y
Basic Information | |
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Species | Populus trichocarpa |
Cazyme ID | Potri.018G024200.1 |
Family | GH79 |
Protein Properties | Length: 564 Molecular Weight: 61197 Isoelectric Point: 6.4388 |
Chromosome | Chromosome/Scaffold: 18 Start: 1938402 End: 1942647 |
Description | glucuronidase 3 |
View CDS |
External Links |
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NCBI Taxonomy |
Plaza |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 70 | 553 | 0 |
DHDFICATLDWWPPDKCDYGTCSWGKASFLNLDLTNPILLNAIKAFSPLKIRMGGTLQDKVTYERLGEPCPTFVKSSPEMFGFSQGCLPMSRWDELNNFF KQAGAVVLFGLNALSGRTTAADGSAVGAWNSSDAEFLMRYSVNKGYTIHGWELGNEVSGKGIGTRIAADQYASDINNLQMIVQTIYAGFEVKPLVLAPGG FFDANWFTQFINKTPRSLQVVTHHIYNLGPGVDDHLIDKILNPSYLDGGSQPFRSLQGILKTSGTPAVAWVGEAGGAYNSGHNRVTNAFVFSFWYLDQLG MASSYDTKTYCRQTLIGGNYGLLNTGTFVPNPDYYSALLWHRLMGRNVLSTTFSGTNNIRAYAHCAKASKGITLLLINLDGNTTVEVHVSTENVTGNGTL VTQQQNQTKFSGMSKGSNIDVSTREEYHLTALNGDLHSQTVLLNGNILSVNSSGSVPPLEPIETSQSDPITVAPFSIVFAHIAN |
Full Sequence |
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Protein Sequence Length: 564 Download |
MATLNADRET NTRHCFYQMG SLFAVCVFCA CFYWLSATSK SAASQRTGGP RNIVEGTVFI 60 NGTAPIGTTD HDFICATLDW WPPDKCDYGT CSWGKASFLN LDLTNPILLN AIKAFSPLKI 120 RMGGTLQDKV TYERLGEPCP TFVKSSPEMF GFSQGCLPMS RWDELNNFFK QAGAVVLFGL 180 NALSGRTTAA DGSAVGAWNS SDAEFLMRYS VNKGYTIHGW ELGNEVSGKG IGTRIAADQY 240 ASDINNLQMI VQTIYAGFEV KPLVLAPGGF FDANWFTQFI NKTPRSLQVV THHIYNLGPG 300 VDDHLIDKIL NPSYLDGGSQ PFRSLQGILK TSGTPAVAWV GEAGGAYNSG HNRVTNAFVF 360 SFWYLDQLGM ASSYDTKTYC RQTLIGGNYG LLNTGTFVPN PDYYSALLWH RLMGRNVLST 420 TFSGTNNIRA YAHCAKASKG ITLLLINLDG NTTVEVHVST ENVTGNGTLV TQQQNQTKFS 480 GMSKGSNIDV STREEYHLTA LNGDLHSQTV LLNGNILSVN SSGSVPPLEP IETSQSDPIT 540 VAPFSIVFAH IANSTVPACE YVD* 600 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 0 | 54 | 369 | 319 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI25561.1 | 0 | 19 | 560 | 1 | 533 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002283254.1 | 0 | 19 | 559 | 1 | 536 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002283260.1 | 0 | 19 | 561 | 1 | 547 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002324878.1 | 0 | 56 | 559 | 1 | 504 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002515478.1 | 0 | 54 | 562 | 13 | 525 | heparanase, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.00004 | 120 | 459 | 75 | 409 | A Chain A, Crystal Structure Of Class V Chitinase (E115q Mutant) From Nicotiana Tobaccum In Complex With Nag4 |
PDB | 3vnz_A | 0.00004 | 120 | 459 | 75 | 409 | A Chain A, Crystal Structure Of Class V Chitinase (E115q Mutant) From Nicotiana Tobaccum In Complex With Nag4 |
PDB | 3vny_A | 0.00004 | 120 | 459 | 75 | 409 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |