| Basic Information | |
|---|---|
| Species | Phaseolus vulgaris |
| Cazyme ID | Phvul.005G023300.1 |
| Family | GH89 |
| Protein Properties | Length: 803 Molecular Weight: 91664.9 Isoelectric Point: 7.222 |
| Chromosome | Chromosome/Scaffold: 05 Start: 2064442 End: 2084079 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH89 | 92 | 798 | 0 |
| PEIVIRGTTAVEIASGLHWYLKYWCGAHVSWDKTGGIQTTSVPEPGSLPRLKDEGVKIKRPVPWNYYQNVVTSSYSYVWWDWERWEKEVDWMALQGVNLP LAFTGQETIWQKVFKDFNITSVDLNNFFGGPAFLAWARMGNLHGWGGPLSQNWLDQQLVLQKQIISRMLELGMTPVLPSFSGNVPAALKRIFPSAKITRL GDWNTVDSDPRWCCTYLLDASDPLFVEIGEAFIRKQIKEYGDVTDIYNCDTFNENTPPTNDPEYISTLGAAVYKGISKGDKDAVWLMQGWLFYSDSSFWK PPQIKALLHSVPLGKMVVLDLFADVKPIWKSSSQFYGTPYIWCMLHNFGGNIEMYGTLDAISSGPVDARFSANSTMVGVGMCMEGIEHNPIVYELMSEMA FRDKKVEVPEWIKSYCNRRYGKVVHEVEAAWEILYHTIYNCTDGIADHNHDFIVMFPDWDPSNSETGVSNNQKKINLLRPVNTRYLLQETPSDKPRAHLW YPSDDVIKALQLFLAGGKNLSTSLTYRYDLVDLTRQVLSKFANQLYYKAVSSFQKKNIEALQFHSNKFLQLIKDIDVLLASDDNFLLGTWLESAKKLAVN PSEIKQYEWNARTQVTMWFDTNATTQSKLHDYANKFWSGLVESYYLPRASTYFSHLLESLRQNEKFKLIEWRKQWISQSNKWQEGNELYPVKAKGDALAI SQALYEK | |||
| Full Sequence |
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| Protein Sequence Length: 803 Download |
| MLKLGFVFLI LILIPSLPVA LSKYGVMEPL LQRLDSKRAA SSVQEAAAVG LLKRLLPTHL 60 SSFEFKIVSK DVCGGDSCFL INNHKKSSQN EPEIVIRGTT AVEIASGLHW YLKYWCGAHV 120 SWDKTGGIQT TSVPEPGSLP RLKDEGVKIK RPVPWNYYQN VVTSSYSYVW WDWERWEKEV 180 DWMALQGVNL PLAFTGQETI WQKVFKDFNI TSVDLNNFFG GPAFLAWARM GNLHGWGGPL 240 SQNWLDQQLV LQKQIISRML ELGMTPVLPS FSGNVPAALK RIFPSAKITR LGDWNTVDSD 300 PRWCCTYLLD ASDPLFVEIG EAFIRKQIKE YGDVTDIYNC DTFNENTPPT NDPEYISTLG 360 AAVYKGISKG DKDAVWLMQG WLFYSDSSFW KPPQIKALLH SVPLGKMVVL DLFADVKPIW 420 KSSSQFYGTP YIWCMLHNFG GNIEMYGTLD AISSGPVDAR FSANSTMVGV GMCMEGIEHN 480 PIVYELMSEM AFRDKKVEVP EWIKSYCNRR YGKVVHEVEA AWEILYHTIY NCTDGIADHN 540 HDFIVMFPDW DPSNSETGVS NNQKKINLLR PVNTRYLLQE TPSDKPRAHL WYPSDDVIKA 600 LQLFLAGGKN LSTSLTYRYD LVDLTRQVLS KFANQLYYKA VSSFQKKNIE ALQFHSNKFL 660 QLIKDIDVLL ASDDNFLLGT WLESAKKLAV NPSEIKQYEW NARTQVTMWF DTNATTQSKL 720 HDYANKFWSG LVESYYLPRA STYFSHLLES LRQNEKFKLI EWRKQWISQS NKWQEGNELY 780 PVKAKGDALA ISQALYEKYF AK* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 9.0e-23 | 44 | 142 | 99 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 2.0e-106 | 501 | 799 | 299 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 0 | 157 | 493 | 337 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI24942.1 | 0 | 6 | 800 | 69 | 867 | unnamed protein product [Vitis vinifera] |
| GenBank | EEE59081.1 | 0 | 39 | 801 | 51 | 812 | hypothetical protein OsJ_10898 [Oryza sativa Japonica Group] |
| RefSeq | NP_196873.1 | 0 | 26 | 800 | 27 | 805 | alpha-N-acetylglucosaminidase family / NAGLU family [Arabidopsis thaliana] |
| RefSeq | XP_002273084.1 | 0 | 6 | 800 | 4 | 802 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002314048.1 | 0 | 19 | 801 | 21 | 806 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 51 | 790 | 177 | 867 | A Chain A, Crystal Structure Of A Beta-Galactosidase From Bacteroides Thetaiotaomicron |
| PDB | 2vcb_A | 0 | 51 | 790 | 177 | 867 | A Chain A, Crystal Structure Of A Beta-Galactosidase From Bacteroides Thetaiotaomicron |
| PDB | 2vca_A | 0 | 51 | 790 | 177 | 867 | A Chain A, Crystal Structure Of A Beta-Galactosidase From Bacteroides Thetaiotaomicron |
| PDB | 2vc9_A | 0 | 51 | 790 | 177 | 867 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 51 | 790 | 200 | 890 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
