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Basic Information | |
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Species | Panicum virgatum |
Cazyme ID | Pavirv00049442m |
Family | GH31 |
Protein Properties | Length: 556 Molecular Weight: 62017 Isoelectric Point: 8.6099 |
Chromosome | Chromosome/Scaffold: 069403 Start: 3 End: 3943 |
Description | alpha-xylosidase 1 |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH31 | 269 | 556 | 0 |
FYFFAGATPLAVVDQYTSMIGRPAPMPYWAFGFHQCRWGYKNLSVVEGVVEGYRNAQIPLDVIWNDDDHMDAAKDFTLDPVNYPRPKLLAFLDKIHAQGM KYIVLIDPGIAVNNSYGVYQRGMARDIFIKLDGQPYLAQVWPGPVYFPDFLNPNGVSWWIDEVRRFHDLVPVDGLWIDMNEASNFCTGKCTIPKKHQCPI PDSKTPWVCCLDCKNLTNTRWDEPPYKINASGQTARLGFNTIATSATHYNGILEYNAHSLYGFSQAIATHKALQGLQGKRPFILTRST |
Full Sequence |
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Protein Sequence Length: 556 Download |
MLSFSHSPIV SYLLWCLVLL ALASSNGVGA TAKPKVVGSG YKLVSLVQLP NGGGLVGYLQ 60 VKQRTSTYGP DIPRLRLFVK HETRERVRVQ ITDADKPRWE VPYNLLPREP APPVTGGRVT 120 GAPFTAAEYP GEELVFTYGR DPFWFAVHRR STRQPLFNTS AGALLFKDQY LEVSTALPKD 180 AALYGLGENT QPGGIRLRPN DPYTIYTTDI SAINLNTDLY GSHPVYMDLR SLAGRGVAHA 240 VLLLNSNGMD VFYRGTSLTY KVIGGLLDFY FFAGATPLAV VDQYTSMIGR PAPMPYWAFG 300 FHQCRWGYKN LSVVEGVVEG YRNAQIPLDV IWNDDDHMDA AKDFTLDPVN YPRPKLLAFL 360 DKIHAQGMKY IVLIDPGIAV NNSYGVYQRG MARDIFIKLD GQPYLAQVWP GPVYFPDFLN 420 PNGVSWWIDE VRRFHDLVPV DGLWIDMNEA SNFCTGKCTI PKKHQCPIPD SKTPWVCCLD 480 CKNLTNTRWD EPPYKINASG QTARLGFNTI ATSATHYNGI LEYNAHSLYG FSQAIATHKA 540 LQGLQGKRPF ILTRST 600 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam01055 | Glyco_hydro_31 | 5.0e-8 | 515 | 556 | 43 | + Glycosyl hydrolases family 31. Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases. | ||
cd06602 | GH31_MGAM_SI_GAA | 9.0e-12 | 523 | 556 | 34 | + This family includes the following three closely related glycosyl hydrolase family 31 (GH31) enzymes: maltase-glucoamylase (MGAM), sucrase-isomaltase (SI), and lysosomal acid alpha-glucosidase (GAA), also known as acid-maltase. MGAM is one of the two enzymes responsible for catalyzing the last glucose-releasing step in starch digestion. SI is implicated in the digestion of dietary starch and major disaccharides such as sucrose and isomaltose, while GAA degrades glycogen in the lysosome, cleaving both alpha-1,4 and alpha-1,6 glucosidic linkages. MGAM and SI are anchored to small-intestinal brush-border epithelial cells. The absence of SI from the brush border membrane or its malfunction is associated with malabsorption disorders such as congenital sucrase-isomaltase deficiency (CSID). The domain architectures of MGAM and SI include two tandem GH31 catalytic domains, an N-terminal domain found near the membrane-bound end, and a C-terminal luminal domain. Both of the tandem GH31 domains of MGAM and SI are included in this family. The domain architecture of GAA includes an N-terminal TFF (trefoil factor family) domain in addition to the GH31 catalytic domain. Deficient GAA expression causes pompe disease, an autosomal recessive genetic disorder also known as glycogen storage disease type II (GSDII). | ||
cd06604 | GH31_glucosidase_II_MalA | 1.0e-64 | 289 | 556 | 273 | + Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized in Bacillus thermoamyloliquefaciens where it forms a homohexamer. This family also includes the MalA alpha-glucosidase from Sulfolobus sulfataricus and the AglA alpha-glucosidase from Picrophilus torridus. MalA is part of the carbohydrate-metabolizing machinery that allows this organism to utilize carbohydrates, such as maltose, as the sole carbon and energy source. | ||
pfam01055 | Glyco_hydro_31 | 2.0e-87 | 270 | 457 | 188 | + Glycosyl hydrolases family 31. Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases. | ||
cd06602 | GH31_MGAM_SI_GAA | 9.0e-92 | 289 | 453 | 169 | + This family includes the following three closely related glycosyl hydrolase family 31 (GH31) enzymes: maltase-glucoamylase (MGAM), sucrase-isomaltase (SI), and lysosomal acid alpha-glucosidase (GAA), also known as acid-maltase. MGAM is one of the two enzymes responsible for catalyzing the last glucose-releasing step in starch digestion. SI is implicated in the digestion of dietary starch and major disaccharides such as sucrose and isomaltose, while GAA degrades glycogen in the lysosome, cleaving both alpha-1,4 and alpha-1,6 glucosidic linkages. MGAM and SI are anchored to small-intestinal brush-border epithelial cells. The absence of SI from the brush border membrane or its malfunction is associated with malabsorption disorders such as congenital sucrase-isomaltase deficiency (CSID). The domain architectures of MGAM and SI include two tandem GH31 catalytic domains, an N-terminal domain found near the membrane-bound end, and a C-terminal luminal domain. Both of the tandem GH31 domains of MGAM and SI are included in this family. The domain architecture of GAA includes an N-terminal TFF (trefoil factor family) domain in addition to the GH31 catalytic domain. Deficient GAA expression causes pompe disease, an autosomal recessive genetic disorder also known as glycogen storage disease type II (GSDII). |
Gene Ontology | |
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GO Term | Description |
GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds |
GO:0005975 | carbohydrate metabolic process |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
DDBJ | BAA99366.1 | 0 | 16 | 556 | 19 | 558 | putative alpha-glucosidase [Oryza sativa Japonica Group] |
DDBJ | BAG72143.1 | 0 | 23 | 556 | 26 | 571 | alpha-glucosidase [Hordeum vulgare subsp. vulgare] |
GenBank | EEC69878.1 | 0 | 16 | 556 | 19 | 558 | hypothetical protein OsI_00249 [Oryza sativa Indica Group] |
RefSeq | NP_001041922.1 | 0 | 16 | 556 | 22 | 561 | Os01g0130400 [Oryza sativa (japonica cultivar-group)] |
RefSeq | XP_002457434.1 | 0 | 1 | 556 | 1 | 555 | hypothetical protein SORBIDRAFT_03g007230 [Sorghum bicolor] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3w38_A | 0 | 9 | 556 | 16 | 554 | A Chain A, Crystal Structure Of Human Glcat-P Apo Form |
PDB | 3w37_A | 0 | 9 | 556 | 16 | 554 | A Chain A, Crystal Structure Of Human Glcat-P Apo Form |
PDB | 3ctt_A | 0 | 52 | 556 | 62 | 528 | A Chain A, Crystal Structure Of Human Glcat-P Apo Form |
PDB | 2qmj_A | 0 | 52 | 556 | 62 | 528 | A Chain A, Crystal Structure Of Human Glcat-P Apo Form |
PDB | 2qly_A | 0 | 52 | 556 | 62 | 528 | A Chain A, Crystral Structure Of The N-Terminal Subunit Of Human Maltase- Glucoamylase |
Metabolic Pathways | |||
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Pathway Name | Reaction | EC | Protein Name |
starch degradation I | RXN-2141 | EC-3.2.1.20 | α-glucosidase |