y
Basic Information | |
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Species | Populus trichocarpa |
Cazyme ID | Potri.009G058100.1 |
Family | GH89 |
Protein Properties | Length: 807 Molecular Weight: 91910.1 Isoelectric Point: 7.4082 |
Chromosome | Chromosome/Scaffold: 09 Start: 6044704 End: 6056314 |
Description | alpha-N-acetylglucosaminidase family / NAGLU family |
View CDS |
External Links |
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NCBI Taxonomy |
Plaza |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH89 | 94 | 803 | 0 |
GPEISIKGTTAVEIASGLHWYLKYWCGAHVSWDKTGGVQIASIPKPGSLPHVKDKGVMIQRPVPWNYYQNVVTSSYSYVWWNWERWEKELDWMALQGINL PLAFTGQEAIWQKVFMNLNITTEDLNDFFGGPAFLAWARMGNLHGWGGPLSQNWLDQQLCLQKQILSRMLELGMTPVLPSFSGNVPAALKKIFPSANITR LGDWNTVDKNPRWCCTYLLNPSDPLFVEIGEAFIRQQVKEYGDVTDIYNCDTFNENSPPTSDPAYISSLGAAVYKAMSRGDKDAVWLMQGWLFYSDSAFW KPPQMQALLHSVPFGKMIVLDLFAEAKPIWKNSSQFYGTPYVWCLLHNFGGNIEMYGILDAISSGPVDARIIENSTMVGVGMCMEGIEHNPVVYELMSEM AFRSGKPQVLEWLKTYSRRRYGKAVRQVVAAWDILYHTIYNCTDGIADHNTDFIVKFPDWDPSLHSGSNISEQDNMRILLTSSGTRRFLFQETSSDFPEA HLWYSTQEVIQALWLFLDAGNDLAGSPTYRYDLVDLTRQVLSKLANQVYRDAMIAFRRKDARALNLHGQKFLQIIKDIDVLLASDDNFLLGTWLESAKKL AVDPNDMKLYEWNARTQVTMWYDTTKTNQSQLHDYANKFWSGLLEDYYLPRASTYFGHLMKSLEENKNFKLTEWRKEWIAFSNKWQADTKIYPVKAKGDA LAIAKALYRK |
Full Sequence |
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Protein Sequence Length: 807 Download |
MSTLKTLIFT TTLLILTLSS VALSRPEAID SLLKRLDSKR ASSSDQESAA KAVLKRLLPS 60 HIHSFLFKIV SKDVCGGHSC FLINNYYKES SGNGPEISIK GTTAVEIASG LHWYLKYWCG 120 AHVSWDKTGG VQIASIPKPG SLPHVKDKGV MIQRPVPWNY YQNVVTSSYS YVWWNWERWE 180 KELDWMALQG INLPLAFTGQ EAIWQKVFMN LNITTEDLND FFGGPAFLAW ARMGNLHGWG 240 GPLSQNWLDQ QLCLQKQILS RMLELGMTPV LPSFSGNVPA ALKKIFPSAN ITRLGDWNTV 300 DKNPRWCCTY LLNPSDPLFV EIGEAFIRQQ VKEYGDVTDI YNCDTFNENS PPTSDPAYIS 360 SLGAAVYKAM SRGDKDAVWL MQGWLFYSDS AFWKPPQMQA LLHSVPFGKM IVLDLFAEAK 420 PIWKNSSQFY GTPYVWCLLH NFGGNIEMYG ILDAISSGPV DARIIENSTM VGVGMCMEGI 480 EHNPVVYELM SEMAFRSGKP QVLEWLKTYS RRRYGKAVRQ VVAAWDILYH TIYNCTDGIA 540 DHNTDFIVKF PDWDPSLHSG SNISEQDNMR ILLTSSGTRR FLFQETSSDF PEAHLWYSTQ 600 EVIQALWLFL DAGNDLAGSP TYRYDLVDLT RQVLSKLANQ VYRDAMIAFR RKDARALNLH 660 GQKFLQIIKD IDVLLASDDN FLLGTWLESA KKLAVDPNDM KLYEWNARTQ VTMWYDTTKT 720 NQSQLHDYAN KFWSGLLEDY YLPRASTYFG HLMKSLEENK NFKLTEWRKE WIAFSNKWQA 780 DTKIYPVKAK GDALAIAKAL YRKYFG* 840 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam12971 | NAGLU_N | 1.0e-23 | 46 | 143 | 98 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
pfam12972 | NAGLU_C | 2.0e-106 | 504 | 804 | 301 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
pfam05089 | NAGLU | 0 | 160 | 499 | 340 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CAA77084.1 | 0 | 9 | 806 | 8 | 811 | alpha-N-acetylglucosaminidase [Nicotiana tabacum] |
EMBL | CBI24942.1 | 0 | 3 | 805 | 65 | 867 | unnamed protein product [Vitis vinifera] |
RefSeq | NP_196873.1 | 0 | 28 | 805 | 27 | 805 | alpha-N-acetylglucosaminidase family / NAGLU family [Arabidopsis thaliana] |
RefSeq | XP_002273084.1 | 0 | 5 | 805 | 3 | 802 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002314048.1 | 0 | 1 | 806 | 1 | 806 | predicted protein [Populus trichocarpa] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 2vcc_A | 0 | 51 | 804 | 175 | 877 | B Chain B, Crystal Structure Of Xylanase (Gh10) In Complex With Inhibitor (Xip) |
PDB | 2vcb_A | 0 | 51 | 804 | 175 | 877 | B Chain B, Crystal Structure Of Xylanase (Gh10) In Complex With Inhibitor (Xip) |
PDB | 2vca_A | 0 | 51 | 804 | 175 | 877 | B Chain B, Crystal Structure Of Xylanase (Gh10) In Complex With Inhibitor (Xip) |
PDB | 2vc9_A | 0 | 51 | 804 | 175 | 877 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
PDB | 4a4a_A | 0 | 51 | 804 | 198 | 900 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |