| Basic Information | |
|---|---|
| Species | Populus trichocarpa |
| Cazyme ID | Potri.015G049100.4 |
| Family | GH79 |
| Protein Properties | Length: 540 Molecular Weight: 59846 Isoelectric Point: 7.1746 |
| Chromosome | Chromosome/Scaffold: 15 Start: 5225569 End: 5231168 |
| Description | glucuronidase 2 |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH79 | 39 | 533 | 0 |
| DDNFICATLDWWPHDKCNYNQCPWSYSSVTNLDLSHPLLAKAIQAFRNLRIRIGGSLQDQVLYDVESLKAPCHPFRKMKGGLFGFSKGCLHMNRWDELNH LFSRTGAIVTFGLNALYGRHQIRKGVWGGAWDSSNACDFMNYTVLKGYKIDSWEYGNELSGSGVSASVSAELYGKDLIKLKDVVNNLYKNSDLKPSLVAP GGFFDKQWYAKLLQVTGSGIVNFVTHHIYNLGAGMDPNLVNKILDPHYLSKVSETFSNLSQTIQQNGPWASAWVGESGGAYNSGGRHVSDTFVNSFWYLD QLGMASRYNTKVYCRQTLVGGHYGLLNTTTLVPNPDYYSALLWHRLMGKGVLAVGSNASPFLRSYAHCSKGRAGITLLLINLSNQTDFIISVQNSMDMRL TVEENISGENSFVRGLKRSVSWVGSRASDEPLYREEYHLTAKDGNLQSRTMVLNGIPLELTEDENIPSLDPVRLDVNSPLYINPLSISFIVFPNF | |||
| Full Sequence |
|---|
| Protein Sequence Length: 540 Download |
| MEFSFSLLLF LASFPVILAQ EGTRATISID GTIAVAVIDD NFICATLDWW PHDKCNYNQC 60 PWSYSSVTNL DLSHPLLAKA IQAFRNLRIR IGGSLQDQVL YDVESLKAPC HPFRKMKGGL 120 FGFSKGCLHM NRWDELNHLF SRTGAIVTFG LNALYGRHQI RKGVWGGAWD SSNACDFMNY 180 TVLKGYKIDS WEYGNELSGS GVSASVSAEL YGKDLIKLKD VVNNLYKNSD LKPSLVAPGG 240 FFDKQWYAKL LQVTGSGIVN FVTHHIYNLG AGMDPNLVNK ILDPHYLSKV SETFSNLSQT 300 IQQNGPWASA WVGESGGAYN SGGRHVSDTF VNSFWYLDQL GMASRYNTKV YCRQTLVGGH 360 YGLLNTTTLV PNPDYYSALL WHRLMGKGVL AVGSNASPFL RSYAHCSKGR AGITLLLINL 420 SNQTDFIISV QNSMDMRLTV EENISGENSF VRGLKRSVSW VGSRASDEPL YREEYHLTAK 480 DGNLQSRTMV LNGIPLELTE DENIPSLDPV RLDVNSPLYI NPLSISFIVF PNFDAPACA* 540 |
| Functional Domains Download unfiltered results here | ||||||
|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description |
| pfam03662 | Glyco_hydro_79n | 0 | 22 | 341 | 320 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CAB62595.1 | 0 | 18 | 539 | 1 | 521 | putative protein [Arabidopsis thaliana] |
| EMBL | CBI15157.1 | 0 | 12 | 539 | 12 | 513 | unnamed protein product [Vitis vinifera] |
| RefSeq | XP_002284470.1 | 0 | 12 | 539 | 12 | 539 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002321464.1 | 0 | 1 | 539 | 1 | 541 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002514696.1 | 0 | 15 | 539 | 15 | 539 | Heparanase-2, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.0002 | 259 | 429 | 235 | 409 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
| PDB | 3vnz_A | 0.0002 | 259 | 429 | 235 | 409 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
| PDB | 3vny_A | 0.0002 | 259 | 429 | 235 | 409 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
