Basic Information | |
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Species | Populus trichocarpa |
Cazyme ID | Potri.010G160800.3 |
Family | GH79 |
Protein Properties | Length: 519 Molecular Weight: 57945.7 Isoelectric Point: 6.5813 |
Chromosome | Chromosome/Scaffold: 10 Start: 16648299 End: 16651749 |
Description | glucuronidase 1 |
View CDS |
External Links |
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NCBI Taxonomy |
Plaza |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 40 | 512 | 0 |
DDNFICATLDWWPSEKCDYNQCPWGKAGLLNLDLNNKILANAIKAFDPLRIRLGGSLQDQLVYQVGDFIKKFPHFKKQDDGLFGFSKGSLPMDRWDQLND LFKQTNAKITFGLNALIGKRKSDNSTLWVGEWNSKNARDFMKYTASKGYKIDSYELGNELCASGVSARLEADQYAKDIIQLKEIVKELYPDRETQPRVLG PAGFYDTEWFKTFLEVSGPHAVDGVTHHIYNLGVDKTLINKIQDPYFLDEIAETFKDLENVVKEFGPWAGPWVGESGGAYNSGGKDVSHTFVNGFWYLDQ LGMTATFNHKVYCRQTLIGGNYGLLNTTSFIPNPDYYGALLWHRLMGKTVLATNHFGSPYLRTYTHCSKQKPGITMLIINMSNSTSIDVSVTNDENKYPH NYRMTVNGSNQREEYHLTPKDGNIQSDVVLLNGTPLQLTSSQDIPSLSPMIVDSSSPIRVAPDSIVYVTIRDF |
Full Sequence |
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Protein Sequence Length: 519 Download |
MAGLRLAVSW ILASLCFSSL CAADDVKVFV QGVTSIAKTD DNFICATLDW WPSEKCDYNQ 60 CPWGKAGLLN LDLNNKILAN AIKAFDPLRI RLGGSLQDQL VYQVGDFIKK FPHFKKQDDG 120 LFGFSKGSLP MDRWDQLNDL FKQTNAKITF GLNALIGKRK SDNSTLWVGE WNSKNARDFM 180 KYTASKGYKI DSYELGNELC ASGVSARLEA DQYAKDIIQL KEIVKELYPD RETQPRVLGP 240 AGFYDTEWFK TFLEVSGPHA VDGVTHHIYN LGVDKTLINK IQDPYFLDEI AETFKDLENV 300 VKEFGPWAGP WVGESGGAYN SGGKDVSHTF VNGFWYLDQL GMTATFNHKV YCRQTLIGGN 360 YGLLNTTSFI PNPDYYGALL WHRLMGKTVL ATNHFGSPYL RTYTHCSKQK PGITMLIINM 420 SNSTSIDVSV TNDENKYPHN YRMTVNGSNQ REEYHLTPKD GNIQSDVVLL NGTPLQLTSS 480 QDIPSLSPMI VDSSSPIRVA PDSIVYVTIR DFKAPACA* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 0 | 23 | 341 | 321 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI27258.1 | 0 | 1 | 517 | 9 | 523 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002274743.1 | 0 | 1 | 517 | 7 | 521 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002315010.1 | 0 | 1 | 518 | 1 | 518 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002512114.1 | 0 | 23 | 516 | 28 | 529 | Heparanase precursor, putative [Ricinus communis] |
RefSeq | XP_002512114.1 | 0.00000000000004 | 53 | 101 | 539 | 587 | Heparanase precursor, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.0005 | 135 | 429 | 122 | 409 | B Chain B, Mitochondrial 2-enoyl Thioester Reductase Etr1p/etr2p Heterodimer From Candida Tropicalis |
PDB | 3vnz_A | 0.0005 | 135 | 429 | 122 | 409 | B Chain B, Mitochondrial 2-enoyl Thioester Reductase Etr1p/etr2p Heterodimer From Candida Tropicalis |
PDB | 3vny_A | 0.0005 | 135 | 429 | 122 | 409 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |