Basic Information | |
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Species | Populus trichocarpa |
Cazyme ID | Potri.011G075300.1 |
Family | CBM57 |
Protein Properties | Length: 502 Molecular Weight: 55989.5 Isoelectric Point: 5.8873 |
Chromosome | Chromosome/Scaffold: 11 Start: 7242403 End: 7245831 |
Description | Leucine-rich repeat transmembrane protein kinase |
View CDS |
External Links |
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NCBI Taxonomy |
Plaza |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
CBM57 | 5 | 176 | 4.3e-24 |
HVNCGGPDVTSGSILYEGDVSIESDAAMIYSQKESNWGFSNTGDFMDDDGESPGYILRSNFSYLPMDTVYSTARRAAISLTYYGYCLENGMYTVKLDFAE IQFTDDESYRRVGKRFLDIYIQGKLEKKDFNIEEAANGSNKPYSKEFDATVTDNTLEIRLYWNGKGTTCIPK |
Full Sequence |
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Protein Sequence Length: 502 Download |
YRSFHVNCGG PDVTSGSILY EGDVSIESDA AMIYSQKESN WGFSNTGDFM DDDGESPGYI 60 LRSNFSYLPM DTVYSTARRA AISLTYYGYC LENGMYTVKL DFAEIQFTDD ESYRRVGKRF 120 LDIYIQGKLE KKDFNIEEAA NGSNKPYSKE FDATVTDNTL EIRLYWNGKG TTCIPKRGNY 180 GPLISAITVC SGILTQIVFL VMGVICWKFY FRDKFMRERD LKGLDLKTGS CTLRQLRAAT 240 NNFDSAGKIG EGGFGSVYKG KLSDGTLIAV KQLSPKSRQG NREFVNEIGM ISGLQHPNLV 300 KLYGCCIEGD QLLLVYEYME NNSLAKALFG SETSFLMLDW PTRYKICVGI ARDIKGTNVL 360 LDKDLSAKIS DFGLAKLNGE NTHISTRVAG TIGYMAPEHA LWGYLTDKAD VYSFGVVALE 420 IVSGRSNSSH RTTNEFLGLL DWAHVLQKKG NLMEIVDPKL QPAMSEVVSM LEGQTSIQEM 480 ISDPSIYGDD LHSKHLKGHY QQ |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
smart00221 | STYKc | 1.0e-39 | 248 | 471 | 262 | + Protein kinase; unclassified specificity. Phosphotransferases. The specificity of this class of kinases can not be predicted. Possible dual-specificity Ser/Thr/Tyr kinase. | ||
pfam07714 | Pkinase_Tyr | 4.0e-40 | 248 | 471 | 268 | + Protein tyrosine kinase. | ||
smart00220 | S_TKc | 2.0e-40 | 248 | 426 | 192 | + Serine/Threonine protein kinases, catalytic domain. Phosphotransferases. Serine or threonine-specific kinase subfamily. | ||
cd00180 | PKc | 1.0e-42 | 249 | 421 | 190 | + Catalytic domain of Protein Kinases. Protein Kinases (PKs), catalytic (c) domain. PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. The PK family is part of a larger superfamily that includes the catalytic domains of RIO kinases, aminoglycoside phosphotransferase, choline kinase, phosphoinositide 3-kinase (PI3K), and actin-fragmin kinase. PKs make up a large family of serine/threonine kinases, protein tyrosine kinases (PTKs), and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins. Majority of protein phosphorylation, about 95%, occurs on serine residues while only 1% occurs on tyrosine residues. Protein phosphorylation is a mechanism by which a wide variety of cellular proteins, such as enzymes and membrane channels, are reversibly regulated in response to certain stimuli. PKs often function as components of signal transduction pathways in which one kinase activates a second kinase, which in turn, may act on other kinases; this sequential action transmits a signal from the cell surface to target proteins, which results in cellular responses. The PK family is one of the largest known protein families with more than 100 homologous yeast enzymes and 550 human proteins. A fraction of PK family members are pseudokinases that lack crucial residues for catalytic activity. The mutiplicity of kinases allows for specific regulation according to substrate, tissue distribution, and cellular localization. PKs regulate many cellular processes including proliferation, division, differentiation, motility, survival, metabolism, cell-cycle progression, cytoskeletal rearrangement, immunity, and neuronal functions. Many kinases are implicated in the development of various human diseases including different types of cancer. | ||
pfam11721 | Malectin | 1.0e-53 | 3 | 187 | 188 | + Di-glucose binding within endoplasmic reticulum. Malectin is a membrane-anchored protein of the endoplasmic reticulum that recognises and binds Glc2-N-glycan. It carries a signal peptide from residues 1-26, a C-terminal transmembrane helix from residues 255-274, and a highly conserved central part of approximately 190 residues followed by an acidic, glutamate-rich region. Carbohydrate-binding is mediated by the four aromatic residues, Y67, Y89, Y116, and F117 and the aspartate at D186. NMR-based ligand-screening studies has shown binding of the protein to maltose and related oligosaccharides, on the basis of which the protein has been designated "malectin", and its endogenous ligand is found to be Glc2-high-mannose N-glycan. |
Gene Ontology | |
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GO Term | Description |
GO:0004672 | protein kinase activity |
GO:0005524 | ATP binding |
GO:0006468 | protein phosphorylation |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
RefSeq | XP_002317319.1 | 0 | 1 | 502 | 352 | 926 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002317383.1 | 0 | 1 | 502 | 280 | 859 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002332248.1 | 0 | 1 | 502 | 293 | 865 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002332683.1 | 0 | 1 | 502 | 18 | 592 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002332687.1 | 0 | 1 | 502 | 13 | 577 | predicted protein [Populus trichocarpa] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 2qkw_B | 0 | 233 | 460 | 31 | 273 | A Chain A, Structural Basis For Activation Of Plant Immunity By Bacterial Effector Protein Avrpto |
PDB | 3hgk_D | 0 | 233 | 460 | 31 | 273 | E Chain E, Crystal Structure Of Effect Protein Avrptob Complexed With Kinase Pto |
PDB | 3hgk_C | 0 | 233 | 460 | 31 | 273 | E Chain E, Crystal Structure Of Effect Protein Avrptob Complexed With Kinase Pto |
PDB | 3hgk_B | 0 | 233 | 460 | 31 | 273 | E Chain E, Crystal Structure Of Effect Protein Avrptob Complexed With Kinase Pto |
PDB | 3hgk_A | 0 | 233 | 460 | 31 | 273 | E Chain E, Crystal Structure Of Effect Protein Avrptob Complexed With Kinase Pto |