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Basic Information | |
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Species | Panicum virgatum |
Cazyme ID | Pavirv00035109m |
Family | GH79 |
Protein Properties | Length: 444 Molecular Weight: 48204.3 Isoelectric Point: 6.7366 |
Chromosome | Chromosome/Scaffold: 092753 Start: 405 End: 3132 |
Description | glucuronidase 3 |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 2 | 437 | 0 |
LSNKILLNAVKAFSPLKLRLGGSLQDMLIYDTGDSGQPCTPFVKNTSAMFGFSQGCLPLHRWDELNAFFQKSGAKIIFGLNALNGRVPMPDGSLGGPWNY TNAASFIRYTVNKGYDIHGWELGNELSGSGVGARIDADQYAADVINLEHIIDSTYQGNPSKPLVLAPGGFFDAAWFNELVSKTKPGVDDHLIEKILNPSY LDGEASTFSNLQGILKSAGTSTVAWVGEAGGAYNSGHHLVTDAFVFSFWYLDQLGMSSKYDTKSYCRQTLVGGNYGLLNTTTFEPNPDYYSALLWHRLMG TTVLSTTFNGTNMIRAYAHCAKKSQGITLLLINLSGNNTNRIYVTSEGAQTQSARKEGRRFSHIPGLGEAAELTREEYHLTPKDGNLQSQQVLLNGNVLA TDANGDIPKLEPMQVEGTKPITVGPYSIVFAHIPSF |
Full Sequence |
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Protein Sequence Length: 444 Download |
NLSNKILLNA VKAFSPLKLR LGGSLQDMLI YDTGDSGQPC TPFVKNTSAM FGFSQGCLPL 60 HRWDELNAFF QKSGAKIIFG LNALNGRVPM PDGSLGGPWN YTNAASFIRY TVNKGYDIHG 120 WELGNELSGS GVGARIDADQ YAADVINLEH IIDSTYQGNP SKPLVLAPGG FFDAAWFNEL 180 VSKTKPGVDD HLIEKILNPS YLDGEASTFS NLQGILKSAG TSTVAWVGEA GGAYNSGHHL 240 VTDAFVFSFW YLDQLGMSSK YDTKSYCRQT LVGGNYGLLN TTTFEPNPDY YSALLWHRLM 300 GTTVLSTTFN GTNMIRAYAH CAKKSQGITL LLINLSGNNT NRIYVTSEGA QTQSARKEGR 360 RFSHIPGLGE AAELTREEYH LTPKDGNLQS QQVLLNGNVL ATDANGDIPK LEPMQVEGTK 420 PITVGPYSIV FAHIPSFYAP ACR* 480 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 1.0e-164 | 1 | 256 | 271 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | EAY87898.1 | 0 | 1 | 443 | 83 | 541 | hypothetical protein OsI_09318 [Oryza sativa Indica Group] |
GenBank | EAY99897.1 | 0 | 1 | 442 | 73 | 524 | hypothetical protein OsI_21892 [Oryza sativa Indica Group] |
GenBank | EAZ36024.1 | 0 | 1 | 442 | 73 | 524 | hypothetical protein OsJ_20330 [Oryza sativa Japonica Group] |
RefSeq | NP_001048420.1 | 0 | 1 | 443 | 83 | 541 | Os02g0802200 [Oryza sativa (japonica cultivar-group)] |
RefSeq | XP_002452991.1 | 0 | 5 | 442 | 87 | 539 | hypothetical protein SORBIDRAFT_04g036200 [Sorghum bicolor] |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
JG950118 | 277 | 132 | 408 | 0 |
GO873156 | 326 | 114 | 421 | 0 |
CD437707 | 271 | 2 | 256 | 0 |
JG968081 | 277 | 125 | 357 | 0 |
GO873156 | 36 | 409 | 444 | 0.0000001 |
Sequence Alignments (This image is cropped. Click for full image.) |
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