Basic Information | |
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Species | Phaseolus vulgaris |
Cazyme ID | Phvul.002G081000.1 |
Family | GH79 |
Protein Properties | Length: 516 Molecular Weight: 57263.1 Isoelectric Point: 6.7785 |
Chromosome | Chromosome/Scaffold: 02 Start: 12219856 End: 12222638 |
Description | glucuronidase 1 |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 37 | 505 | 0 |
DENFICATIDWWPPNKCDYNQCPWGEAGILNLDLFNDILINAIKAFSPLRIRLGGSLEDQIVYQIGEEEECPVMKKKSDGLFGFGKGCLPRKRWDEVNEF LNKTGVKFTFGLNALNGKENSKEDKVKWVGDWDPTNAISLMEYSISKGYKIDSYELGNELCSGGVSAKINSVQYAKDITQLRSLVNMLYQNTSTRPKVLG PAGFYNKEWFDSFLENVGHGVVDGVTHHIYNLGPGNDKDLINKVQDPYYLSKVAQTFKDVSESVKEFTPRAGAWVGESGGAYNSGGNDVSNTFVNGFWYL DQLGMTATFNHKVYCRQALVGGNYAMLNTTNFIPNPDYYGALLWHRLMGRNVLSVSHEGSPLLRTYAHCSKKGHGITVLLINMSNSTTFRVSLVNDMNLY LDKEGGSPNQMREEYHLTPEDGNIQSQVVLLNGTPLKLTQSLEIPKMKPKLVDPSSTVKVKPDSIVFVN |
Full Sequence |
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Protein Sequence Length: 516 Download |
MEIKASICCV LLLLHSLSSA KDVNLEVKGV THIATTDENF ICATIDWWPP NKCDYNQCPW 60 GEAGILNLDL FNDILINAIK AFSPLRIRLG GSLEDQIVYQ IGEEEECPVM KKKSDGLFGF 120 GKGCLPRKRW DEVNEFLNKT GVKFTFGLNA LNGKENSKED KVKWVGDWDP TNAISLMEYS 180 ISKGYKIDSY ELGNELCSGG VSAKINSVQY AKDITQLRSL VNMLYQNTST RPKVLGPAGF 240 YNKEWFDSFL ENVGHGVVDG VTHHIYNLGP GNDKDLINKV QDPYYLSKVA QTFKDVSESV 300 KEFTPRAGAW VGESGGAYNS GGNDVSNTFV NGFWYLDQLG MTATFNHKVY CRQALVGGNY 360 AMLNTTNFIP NPDYYGALLW HRLMGRNVLS VSHEGSPLLR TYAHCSKKGH GITVLLINMS 420 NSTTFRVSLV NDMNLYLDKE GGSPNQMREE YHLTPEDGNI QSQVVLLNGT PLKLTQSLEI 480 PKMKPKLVDP SSTVKVKPDS IVFVNSRSFH APACS* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 1.0e-157 | 20 | 340 | 322 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI27258.1 | 0 | 1 | 514 | 3 | 523 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002274743.1 | 0 | 1 | 514 | 1 | 521 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002315010.1 | 0 | 3 | 515 | 11 | 518 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002512114.1 | 0 | 20 | 513 | 28 | 529 | Heparanase precursor, putative [Ricinus communis] |
RefSeq | XP_002512114.1 | 0.000000000003 | 51 | 98 | 540 | 587 | Heparanase precursor, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.00000002 | 133 | 403 | 124 | 383 | A Chain A, Crystal Structure At 1.45- Resolution Of The Major Allergen Endo-Beta-1,3-Glucanase Of Banana As A Molecular Basis For The Latex-Fruit Syndrome |
PDB | 3vnz_A | 0.00000002 | 133 | 403 | 124 | 383 | A Chain A, Crystal Structure At 1.45- Resolution Of The Major Allergen Endo-Beta-1,3-Glucanase Of Banana As A Molecular Basis For The Latex-Fruit Syndrome |
PDB | 3vny_A | 0.00000002 | 133 | 403 | 124 | 383 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |