| Basic Information | |
|---|---|
| Species | Phaseolus vulgaris |
| Cazyme ID | Phvul.006G131600.1 |
| Family | GT65 |
| Protein Properties | Length: 442 Molecular Weight: 50724.6 Isoelectric Point: 8.8254 |
| Chromosome | Chromosome/Scaffold: 06 Start: 24671306 End: 24672631 |
| Description | O-fucosyltransferase family protein |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GT65 | 76 | 389 | 0 |
| GLNNQKIAFARASLTARMLNRTLLMPSLSASLFYKEVDLLQPISFDKVFQFDKFNTLCNGFVRLGRYSDVSNRTEVLEMEKGSGRRWTVERDLSQLKEHG KGYLDDHEVIRIVGKNPFLWHDHWPVKDYAMIFECLDLTEEIAKEADRVVSRIRAVRRKITGNTEAVEMQNSIINDASSFQPLPYVAVHMRIEIDWMIHC KNLERRLNTNQICSSKKEIVERVRNIAGLKTPVVVYLAVADKLLNNSSILEGWEEGFLPFEKKKLGVDGIYKKYPYLIQSAIDYEVCLRADTFVGNSFST FSSLIALERTQKMI | |||
| Full Sequence |
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| Protein Sequence Length: 442 Download |
| MEVLSKFSAS TMNSVTSKCM ILLVTVLIFR ALLFPSFPGF DRIEWSNFVY IRTPFLNFDF 60 GIRQDKFLVV PQIVWGLNNQ KIAFARASLT ARMLNRTLLM PSLSASLFYK EVDLLQPISF 120 DKVFQFDKFN TLCNGFVRLG RYSDVSNRTE VLEMEKGSGR RWTVERDLSQ LKEHGKGYLD 180 DHEVIRIVGK NPFLWHDHWP VKDYAMIFEC LDLTEEIAKE ADRVVSRIRA VRRKITGNTE 240 AVEMQNSIIN DASSFQPLPY VAVHMRIEID WMIHCKNLER RLNTNQICSS KKEIVERVRN 300 IAGLKTPVVV YLAVADKLLN NSSILEGWEE GFLPFEKKKL GVDGIYKKYP YLIQSAIDYE 360 VCLRADTFVG NSFSTFSSLI ALERTQKMIR MNATNLCGEN VRWPSYAYNV LGTSNGPMRW 420 VTNMSESNLQ AISYGTNHIS C* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| cd11296 | O-FucT_like | 0.0003 | 67 | 101 | 35 | + GDP-fucose protein O-fucosyltransferase and related proteins. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
| cd11302 | O-FucT-1 | 8.0e-8 | 259 | 384 | 145 | + GDP-fucose protein O-fucosyltransferase 1. The protein O-fucosyltransferase 1 (Ofut1 or O-FucT-1) adds O-fucose to EGF (epidermal growth factor-like) repeats. The O-fucsosylation of the Notch receptor signaling protein is dependent on this enzyme, which requires GDP-fucose as a substrate. O-fucose residues added to the target of O-FucT-1 may be further elongated by other glycosyltransferases. On top of O-fucosylation, O-FucT-1 may have other functions such as the regulation of the Notch receptor exit from the ER. Six highly conserved cysteines are present in O-FucT-1, which is a soluble ER protein, as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The membrane-bound pre-protein is released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese. O-FucT-1 is similar to family 1 glycosyltransferases (GT1). | ||
| cd11299 | O-FucT_plant | 6.0e-17 | 76 | 385 | 331 | + GDP-fucose protein O-fucosyltransferase, plant specific subfamily. Some members of this plant-specific family of O-fucosyltransferases have been annotated as auxin-independent growth promotors. The function of the protein seems unclear. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
| cd11296 | O-FucT_like | 9.0e-25 | 217 | 385 | 180 | + GDP-fucose protein O-fucosyltransferase and related proteins. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
| pfam10250 | O-FucT | 8.0e-42 | 76 | 385 | 341 | + GDP-fucose protein O-fucosyltransferase. This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| RefSeq | NP_187183.3 | 0 | 14 | 441 | 16 | 442 | unknown protein [Arabidopsis thaliana] |
| RefSeq | XP_002273827.1 | 0 | 15 | 441 | 1 | 427 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002321799.1 | 0 | 93 | 441 | 1 | 347 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002332132.1 | 0 | 93 | 441 | 1 | 347 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002531235.1 | 0 | 12 | 441 | 17 | 446 | conserved hypothetical protein [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3zy6_A | 0.00003 | 259 | 384 | 212 | 344 | A Chain A, Structure And Activity Of A Flavonoid 3-O Glucosyltransferase Reveals The Basis For Plant Natural Product Modification |
| PDB | 3zy5_A | 0.00003 | 259 | 384 | 212 | 344 | A Chain A, Structure And Activity Of A Flavonoid 3-O Glucosyltransferase Reveals The Basis For Plant Natural Product Modification |
| PDB | 3zy4_A | 0.00003 | 259 | 384 | 212 | 344 | A Chain A, Structure And Activity Of A Flavonoid 3-O Glucosyltransferase Reveals The Basis For Plant Natural Product Modification |
| PDB | 3zy3_B | 0.00003 | 259 | 384 | 212 | 344 | A Chain A, Structure And Activity Of A Flavonoid 3-O Glucosyltransferase Reveals The Basis For Plant Natural Product Modification |
| PDB | 3zy3_A | 0.00003 | 259 | 384 | 212 | 344 | A Chain A, Structure And Activity Of A Flavonoid 3-O Glucosyltransferase Reveals The Basis For Plant Natural Product Modification |
