| Basic Information | |
|---|---|
| Species | Panicum virgatum |
| Cazyme ID | Pavirv00030038m |
| Family | GH79 |
| Protein Properties | Length: 541 Molecular Weight: 59769.6 Isoelectric Point: 5.1661 |
| Chromosome | Chromosome/Scaffold: 006294 Start: 5182 End: 8277 |
| Description | glucuronidase 1 |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH79 | 40 | 533 | 0 |
| SDEFICATMDWWPPEKCNYDQCPWGMASVLNLDLTNPLLAKAIQAFSPLRIRVGGSLQDQVLYGTPNLGSPCDPFTKVSGSLFGFSQGCITLERWDAIND LFLNTGAVVTFGLNALQGRRQISRSVWGGPWDSSNAREFMEYTVSMNYPIDSWEFGNELSGSGIGASVGAEQYGKDLVELQTIINELYGDSRKPLVVAPG GFYDQKWFAQLLKVSGPNVLSAMTHHIYNLGAGNDPQVPNRILNPQYLSRTSDTFRSLQLTIQRHGPWSSPWVGEAGGTYNSGSRLVSNTFLNSFWYLDQ LGQSAKYDTKVYCRQSLIGGNYGLLDTDTFVPNPDYYSALLWHRLMGTGVLSTDISGSPYLRAYVHCGKQKGGVTLLLLNLHRSMGFMVSVRNDLNVNLE EGQGIRRDNVFVHGLKRTVSWVGSKASDGYSKREEYHLSGKDGDPFARTMLLNGVPLELTEDGDIPPLYPVEVSVNSPIYVAPLTIAFVVFPDF | |||
| Full Sequence |
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| Protein Sequence Length: 541 Download |
| MSLWFIFLFS LLCLAARIRS EDYSDVTVIV RGSETIASTS DEFICATMDW WPPEKCNYDQ 60 CPWGMASVLN LDLTNPLLAK AIQAFSPLRI RVGGSLQDQV LYGTPNLGSP CDPFTKVSGS 120 LFGFSQGCIT LERWDAINDL FLNTGAVVTF GLNALQGRRQ ISRSVWGGPW DSSNAREFME 180 YTVSMNYPID SWEFGNELSG SGIGASVGAE QYGKDLVELQ TIINELYGDS RKPLVVAPGG 240 FYDQKWFAQL LKVSGPNVLS AMTHHIYNLG AGNDPQVPNR ILNPQYLSRT SDTFRSLQLT 300 IQRHGPWSSP WVGEAGGTYN SGSRLVSNTF LNSFWYLDQL GQSAKYDTKV YCRQSLIGGN 360 YGLLDTDTFV PNPDYYSALL WHRLMGTGVL STDISGSPYL RAYVHCGKQK GGVTLLLLNL 420 HRSMGFMVSV RNDLNVNLEE GQGIRRDNVF VHGLKRTVSW VGSKASDGYS KREEYHLSGK 480 DGDPFARTML LNGVPLELTE DGDIPPLYPV EVSVNSPIYV APLTIAFVVF PDFEAEACGR 540 * |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 25 | 341 | 318 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACG27548.1 | 0 | 16 | 540 | 16 | 540 | heparanase-like protein 2 precursor [Zea mays] |
| GenBank | ACR34666.1 | 0 | 16 | 540 | 51 | 575 | unknown [Zea mays] |
| GenBank | EEC69565.1 | 0 | 1 | 540 | 671 | 1237 | hypothetical protein OsI_38868 [Oryza sativa Indica Group] |
| RefSeq | NP_001130921.1 | 0 | 16 | 540 | 42 | 566 | hypothetical protein LOC100192026 [Zea mays] |
| RefSeq | XP_002442385.1 | 0 | 16 | 540 | 16 | 540 | hypothetical protein SORBIDRAFT_08g019250 [Sorghum bicolor] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.002 | 128 | 419 | 115 | 397 | A Chain A, Structure And Activity Of A Flavonoid 3-O Glucosyltransferase Reveals The Basis For Plant Natural Product Modification |
| PDB | 3vnz_A | 0.002 | 128 | 419 | 115 | 397 | A Chain A, Structure And Activity Of A Flavonoid 3-O Glucosyltransferase Reveals The Basis For Plant Natural Product Modification |
| PDB | 3vny_A | 0.002 | 128 | 419 | 115 | 397 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
