| Basic Information | |
|---|---|
| Species | Populus trichocarpa |
| Cazyme ID | Potri.010G249500.1 |
| Family | AA3 |
| Protein Properties | Length: 271 Molecular Weight: 29007 Isoelectric Point: 9.3607 |
| Chromosome | Chromosome/Scaffold: 10 Start: 22235854 End: 22237228 |
| Description | Glucose-methanol-choline (GMC) oxidoreductase family protein |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| AA3 | 1 | 232 | 4.3e-32 |
| GTTGCPLAATVSQSYRVLLLERGGVPLGKSNLMRQNGFLSTLNDILGGSSAINAGFYSRAGQAFFRESGVDRDLNVVNQSYEWVEKAIVYRPDLRNWQSA HVVGTKIGGSTFDSSGRRHSAADLLNYANAVNIQVAVYASVERILLASTSQYPRSRVSAIGVVYREMMLSAGAIGSPQLLLLSGIGPRSYLSSMGIPVAY HLPYVGQYLYDNPRNGISIVTPTPLEHSLIQV | |||
| Full Sequence |
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| Protein Sequence Length: 271 Download |
| GTTGCPLAAT VSQSYRVLLL ERGGVPLGKS NLMRQNGFLS TLNDILGGSS AINAGFYSRA 60 GQAFFRESGV DRDLNVVNQS YEWVEKAIVY RPDLRNWQSA HVVGTKIGGS TFDSSGRRHS 120 AADLLNYANA VNIQVAVYAS VERILLASTS QYPRSRVSAI GVVYREMMLS AGAIGSPQLL 180 LLSGIGPRSY LSSMGIPVAY HLPYVGQYLY DNPRNGISIV TPTPLEHSLI QVVGISEVGA 240 YLEAASTVIP FASPAQGVFI RTPSSPLIIS H 300 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| TIGR01810 | betA | 8.0e-12 | 165 | 212 | 48 | + choline dehydrogenase. Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli , Staphylococcus xylosus , and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified [Cellular processes, Adaptations to atypical conditions]. | ||
| COG2303 | BetA | 1.0e-13 | 1 | 213 | 297 | + Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism] | ||
| PRK02106 | PRK02106 | 3.0e-17 | 116 | 211 | 108 | + choline dehydrogenase; Validated | ||
| PLN02785 | PLN02785 | 3.0e-85 | 1 | 246 | 304 | + Protein HOTHEAD | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors |
| GO:0050660 | flavin adenine dinucleotide binding |
| GO:0055114 | oxidation-reduction process |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3GDN | 0 | 1 | 265 | 35 | 346 | A Chain A, Almond Hydroxynitrile Lyase In Complex With Benzaldehyde |
| GenBank | ABE65766.1 | 0 | 1 | 269 | 62 | 387 | mandelonitrile lyase [Arabidopsis thaliana] |
| RefSeq | NP_177448.1 | 0 | 1 | 269 | 62 | 387 | (R)-mandelonitrile lyase, putative / (R)-oxynitrilase, putative [Arabidopsis thaliana] |
| RefSeq | XP_002277531.1 | 0 | 1 | 270 | 58 | 384 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002311915.1 | 0 | 1 | 270 | 28 | 355 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3red_L | 0 | 1 | 267 | 35 | 351 | A Chain A, 3.0 A Structure Of The Prunus Mume Hydroxynitrile Lyase Isozyme-1 |
| PDB | 3red_K | 0 | 1 | 267 | 35 | 351 | A Chain A, 3.0 A Structure Of The Prunus Mume Hydroxynitrile Lyase Isozyme-1 |
| PDB | 3red_J | 0 | 1 | 267 | 35 | 351 | A Chain A, 3.0 A Structure Of The Prunus Mume Hydroxynitrile Lyase Isozyme-1 |
| PDB | 3red_I | 0 | 1 | 267 | 35 | 351 | A Chain A, 3.0 A Structure Of The Prunus Mume Hydroxynitrile Lyase Isozyme-1 |
| PDB | 3red_H | 0 | 1 | 267 | 35 | 351 | A Chain A, 3.0 A Structure Of The Prunus Mume Hydroxynitrile Lyase Isozyme-1 |
| Metabolic Pathways | |||
|---|---|---|---|
| Pathway Name | Reaction | EC | Protein Name |
| amygdalin and prunasin degradation | MANDELONITRILE-LYASE-RXN | EC-4.1.2.10 | (R)-mandelonitrile lyase |
| vicianin bioactivation | MANDELONITRILE-LYASE-RXN | EC-4.1.2.10 | (R)-mandelonitrile lyase |
| Hydropathy |
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| EST Download unfiltered results here | ||||
|---|---|---|---|---|
| Hit | Length | Start | End | EValue |
| CK271873 | 304 | 1 | 246 | 0 |
| DT461593 | 160 | 112 | 256 | 0 |
| HO796743 | 304 | 1 | 246 | 0 |
| EX668479 | 192 | 1 | 150 | 0 |
| CO078158 | 251 | 32 | 246 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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