Basic Information | |
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Species | Phaseolus vulgaris |
Cazyme ID | Phvul.009G212400.1 |
Family | GH79 |
Protein Properties | Length: 537 Molecular Weight: 58668.6 Isoelectric Point: 6.6062 |
Chromosome | Chromosome/Scaffold: 09 Start: 31453794 End: 31457916 |
Description | glucuronidase 3 |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 52 | 529 | 0 |
ADFVCATLDWWPPQKCDYGKCSWGLASLLNLDLNNKIFLNAVKAFSPLKLRLGGSLQDKLTYGTDDYHQPCTPFVKKDSEMFGFTQGCLPVKRWDELHNF FEKAGAKIIFGLNALAGKSIHGGSATGPWNSTNAESFIRYNVRNGYTIYGWELGNELSGSGVGTSITADQYASDFATLRDVVYTAYKEIDSKPLVIAPGG FFDATWFREFISKSGKALDVVSHHIYNLGPGVDEHLVEKILDPSFLDMEASTFSGLKNILASTGTSATAWVGESGGAYNSGHHLVSDAFVYSFWYLDQLG MSAAYNTKTYCRQSLIGGNYGLLNTTNFLPNPDYYSALLWHRLMGRNVLSTTFSGTKMIRAYAHCAKQSKGITVLLINLDGNTSVEADVTFDNNAKSLRK MFSHSNMMELPLASETAREEYHLTPQDGNIHSQIMVLNGKPLRVNSAGDIPPLDPIYVNSSEPINVAPFSIVFAHLPH |
Full Sequence |
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Protein Sequence Length: 537 Download |
MGSRIQLLGL CLWFHFACFI FIFGSRVAVG GDATVKGTVA IDDKAVIGTT DADFVCATLD 60 WWPPQKCDYG KCSWGLASLL NLDLNNKIFL NAVKAFSPLK LRLGGSLQDK LTYGTDDYHQ 120 PCTPFVKKDS EMFGFTQGCL PVKRWDELHN FFEKAGAKII FGLNALAGKS IHGGSATGPW 180 NSTNAESFIR YNVRNGYTIY GWELGNELSG SGVGTSITAD QYASDFATLR DVVYTAYKEI 240 DSKPLVIAPG GFFDATWFRE FISKSGKALD VVSHHIYNLG PGVDEHLVEK ILDPSFLDME 300 ASTFSGLKNI LASTGTSATA WVGESGGAYN SGHHLVSDAF VYSFWYLDQL GMSAAYNTKT 360 YCRQSLIGGN YGLLNTTNFL PNPDYYSALL WHRLMGRNVL STTFSGTKMI RAYAHCAKQS 420 KGITVLLINL DGNTSVEADV TFDNNAKSLR KMFSHSNMME LPLASETARE EYHLTPQDGN 480 IHSQIMVLNG KPLRVNSAGD IPPLDPIYVN SSEPINVAPF SIVFAHLPHV VVTACG* 540 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 0 | 35 | 351 | 319 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | ACU20377.1 | 0 | 1 | 535 | 1 | 524 | unknown [Glycine max] |
EMBL | CAN81917.1 | 0 | 1 | 535 | 1 | 554 | hypothetical protein [Vitis vinifera] |
EMBL | CBI25561.1 | 0 | 8 | 535 | 1 | 532 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002263173.1 | 0 | 1 | 535 | 5 | 558 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002533671.1 | 0 | 1 | 529 | 1 | 545 | heparanase, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.000000004 | 146 | 467 | 122 | 429 | A Chain A, Polygalacturonase From Erwinia Carotovora Ssp. Carotovora |
PDB | 3vnz_A | 0.000000004 | 146 | 467 | 122 | 429 | A Chain A, Polygalacturonase From Erwinia Carotovora Ssp. Carotovora |
PDB | 3vny_A | 0.000000004 | 146 | 467 | 122 | 429 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |