Basic Information | |
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Species | Panicum virgatum |
Cazyme ID | Pavirv00048771m |
Family | GH79 |
Protein Properties | Length: 572 Molecular Weight: 60791.1 Isoelectric Point: 9.1818 |
Chromosome | Chromosome/Scaffold: 016466 Start: 5239 End: 8250 |
Description | glucuronidase 3 |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 44 | 565 | 0 |
EDFVCATLDWWPPDKCDYGTCAWGRAGLLNLDLSNKVLLNAVRAFSPLKLRLGGSLQDKVLYGTADLRQPCTPFAKNDSEMFGFTQGCLPLRRWDELNSF FQKSGAKIVFGLNAMNGRVQLPDGSMGGPWDYTNAASLIQYTAYKGYHIHGWELGNELSGSGVGTRIGADQYAADVITLKTIVDDIYRSNPSKSLVLAPG GFFDPAWFTELIVKTKPNLLNVITHHIYNLGPGRDTNLIEKILNPSVLDGMISIFSNLQGILKSAGTSTVAWVGEAGGAYNSGHHLVTDAFVFSFWFLDQ LGMSAKYDTKSYCRQSLIGGNYGLLNTTTFQPNPDYYSALLWHRLMGTKVLATTFNGTNKIRAYAHCARDSPGITLLLINLSGNTKTEVSVTAHAAAAAA AGAHKHVARTGYTTAQVSVTNQAAGGGGGGGEHKHGARRHGRNFGHAHTPSFAAVADGATRDEYHLTPKGGDLRSQVVLLNGKALATGADGSIPRLEAVK VDAARPIAVAPYSIVFARISHF |
Full Sequence |
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Protein Sequence Length: 572 Download |
MAAAGLRLLG AVWLSAALLL RLGAAASAAV AVVDGRRAIA ATGEDFVCAT LDWWPPDKCD 60 YGTCAWGRAG LLNLDLSNKV LLNAVRAFSP LKLRLGGSLQ DKVLYGTADL RQPCTPFAKN 120 DSEMFGFTQG CLPLRRWDEL NSFFQKSGAK IVFGLNAMNG RVQLPDGSMG GPWDYTNAAS 180 LIQYTAYKGY HIHGWELGNE LSGSGVGTRI GADQYAADVI TLKTIVDDIY RSNPSKSLVL 240 APGGFFDPAW FTELIVKTKP NLLNVITHHI YNLGPGRDTN LIEKILNPSV LDGMISIFSN 300 LQGILKSAGT STVAWVGEAG GAYNSGHHLV TDAFVFSFWF LDQLGMSAKY DTKSYCRQSL 360 IGGNYGLLNT TTFQPNPDYY SALLWHRLMG TKVLATTFNG TNKIRAYAHC ARDSPGITLL 420 LINLSGNTKT EVSVTAHAAA AAAAGAHKHV ARTGYTTAQV SVTNQAAGGG GGGGEHKHGA 480 RRHGRNFGHA HTPSFAAVAD GATRDEYHLT PKGGDLRSQV VLLNGKALAT GADGSIPRLE 540 AVKVDAARPI AVAPYSIVFA RISHFHAPAC S* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 0 | 42 | 345 | 304 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | ACF81144.1 | 0 | 34 | 571 | 35 | 543 | unknown [Zea mays] |
GenBank | EAY99897.1 | 0 | 7 | 571 | 5 | 525 | hypothetical protein OsI_21892 [Oryza sativa Indica Group] |
GenBank | EAZ36024.1 | 0 | 7 | 571 | 5 | 525 | hypothetical protein OsJ_20330 [Oryza sativa Japonica Group] |
RefSeq | NP_001132339.1 | 0 | 34 | 571 | 35 | 543 | hypothetical protein LOC100193781 [Zea mays] |
RefSeq | XP_002437942.1 | 0 | 1 | 571 | 1 | 554 | hypothetical protein SORBIDRAFT_10g005260 [Sorghum bicolor] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.0007 | 138 | 439 | 122 | 413 | A Chain A, Crystal Structure Of Medicago Truncatula Ugt71g1 Complexed With Udp-Glucose |
PDB | 3vnz_A | 0.0007 | 138 | 439 | 122 | 413 | A Chain A, Crystal Structure Of Medicago Truncatula Ugt71g1 Complexed With Udp-Glucose |
PDB | 3vny_A | 0.0007 | 138 | 439 | 122 | 413 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |