y
Basic Information | |
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Species | Panicum virgatum |
Cazyme ID | Pavirv00047509m |
Family | GT65 |
Protein Properties | Length: 512 Molecular Weight: 57890.6 Isoelectric Point: 8.3144 |
Chromosome | Chromosome/Scaffold: 015911 Start: 952 End: 3682 |
Description | O-fucosyltransferase family protein |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT65 | 147 | 456 | 0 |
GLNNQKIAFARACLTARFLNRSLLMPSLSASLFYKEVDLLQPIDFDKVFDFSKFNARCHGFVRLARYSEVLNRSEPLKLQKGSGRRWTVERDLDQLQQFI GGKADDSEVIEIVGKHPFLWPDHWPVKDYAKIFDCLVLVPEIETEVVKVISKIREAGQRARHEAGVSHSKQRRDGSTNLPIPYVAVHMRIEKDWMIHCKK WEQRSKSHEICSSKEEIIHKVSQITDLRRPVVVYLAVADSLLEDDSITSGWRVGMVAYEKKKLGVTDIYDRQPYLIKSAIDFEVCSRADVFVGNSFSTFS ILVVLSRTER |
Full Sequence |
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Protein Sequence Length: 512 Download |
SGASSASRWS HTPPLPSGAG RARRGEERLP PPGRRCDGRG VLLFLLAEPP CGSIRADSYC 60 CCFSMLRVAL EHAQGLKWVL DPWGIFSNFY FPCLLIVIVL IVLRAILSPF LAINSSEKEE 120 FFESTVPDLF PGIRRDKFVE VPQIIWGLNN QKIAFARACL TARFLNRSLL MPSLSASLFY 180 KEVDLLQPID FDKVFDFSKF NARCHGFVRL ARYSEVLNRS EPLKLQKGSG RRWTVERDLD 240 QLQQFIGGKA DDSEVIEIVG KHPFLWPDHW PVKDYAKIFD CLVLVPEIET EVVKVISKIR 300 EAGQRARHEA GVSHSKQRRD GSTNLPIPYV AVHMRIEKDW MIHCKKWEQR SKSHEICSSK 360 EEIIHKVSQI TDLRRPVVVY LAVADSLLED DSITSGWRVG MVAYEKKKLG VTDIYDRQPY 420 LIKSAIDFEV CSRADVFVGN SFSTFSILVV LSRTERLYNL GKASSCGENI GLSSYAYNVM 480 GDDGGPQRWM TDMSDTNLQR LSYGTNNVSC H* 540 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
cd11302 | O-FucT-1 | 6.0e-5 | 324 | 453 | 153 | + GDP-fucose protein O-fucosyltransferase 1. The protein O-fucosyltransferase 1 (Ofut1 or O-FucT-1) adds O-fucose to EGF (epidermal growth factor-like) repeats. The O-fucsosylation of the Notch receptor signaling protein is dependent on this enzyme, which requires GDP-fucose as a substrate. O-fucose residues added to the target of O-FucT-1 may be further elongated by other glycosyltransferases. On top of O-fucosylation, O-FucT-1 may have other functions such as the regulation of the Notch receptor exit from the ER. Six highly conserved cysteines are present in O-FucT-1, which is a soluble ER protein, as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The membrane-bound pre-protein is released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese. O-FucT-1 is similar to family 1 glycosyltransferases (GT1). | ||
cd11299 | O-FucT_plant | 4.0e-9 | 147 | 462 | 346 | + GDP-fucose protein O-fucosyltransferase, plant specific subfamily. Some members of this plant-specific family of O-fucosyltransferases have been annotated as auxin-independent growth promotors. The function of the protein seems unclear. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
cd11296 | O-FucT_like | 6.0e-23 | 297 | 456 | 164 | + GDP-fucose protein O-fucosyltransferase and related proteins. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
pfam10250 | O-FucT | 2.0e-31 | 147 | 454 | 342 | + GDP-fucose protein O-fucosyltransferase. This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese. |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | ACN28408.1 | 0 | 114 | 511 | 45 | 442 | unknown [Zea mays] |
EMBL | CAH40837.1 | 0 | 114 | 511 | 45 | 441 | protein-O-fucosyltransferase 1 [Oryza sativa] |
EMBL | CAH40838.1 | 0 | 114 | 511 | 45 | 441 | protein-O-fucosyltransferase 1 [Saccharum officinarum] |
RefSeq | NP_001147772.1 | 0 | 114 | 511 | 45 | 442 | protein-O-fucosyltransferase 1 [Zea mays] |
RefSeq | XP_002451612.1 | 0 | 114 | 511 | 45 | 442 | hypothetical protein SORBIDRAFT_04g004590 [Sorghum bicolor] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3zy6_A | 0.003 | 322 | 453 | 206 | 344 | A Chain A, Crystal Structure Of The C-Terminal Domain (Residues 83-215) Of Pf1911 Hydrogenase From Pyrococcus Furiosus, Northeast Structural Genomics Consortium Target Pfr246a |
PDB | 3zy5_A | 0.003 | 322 | 453 | 206 | 344 | A Chain A, Crystal Structure Of The C-Terminal Domain (Residues 83-215) Of Pf1911 Hydrogenase From Pyrococcus Furiosus, Northeast Structural Genomics Consortium Target Pfr246a |
PDB | 3zy4_A | 0.003 | 322 | 453 | 206 | 344 | A Chain A, Crystal Structure Of The C-Terminal Domain (Residues 83-215) Of Pf1911 Hydrogenase From Pyrococcus Furiosus, Northeast Structural Genomics Consortium Target Pfr246a |
PDB | 3zy3_B | 0.003 | 322 | 453 | 206 | 344 | A Chain A, Crystal Structure Of The C-Terminal Domain (Residues 83-215) Of Pf1911 Hydrogenase From Pyrococcus Furiosus, Northeast Structural Genomics Consortium Target Pfr246a |
PDB | 3zy3_A | 0.003 | 322 | 453 | 206 | 344 | A Chain A, Crystal Structure Of The C-Terminal Domain (Residues 83-215) Of Pf1911 Hydrogenase From Pyrococcus Furiosus, Northeast Structural Genomics Consortium Target Pfr246a |