRWDELNAFF QKSGAKIIFG LNALNGRVPM PDGSLGGPWN 180 YTNAASFIRY TVNKGYDIHG WELGNELSGS GVGARIDADQ YAADVINLKH IIDSTYQGNP 240 SKPLVLAPGG FFDAAWFTEL VSKTRAGQMD VITHHIYNLG PGVDDHLIEK ILNPSYLDGE 300 ASTFSNLQGI LKSAGTSTVA WVGEAGGAYN SGHHLVTDAF VFSFWYLDQL GMSSKYDTKS 360 YCRQTLVGGN YGLLNTTTFE PNPDYYSALL WHRLMGTTVL SATFNGTNKI RTYAHCAKNS 420 EGITLLLINL SGNNTNSIYV TSNGAQTQSA RKEGRRFSHI PGLGEAAELT REEYHLTPKD 480 GNLQSQQVLL NGKVLATDAN GDIPKLEPMQ VEGTKPITVG PYSIVFAHIP SFYAPACR* 540 |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 52 | 351 | 300 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | EAY87898.1 | 0 | 1 | 538 | 1 | 541 | hypothetical protein OsI_09318 [Oryza sativa Indica Group] |
| GenBank | EAY99897.1 | 0 | 11 | 537 | 9 | 524 | hypothetical protein OsI_21892 [Oryza sativa Indica Group] |
| GenBank | EAZ36024.1 | 0 | 11 | 537 | 9 | 524 | hypothetical protein OsJ_20330 [Oryza sativa Japonica Group] |
| RefSeq | NP_001048420.1 | 0 | 1 | 538 | 1 | 541 | Os02g0802200 [Oryza sativa (japonica cultivar-group)] |
| RefSeq | XP_002452991.1 | 0 | 1 | 537 | 1 | 539 | hypothetical protein SORBIDRAFT_04g036200 [Sorghum bicolor] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.000007 | 144 | 428 | 122 | 395 | A Chain A, Solution Structure Of The C-Terminal Domain Ole E 9 |
| PDB | 3vnz_A | 0.000007 | 144 | 428 | 122 | 395 | A Chain A, Solution Structure Of The C-Terminal Domain Ole E 9 |
| PDB | 3vny_A | 0.000007 | 144 | 428 | 122 | 395 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
